NF-kappaB complex

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Name: NF-kappaB complex
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Namespace Version: 20190224
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/go-names.belns

Appears in Networks 5

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

RelB/p50 complexes regulate cytokine-induced YKL-40 expression v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

In-Edges 94

a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

We observed that anatabine dose dependently inhibited NFκB activation by TNFα in HEK293 NFκB luciferase reporter cells (Fig. 5) whereas nicotine was ineffective PubMed:21958873

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Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

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Experimental Factor Ontology (EFO): CHO cell

a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

In addition, an inhibition of p65 NFκB phosphorylation was observed following treatment with anatabine in 7W CHO overexpressing APP (Fig. 6A), in HEK293 (Fig. 6B) and in human neuronal like SH-SY5Y cells (Fig. 6C) showing that anatabine can prevent NFκB activation in various cell lines. PubMed:21958873

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Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

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Experimental Factor Ontology (EFO): CHO cell
Experimental Factor Ontology (EFO): SH-SY5Y

a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Since BACE-1 transcription is regulated by NFκB (Buggia-Prevot et al., 2008) and since we have shown that anatabine inhibits NFκB activation, we investigated the effect of anatabine on BACE-1 transcription using human neuronal like SH-SY5Y cells PubMed:21958873

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Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Since anatabine lowers NFκB activation in vitro, we explored the possibility that anatabine may affect the level of C-reactive protein (CRP) whose expression is NFκB dependent (Karlsen et al., 2010; Yang et al.,2010). PubMed:21958873

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Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

a(CHEBI:nicotine) causesNoChange act(complex(GO:"NF-kappaB complex")) View Subject | View Object

We observed that anatabine dose dependently inhibited NFκB activation by TNFα in HEK293 NFκB luciferase reporter cells (Fig. 5) whereas nicotine was ineffective PubMed:21958873

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Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

Annotations

Experimental Factor Ontology (EFO): CHO cell

p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

We observed that anatabine dose dependently inhibited NFκB activation by TNFα in HEK293 NFκB luciferase reporter cells (Fig. 5) whereas nicotine was ineffective PubMed:21958873

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Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

Annotations

Experimental Factor Ontology (EFO): CHO cell

a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

In addition, we verified that pharmacological inhibition of Syk with BAY61-3606 resulted in a blockade of NFkB activation and that genetic down-regulation of SYK using shRNA also prevented NFkB activation (data not shown) thus highlighting Syk as a key player of NFkB activation. PubMed:25331948

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

PMA is a known agonist of PKC, which leads to the activation of the PKC/RAS/RAF/MEK/MAPK pathway that ultimately induces NFkB activation (46–48) PubMed:25331948

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

a(CHEBI:Nilvadipine) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

The magnitude of the NFkB inhibition following (-)-nilvadipine treatment was also reduced in clones of HEK293 NFkB luciferase reporter cells in which Syk expression had been silenced (data not shown) further suggesting that Syk is required to mediate the inhibition of NFkB activity induced by (-)-nilvadipine. PubMed:25331948

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

act(p(HGNC:SYK)) regulates act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Tyrosine kinases, including Syk and Bruton’s tyrosine kinase (BTK), are activated following PMA treatment (49, 50), act upstream of RAS/RAF (51, 52), and mediate the activation of the NFkB pathway (53). PubMed:25331948

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

p(HGNC:SYK) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

p(HGNC:SYK) regulates act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Weobserved that (-)-nilvadipine inhibits NFkB activation in response to TNFα (Fig. 4A) or phorbol 12-myristate 13-acetate (PMA) (Fig. 4B) by using an NFkB-luciferase reporter cell line to monitor NFkB activation, thus suggesting a possible mechanism responsible for the inhibition of BACE-1 transcription following nilvadipine treatment PubMed:25331948

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

composite(a(CHEBI:Nilvadipine), p(HGNC:TNF)) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

For instance, the small GTPase Rho and its downstream effector Rho-associated coiled-coil containing protein kinase (ROCK) have been shown to contribute to TNFα induction of NFkB activation (45). PubMed:25331948

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

act(p(HGNC:BTK)) regulates act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

p(MGI:"interleukin 1 alpha") increases complex(GO:"NF-kappaB complex") View Subject | View Object

