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a(MESH:Calcineurin)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Calcineurin
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/mesh-names.belns

Appears in Networks 2

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

In-Edges 3

act(a(CHEBI:nicotine)) association a(MESH:Calcineurin) View Subject | View Object

Stevens et al. (2003) showed that calcineurin is involved in nicotine neuroprotection. Abeta, through alpha7 nAChRs, increases Ca2+, which phosphorylates NMDARs via calcineurin and protein tyrosine phosphatase, nonreceptor type 5 (striatum-enriched) (Snyder et al., 2005). PubMed:19293145

Appears in Networks:

bp(MESH:Neuroprotection) association a(MESH:Calcineurin) View Subject | View Object

Stevens et al. (2003) showed that calcineurin is involved in nicotine neuroprotection. Abeta, through alpha7 nAChRs, increases Ca2+, which phosphorylates NMDARs via calcineurin and protein tyrosine phosphatase, nonreceptor type 5 (striatum-enriched) (Snyder et al., 2005). PubMed:19293145

Appears in Networks:

composite(a(CHEBI:"calcium(2+)"), a(MESH:Calcineurin), p(HGNC:PTPN5)) hasComponent a(MESH:Calcineurin) View Subject | View Object

Appears in Networks:

Out-Edges 3

a(MESH:Calcineurin) association act(a(CHEBI:nicotine)) View Subject | View Object

Stevens et al. (2003) showed that calcineurin is involved in nicotine neuroprotection. Abeta, through alpha7 nAChRs, increases Ca2+, which phosphorylates NMDARs via calcineurin and protein tyrosine phosphatase, nonreceptor type 5 (striatum-enriched) (Snyder et al., 2005). PubMed:19293145

Appears in Networks:

a(MESH:Calcineurin) association bp(MESH:Neuroprotection) View Subject | View Object

Stevens et al. (2003) showed that calcineurin is involved in nicotine neuroprotection. Abeta, through alpha7 nAChRs, increases Ca2+, which phosphorylates NMDARs via calcineurin and protein tyrosine phosphatase, nonreceptor type 5 (striatum-enriched) (Snyder et al., 2005). PubMed:19293145

Appears in Networks:

a(MESH:Calcineurin) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Emerging evidence has implicated Amyloid-β in augmenting cytosolic Ca2+ levels and causing NF- κB activation via calcineurin in astrocytes PubMed:28745240

Appears in Networks:
Annotations
MeSH
Cytosol
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.