1. Catalog
  2. Networks
  3. RelB/p50 complexes regulate cytokine-induced YKL-40 expression v1.0.0

RelB/p50 complexes regulate cytokine-induced YKL-40 expression 1.0.0

Compilation Biogrammar
Explore Query

Provenance

Upload
charles.hoyt@scai.fraunhofer.de at 2019-05-15 22:26:58.320704
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
36
Number Edges
95
Number Components
2
Network Density
0.0753968253968254
Average Degree
2.63888888888889
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0 11%
Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0 10%
Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-b peptide and s levels: target engagement, tolerability and pharmacokinetics in humans v0.1.0 9%
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0 8%
Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0 8%
Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0 6%
Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0 5%
Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD v1.0.0 5%
Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0 3%
albuquerque2009 v1.0.0 3%

Sample Edges

a(PUBCHEM:14235) increases r(MGI:"chitinase-like 1") View Subject | View Object

Indeed, YKL-40 mRNA expression was robustly activated in tissues surrounding the site of turpentine injection and its induction was accompanied by a very strong induction of both IL-1 and IL-6 mRNAs (Fig. 1A) PubMed:25681350

a(PUBCHEM:14235) increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") View Subject | View Object

RelB mRNA expression was also strongly activated in vivo by turpentine in an IL-1-dependent model of irritant-induced sterile inflammation (Fig. 4E). PubMed:25681350

complex(a(GO:"NF-kappaB p50/p65 complex"), p(MGI:"chitinase-like 1")) hasComponent a(GO:"NF-kappaB p50/p65 complex") View Subject | View Object

complex(a(GO:"NF-kappaB p50/p65 complex"), p(MGI:"chitinase-like 1")) hasComponent p(MGI:"chitinase-like 1") View Subject | View Object

p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") View Subject | View Object

Since p65 subunit of NF-κB and STAT3 were previously implicated in cytokine-induced expression of YKL-40 (8, 34), we knocked down their expression in human astrocytes PubMed:25681350

Sample Nodes

p(HGNC:CHI3L1)

In-Edges: 4 | Out-Edges: 0 | Explore Neighborhood | Download JSON

p(HGNC:STAT3)

In-Edges: 13 | Out-Edges: 6 | Explore Neighborhood | Download JSON

r(HGNC:CHI3L1)

In-Edges: 3 | Out-Edges: 1 | Explore Neighborhood | Download JSON

p(HGNC:RELA)

In-Edges: 23 | Out-Edges: 16 | Explore Neighborhood | Download JSON

p(HGNC:IL1A)

In-Edges: 3 | Out-Edges: 6 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.