NF-κB and STAT3 are the major transcription factors activated by IL-1 and OSM, respectively PubMed:25681350

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RelB/p50 complexes regulate cytokine-induced YKL-40 expression v1.0.0

p(MGI:"oncostatin M") increases complex(GO:"NF-kappaB complex") View Subject | View Object

NF-κB and STAT3 are the major transcription factors activated by IL-1 and OSM, respectively PubMed:25681350

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RelB/p50 complexes regulate cytokine-induced YKL-40 expression v1.0.0

p(MGI:"tumor necrosis factor") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Since TNF also efficiently activates NF-κB, we tested whether, similarly to IL-1, TNF regulates YKL-40 expression by a RelB-dependent mechanism. PubMed:25681350

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RelB/p50 complexes regulate cytokine-induced YKL-40 expression v1.0.0

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Recent evidence has cogently shown that Amyloid-β induces apoptosis in rat primary neurons and human post-mitotic neuronal cells by reducing Bcl-XL expression level and evoking the release of cytochrome c from the mitochondria in a NF-κB – dependent manner PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

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MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Furthermore, fibrillar Amyloid-β has been shown to activate NF-κB via the assembly pf the C5b-MAC complex PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases complex(GO:"NF-kappaB complex") View Subject | View Object

Furthermore, Amyloid-β actuates NF-κB – dependent pro-inflammatory pathways in microglia culminating in TNFα expression and subsequently TNFα effectuated neurotoxicity PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

In primary neuronal cultures, Amyloid-β has been shown to elicit oxidative stress and evoke NF-κB activation PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Furthermore, Amyloid-β –induced NF-κB also results in the up-regulation of the antioxidant mitochondrial membrane enzyme – MnSOD (superoxide dismutase 2) [328] which is well known to combat oxidative stress and apoptosis PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"nitric oxide") decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Furthermore, nitric oxide (NO), a well characterized repressor of NF-κB activation and signaling [174, 175], causes a mitigation in neurogenesis PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Physiological, pathophysiological, and biochemical stimuli known to induce proliferation of NPC via NF-κB activation include cerebral infarction [165], traumatic brain injury [166], reactive oxygen species [167], hypoxia [168-172], sAPPα [147], and sphingosine-1-phosphate [173] PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

a(CHEBI:"sphingosine 1-phosphate") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Additionally, NF-κB activity is also actuated by glutamate- mediated excitatory neurotransmission in the hippocampus, cerebral cortex, and the cerebellar granule cells PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Cerebral Cortex
MeSH: Hippocampus
MeSH: Alzheimer Disease

act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Consequently, NF-κB is constitutively activated in the excitatory neurons of the cerebral cortex (layers 2, 4, and 5), hippocampus (granule and pyramidal neurons of CA1 and CA3), and cerebellar granule cells and this constitutive activity is indispensable for neuronal survival in response to glutamate-induced excitotoxicity PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

The molecular mechanism underlying constitutive activation of NF-κB by glutamate-induced excitatory synaptic neurotransmission has been ascribed to NMDA receptor mediated Ca2+ influx and subsequent activation of CaMKII PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(MESH:"Cerebral Cortex") negativeCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Moreover, NF-κB mediates the NSC migration in response to physiological and pathophysiological stimuli such as cerebral cortex injury [181], seizure [182], and ischemic stroke PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

a(MESH:Calcineurin) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Emerging evidence has implicated Amyloid-β in augmenting cytosolic Ca2+ levels and causing NF- κB activation via calcineurin in astrocytes PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

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MeSH: Cytosol
MeSH: Alzheimer Disease

bp(GO:"Fas signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Amyloid-β has also been demonstrated to induce apoptosis via the JNK1/c-Jun/Fas ligand signaling cascade [110], which results in NF-κB activation PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"JNK cascade") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Amyloid-β has also been demonstrated to induce apoptosis via the JNK1/c-Jun/Fas ligand signaling cascade [110], which results in NF-κB activation PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"calcium ion homeostasis") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Amyloid-β induced apoptosis has also been ascribed to dyshomeostasis of intracellular Ca2+ and oxidative stress [106-108], two critical biochemical derangements known to activate NF-κB PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"calcium ion import") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

The three well characterized sensors of intracellular calcium – calmodulin/CamKII pathway, PI3K/ Akt pathway, and protein kinase C (PKC) pathway – are known to induce NF-κB activation and couple upstream signal transduction pathways that induce calcium dyshomeostasis to NF-κB activation PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Moreover, there is preponderance of data implicating Amyloid-β in the modulation of PKC signaling pathway [335-338] and the PI3K/Akt/mTOR signaling pathway [339-341], which are known to activate NF-κB signaling pathway PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

NF-κB acts as a sensor of oxidative stress and it is well established that oxidative stress results in the activation of NF-κB PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

In primary neuronal cultures, Amyloid-β has been shown to elicit oxidative stress and evoke NF-κB activation PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"IkappaB kinase complex")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

In addition to CamKII, other kinases activated in response to a rise in cytosolic Ca2+ such as protein kinase C (PKC), phosphatidylinositol-3-kinase (PI3K), and Akt, also activate NF-κB signaling pathway by increasing the phosphorylation and activation of IKK PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

There is evidence that Amyloid-β causes the activation of Ca2+/calmodulin/CamKII pathway [332-334], thereby potentially leading to NF-κB activation. PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(a(GO:"membrane attack complex"), p(HGNC:C5)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Furthermore, fibrillar Amyloid-β has been shown to activate NF-κB via the assembly pf the C5b-MAC complex PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) hasComponent complex(GO:"NF-kappaB complex") View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) hasComponent complex(GO:"NF-kappaB complex") View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

act(p(FPLX:AKT)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HBP:"sAPP-alpha") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Both, brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) promote neurite outgrowth, in a NF- κB - dependent manner, in primary cultures of nodose ganglion sensory neurons from developing mice PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:BDNF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

NF-κB positively regulates the transcription of interleukin 6 (IL6) family of cytokines such as IL6, leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) [184], which in-turn induce the differentiation of NSC into astrocytes by activating transcription factors STAT3, AP-1, and NF-κB itself PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:EGF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

The trophic factors that evoke proliferation of NPC by inducing activation of NF-κB include epidermal growth factor (EGF) [155-161], basic fibroblast growth factor (bFGF) [155-161], vascular endothelial growth factor (VEGF) [162], tumor necrosis factor α (TNFα) [163], and erythropoietin (EPO) PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HGNC:FGF2) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HGNC:IL6) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:LIF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

The mechanism underlying the effect of BDNF and CNTF on NF-κB activation has been attributed to the activation of Src and Lck non-receptor tyrosine kinases which phosphorylate IκBα on Tyr42 resulting in subsequent NF-κB activation PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:SIRT1) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Furthermore, negative regulators of NF-κB such as the NAD+- dependent histone deacetylase – SIRT1, abolish the deleterious neurotoxic effects of Amyloid-β PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HGNC:VEGFA) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(HP:"Ischemic stroke") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Moreover, NF-κB mediates the NSC migration in response to physiological and pathophysiological stimuli such as cerebral cortex injury [181], seizure [182], and ischemic stroke PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(HP:Seizures) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Moreover, NF-κB mediates the NSC migration in response to physiological and pathophysiological stimuli such as cerebral cortex injury [181], seizure [182], and ischemic stroke PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(MESH:"Brain Injuries, Traumatic") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(MESH:"Cerebral Infarction") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(MESH:Hypoxia) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

In neuronal cells Aβ1-42 peptide has been shown to regulate APP and BACE1 proteins in NF-κB dependent manner PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neurons
MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Excessive accumulation of Aβ1-42 stimulates microglial cells by signaling via receptor associated advanced glycation end products (RAGE) and peroxisome proliferator-activated receptor-γ (PPAR-γ), phosphorylates IKK proteins, and enhances NF-κB mediated transactivation of inflammatory cytokines and neurotoxic molecules such as glutamate and reactive oxygen species (ROS)/induced nitric oxide synthase (iNOS) [12] (Fig 2B) PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Under physiological conditions activation of NF-κB by endogenous Aβ reduces βAPP, BACE1 and the γ-secretase activity, thereby lowering Aβ processing and facilitating Aβ homeostasis PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

However in AD, exposure to high Aβ concentrations upregulates NF-κB activation increasing βAPP and Aβ processing, precipitating a feed-back loop that favor exacerbated Aβ production PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Mechanistically, the Aβ induced neuronal apoptosis has been attributed to the increase in the ratio of proapoptotic gene (BAX) transcription to that of the anti-apoptotic gene Bcl-Xl, and/or to the reduction in constitutively activated NF-κB with consequent increase in the cytoplasmic IκB proteins PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

This is supported by the observation that in mixed neuronal-glial cell cultures, Aβ induces increasing degree of neurotoxicity in an NF-κB dependent manner in the presence of higher proportion of glial cells PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neuroglia
MeSH: Neurons
MeSH: Alzheimer Disease

a(GO:"neurofibrillary tangle") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

A consequence of intracellular and parenchymal accumulation of NPs and NFTs is activation of NF-κB in the neural and glial cells with subsequent protective or detrimental effects PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neuroglia
MeSH: Neurons
MeSH: Alzheimer Disease

a(MESH:"I-kappa B Proteins") decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Unlike neurons, NF-κB is present in the cytoplasm as an inactive complex with the IκB proteins in glial cells under physiological conditions PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Cytoplasm
MeSH: Neuroglia

a(MESH:"amyloid beta-protein (25-35)") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

In primary neuronal cells, exposure to Aβ25-35 peptide increase NF-κB mediated transactivation of manganese superoxide dismutase (Mn-SOD), suppress peroxinitrite production and inhibit membrane depolarization, thereby preventing apoptosis induced by oxidative stress PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neurons
MeSH: Alzheimer Disease

bp(GO:"calmodulin dependent kinase signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Several kinase pathways including the calcium-calmodium dependent kinase-II (CaMK), the protein kinases-C (PKC) and the ras/phosphatidylinositol 3-kinase (PI3K) pathways have been implicated in activating neuronal NF-κB signaling PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neurons

bp(GO:"membrane depolarization") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

A number of physiological stimuli including membrane depolarization or glutamergic signal transduction lead to rapid activation of the inducible NF-κB localized in the synapses, cytoplasm and dendrites of the neurons PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Cytoplasm
MeSH: Dendrites
MeSH: Neurons
MeSH: Synapses

bp(GO:"phosphatidylinositol 3-kinase signaling") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neurons

bp(GO:"synaptic transmission, glutamatergic") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Cytoplasm
MeSH: Dendrites
MeSH: Neurons
MeSH: Synapses

bp(HBP:"APP processing") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) hasComponent complex(GO:"NF-kappaB complex") View Subject | View Object

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neurons

p(HBP:"sAPP-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:APOE)) association complex(GO:"NF-kappaB complex") View Subject | View Object

Aβ has been shown to upregulate APOE in astroglial cells. This upregulation was inhibited by decoy-κB nucleotides supporting a critical role for NFκB in APOE function PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Astrocytes
MeSH: Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

These observations substantiate a direct role of neuronal NF–κB activation in the pathogenesis of AD PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neurons
MeSH: Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") View Subject | View Object

Increased presence of activated glial cells presenting elevated NF-κB and HLA-DR expression are commonly observed around the Aβ plaques in postmortem AD tissue PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") View Subject | View Object

Increased presence of NF-κB mediated IL-1β, IL-6, and TNF-α cytokines have been reported in the affected tissues, serum and CSF of AD patients PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

path(MESH:"Plaque, Amyloid") positiveCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

A consequence of intracellular and parenchymal accumulation of NPs and NFTs is activation of NF-κB in the neural and glial cells with subsequent protective or detrimental effects PubMed:25652642

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neuroglia
MeSH: Neurons
MeSH: Alzheimer Disease

path(MESH:"Plaque, Amyloid") association complex(GO:"NF-kappaB complex") View Subject | View Object

Increased presence of activated glial cells presenting elevated NF-κB and HLA-DR expression are commonly observed around the Aβ plaques in postmortem AD tissue PubMed:25652642

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

Out-Edges 135

complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) View Subject | View Object

Appears in Networks:

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

complex(GO:"NF-kappaB complex") regulates p(HGNC:CRP) View Subject | View Object

Appears in Networks:

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0

complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) View Subject | View Object

As (-)-nilvadipine and racemic nilvadipine inhibit BACE-1 transcription, we evaluated whether (-)-nilvadipine was impacting NFkB activation because NFkB has been shown to play an important role in the regulation of BACE-1 transcription and expression (36, 37, 43, 44) PubMed:25331948

Appears in Networks:

The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") View Subject | View Object

The indispensable role of NF-κB in synaptic transmission is corroborated by the fact that the mice that are deficient in neuronal p65, exhibit severe deficits in hippocampal basal synaptic transmission and long term potentiation (LTP) PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") View Subject | View Object

Given the indispensable role of NF-κB proteins in synaptic transmission and synaptic plasticity, it is not surprising that NF-κB is plays an indispensable role in cognition and behavior as well PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") View Subject | View Object

Preponderance of evidence has implicated NF-κB as a survival factor in neurons [24, 114, 115] primarily because of the ability of NF-κB to suppress apoptosis in response to excitotoxic and apoptotic stimuli PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") View Subject | View Object

Inhibition of NF-κB activity using a κB decoy DNA that results in the sequestration of NF-κB, increases the susceptibility of hippocampal neurons to noxious and apoptotic stimuli PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") View Subject | View Object

NF-κB activation also protects hippocampal neurons from oxidative stress-induced apoptosis by inducing manganese superoxide dismutase (MnSOD) expression and mitigating peroxynitrite-induced protein nitration PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates bp(GO:cognition) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates bp(GO:behavior) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases path(MESH:"Spatial Memory") View Subject | View Object

NF-κB is also indispensable for longterm spatial memory as assessed by radial arm maze [25] and Morris water maze paradigms in mice PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases bp(GO:memory) View Subject | View Object

The molecular mechanisms underlying the aforementioned involvement of NF-κB proteins in learning and memory have not been completely comprehended, although recent evidence has implicated NF-κB – induced transcriptional activation of Protein Kinase A (PKA) catalytic subunit that culminates in activation of CREB (cyclic AMP-response element binding protein) signaling [77] which is regarded as the molecular switch that converts short-term memory to long-term memory PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases bp(GO:learning) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases act(p(HGNC:PRKACA)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) View Subject | View Object

This is counter-intuitive as it is established that NF-κB positively regulates the expression of Bcl-XL and other members of the Bcl2 family PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) View Subject | View Object

The anti-apoptotic effects of NF-κB have been ascribed to its ability to trans-activate the expression of a multitude of anti-apoptotic genes such as Bcl-2, Bcl-XL, and Bfl-1/A1 in the neurons of the amygdala, olfactory bulb, and the CA1/CA3 region of the hippocampus PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases sec(a(PUBCHEM:16057918)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Mitochondria
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2A1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases act(a(MESH:"Amyloid beta-Peptides")) View Subject | View Object

NF-κB activity abrogates Amyloid-β peptide-induced toxicity in dissociated hippocampal cultures from C57Bl/6 mice PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases a(GO:axon) View Subject | View Object

Multiple studies have implicated NF-κB in the regulation of post-natal axonal growth or neurite outgrowth. PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases p(MESH:Proteins, pmod(HBP:nitration)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) View Subject | View Object

NF-κB also plays a vital role in axon guidance subsequent to neurogenesis and axon growth in response to neurotrophins, resulting in the integration of the nascent neurons PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates a(MESH:"Neural Stem Cells") View Subject | View Object

Moreover, NF-κB mediates the NSC migration in response to physiological and pathophysiological stimuli such as cerebral cortex injury [181], seizure [182], and ischemic stroke PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) negativeCorrelation a(MESH:"Cerebral Cortex") View Subject | View Object

Moreover, NF-κB mediates the NSC migration in response to physiological and pathophysiological stimuli such as cerebral cortex injury [181], seizure [182], and ischemic stroke PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"stem cell division") View Subject | View Object

NF-κB also plays a pivotal role in the differentiation of neural stem cells PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Neurons
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

IL6 is another NF-κB – induced [256-260] pro-inflammatory cytokine up-regulated and integrally involved in the etio-pathogenesis of Alzheimer’s disease PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

Furthermore, NF-κB - induced IL6 has been demonstrated to evoke hyperphosphorylation of tau at Ser202 and Thr205 via the activation of the cdk5/p35 complex PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

Amyloid-β also induces microglial activation that results in NF-κB – induced expression of pro-inflammatory cytokines such as TNFα, IL1β, IL6, and IL8 from the microglia resulting in neuronal death PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"astrocyte development") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:LIF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:CNTF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"dendritic spine organization") View Subject | View Object

NF-κB is also indispensable in the neuronal differentiation of neuroblastoma cells [186] as its transcriptional activity directly orchestrates dendritic spine formation and neurite outgrowth PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Multiple studies have implicated NF-κB in the regulation of post-natal axonal growth or neurite outgrowth. PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

This paradoxical incongruity in the effects of NF-κB emanate from the prevailing phosphorylation status of the p65 subunit (Ser536) and coinciding physiological and biochemical stimuli, with the phosphorylation status of p65 being inversely related to the NF-κB – induced neurite outgrowth PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"axon guidance") View Subject | View Object

NF-κB also plays a vital role in axon guidance subsequent to neurogenesis and axon growth in response to neurotrophins, resulting in the integration of the nascent neurons PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:ITGB1) View Subject | View Object

NF-κB positively regulates the expression of extracellular matrix protein involved in cell adhesion, β1-integrin [199], a well characterized pivotal player in axon growth initiation and guidance PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:NCAM1) View Subject | View Object

Furthermore, NF-κB directly regulates the expression of a plethora of cell adhesion molecules such as neural cell adhesion molecule (NCAM) [202], slit and Trk-like family member 1 (SLITRK1) [203], glial cell-derived neurotrophic factor receptor α1 (GFRα1) [204], and T-lymphoma and metastasis 1 (TLAM1) [203], key players in directing axon growth. PubMed:28745240

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Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:SLITRK1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:GFRA1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:TIAM1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Dendritic Cells") View Subject | View Object

NF-κB is integrally involved in the orchestration of growth of dendritic arbors and critically regulates dendritic morphology because of its indispensable role in dendritic growth and branching PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases a(GO:"dendritic branch") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES1) View Subject | View Object

NF-κB activation directly induces the transcription of Hes1 and Hes5 [206, 207], two key transcription factors involved in the regulation of expression of proteins involved in dendritic growth, morphology, and branching PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES5) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:MAP1B) View Subject | View Object

NF-κB activates the expression of the two microtubule-associated proteins, microtubule-associated protein 1B (MAP1B) and microtubule-associated protein 2 (MAP2) [209], two major proteins known to play a pivotal role in the growth, elongation, and arborization of dendrites PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:MAP2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:C3) View Subject | View Object

NF-κB directly regulates the transcription of a multitude of proteins of the complement pathway that are involved in antigen presenting such as C3 (complement component 3) [241], Bf (complement factor B) [242], and CR2 (complement receptor 2) [243] as well as acute phase proteins such as C4 (complement factor 4) [244] and C4BPA (complement factor 4 binding protein) PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:CFB) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:CR2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:C4A) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:C4BPA) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:IL1B) View Subject | View Object

It is well established that NF-κB is one of the most prominent transcription factors that regulates IL1β production PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases act(p(HGNC:IL1A)) View Subject | View Object

Moreover, NF-κB – induced IL1 genesis has been shown to precipitate tau phosphorylation at Ser202 and Thr205 (AT8 epitopes) via the activation of the p38- MAPK pathway PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Moreover, NF-κB – induced IL1 genesis has been shown to precipitate tau phosphorylation at Ser202 and Thr205 (AT8 epitopes) via the activation of the p38- MAPK pathway PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Furthermore, NF-κB - induced IL6 has been demonstrated to evoke hyperphosphorylation of tau at Ser202 and Thr205 via the activation of the cdk5/p35 complex PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) View Subject | View Object

Furthermore, NF-κB - induced IL6 has been demonstrated to evoke hyperphosphorylation of tau at Ser202 and Thr205 via the activation of the cdk5/p35 complex PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:TNF) View Subject | View Object

Another known target of NF-κB, TNFα [266, 267] is also up-regulated in the cortex [268], cerebrospinal fluid, and the serum of Alzheimer’s disease patients PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) View Subject | View Object

Furthermore, Amyloid-β actuates NF-κB – dependent pro-inflammatory pathways in microglia culminating in TNFα expression and subsequently TNFα effectuated neurotoxicity PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases sec(a(CHEBI:"amyloid-beta")) View Subject | View Object

Multiple studies have cogently shown that the inhibition of NF-κB activity results in the mitigation of secreted Amyloid-β by cultured cells in vitro PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases a(CHEBI:"amyloid-beta") View Subject | View Object

NF-κB is also widely implicated in the engenderment of Amyloid-β in vivo in a multitude of mouse models PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") View Subject | View Object

A multitude of studies have demonstrated that NF-κB directly regulates the transcription and expression of BACE1, thereby eliciting profound effects on AβPP processing and engenderment of Amyloid-β PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") View Subject | View Object

Indeed, Checler and colleagues have shown in a recent study that, NF-κB mediates the Amyloid-β – induced increase in expression of AβPP in HEK293 cells PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

Experimental Factor Ontology (EFO): HEK293
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) View Subject | View Object

NF-κB induced up-regulation in BACE1 expression is contingent on the nature of the NF-κB heterodimer PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates bp(HBP:"APP processing") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HBP:C99) View Subject | View Object

Recent studies have unveiled a novel role of NF-κB in the regulation of the γ-secretase activity mediated processing of the C99 (CTFβ) fragment PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates act(complex(GO:"gamma-secretase complex")) View Subject | View Object

Recent studies have unveiled a novel role of NF-κB in the regulation of the γ-secretase activity mediated processing of the C99 (CTFβ) fragment PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases act(complex(GO:"gamma-secretase complex")) View Subject | View Object

In addition to augmenting γ-secretase activity, NF-κB also regulates the expression of the PS1 subunit of the γ-secretase complex PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:PSEN1) View Subject | View Object

In addition to augmenting γ-secretase activity, NF-κB also regulates the expression of the PS1 subunit of the γ-secretase complex PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) View Subject | View Object

Furthermore, two κB-binding sites have been identified in the proximal promoter region of AβPP, suggesting the potential regulation of AβPP expression by NF-κB PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) View Subject | View Object

Indeed, Checler and colleagues have shown in a recent study that, NF-κB mediates the Amyloid-β – induced increase in expression of AβPP in HEK293 cells PubMed:28745240

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

Experimental Factor Ontology (EFO): HEK293
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"calcium ion homeostasis") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:CXCL8) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Synaptic Transmission") View Subject | View Object

In conditional neuronal NF-κB-deficient mice, loss of NF-κB signaling impaired synaptic transmission, spatial memory formation, and plasticity PubMed:25652642

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

act(complex(GO:"NF-kappaB complex")) increases path(MESH:"Spatial Memory") View Subject | View Object

In conditional neuronal NF-κB-deficient mice, loss of NF-κB signaling impaired synaptic transmission, spatial memory formation, and plasticity PubMed:25652642

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

In conditional neuronal NF-κB-deficient mice, loss of NF-κB signaling impaired synaptic transmission, spatial memory formation, and plasticity PubMed:25652642

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") View Subject | View Object

Complete abrogation of the DNA binding ability of NFκB factors induces apoptosis of the neuronal cells PubMed:25652642

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Neurons

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neurons
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") View Subject | View Object

Cell death is preceded by reduction in the NF-κB regulated transcription of anti-apoptotic genes suggesting that a minimal threshold of NF-κB activity is needed for neuronal survival PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"inflammatory response") View Subject | View Object

Various endogenous and exogenous stimuli activate NF-κB enhancing transactivation of inflammatory molecules and production of free radicals in glial cells PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neuroglia

act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Free Radicals") View Subject | View Object

Various endogenous and exogenous stimuli activate NF-κB enhancing transactivation of inflammatory molecules and production of free radicals in glial cells PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neuroglia

act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

A consequence of intracellular and parenchymal accumulation of NPs and NFTs is activation of NF-κB in the neural and glial cells with subsequent protective or detrimental effects PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neuroglia
MeSH: Neurons
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Plaque, Amyloid") View Subject | View Object

A consequence of intracellular and parenchymal accumulation of NPs and NFTs is activation of NF-κB in the neural and glial cells with subsequent protective or detrimental effects PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neuroglia
MeSH: Neurons
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") association path(MESH:"Plaque, Amyloid") View Subject | View Object

Increased presence of activated glial cells presenting elevated NF-κB and HLA-DR expression are commonly observed around the Aβ plaques in postmortem AD tissue PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:APP) View Subject | View Object

In neuronal cells Aβ1-42 peptide has been shown to regulate APP and BACE1 proteins in NF-κB dependent manner PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neurons
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:BACE1) View Subject | View Object

In neuronal cells Aβ1-42 peptide has been shown to regulate APP and BACE1 proteins in NF-κB dependent manner PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neurons
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases p(HGNC:BACE1) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

act(complex(GO:"NF-kappaB complex")) decreases p(HBP:"sAPP-beta") View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(HBP:"sAPP-beta") View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(HBP:"APP processing") View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

act(complex(GO:"NF-kappaB complex")) positiveCorrelation bp(HBP:"APP processing") View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) regulates a(CHEBI:"amyloid-beta") View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(CHEBI:"amyloid-beta") View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") association act(p(HGNC:APOE)) View Subject | View Object

Aβ has been shown to upregulate APOE in astroglial cells. This upregulation was inhibited by decoy-κB nucleotides supporting a critical role for NFκB in APOE function PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Astrocytes
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases bp(MESH:Neuroprotection) View Subject | View Object

Decoy κB nucleotides mediate cell death by blocking neurotrophins and anti-apoptotic factors supporting an essential role for NF-κB in the neuroprotective process PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates bp(MESH:Neuroprotection) View Subject | View Object

These NF-κB mediated neuroprotective effects have been largely observed in early stages of neuronal regeneration in AD PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:SOD2)) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neurons
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases a(CHEBI:peroxynitrite) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neurons
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"membrane depolarization") View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neurons
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases a(MESH:"Cholinergic Neurons") View Subject | View Object

Comparison of the cellular distribution of NF-κB in the nucleus basalis of Meynert of AD and control patients showed that the proportion of large cholinergic neurons with elevated nuclear p65 was significantly increased in AD, suggesting an association between NF–κB functions and the process of cholinergic degeneration PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

These observations substantiate a direct role of neuronal NF–κB activation in the pathogenesis of AD PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neurons
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Increased presence of activated glial cells presenting elevated NF-κB and HLA-DR expression are commonly observed around the Aβ plaques in postmortem AD tissue PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Increased presence of NF-κB mediated IL-1β, IL-6, and TNF-α cytokines have been reported in the affected tissues, serum and CSF of AD patients PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Microglia)) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines)) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"glutamate(1-)")) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) View Subject | View Object

Furthermore NF-κB specific inhibitor prevents iNOS and ROS upregulation in Aβ stimulated cultures of astrocytes or mixed cortical cells PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) View Subject | View Object

Furthermore NF-κB specific inhibitor prevents iNOS and ROS upregulation in Aβ stimulated cultures of astrocytes or mixed cortical cells PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) View Subject | View Object

Increased presence of NF-κB mediated IL-1β, IL-6, and TNF-α cytokines have been reported in the affected tissues, serum and CSF of AD patients PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

Increased presence of NF-κB mediated IL-1β, IL-6, and TNF-α cytokines have been reported in the affected tissues, serum and CSF of AD patients PubMed:25652642

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) View Subject | View Object

Increased presence of NF-κB mediated IL-1β, IL-6, and TNF-α cytokines have been reported in the affected tissues, serum and CSF of AD patients PubMed:25652642

Appears in Networks:

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases path(HBP:neurotoxicity) View Subject | View Object

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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

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MeSH: Neuroglia
MeSH: Neurons
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates m(HGNC:"MIR9-1") View Subject | View Object

Upregulation of several NF-κB regulated miRNAs such as miRNA-9, miRNA-34a, miRNA-125b, miRNA-146a, miRNA-155 and miRNA-339 5p have been observed in stressed primary human neuronalglial cells and in postmortem AD brain tissues PubMed:25652642