Upload at 2018-04-03 15:16:29
Causal Biological Networks Database
The Hedgehog network depicts causal mechanisms that are involved in Hedgehog signaling, which regulates cell proliferation and branching morphogenesis in the developing mammalian lung. These processes may contribute to heightened proliferative activity following exposure to environmental insults.
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 30%
Selventa Protein Families Definitions v20150611 30%
Hedgehog-2.0-Hs v2.0 30%
Hedgehog-2.0-Mm v2.0 30%
Growth Factor-2.0-Rn v2.0 27%
Cell Cycle-2.0-Rn v2.0 24%
PGE2-2.0-Rn v2.0 24%
PGE2-2.0-Hs v2.0 22%
PGE2-2.0-Mm v2.0 22%
Fibrosis-2.0-Rn v2.0 22%

Sample Edges

act(p(SFAM:"AKT Family"), ma(kin)) decreases act(p(SFAM:"GSK3 Family"), ma(kin))

AKT activation resulted in the phosphorylation-dependent inactivation of glycogen synthase kinase (GSK-3) (serine 21/9). PubMed:11254732

act(p(SFAM:"AKT Family"), ma(kin)) decreases act(p(SFAM:"GSK3 Family"), ma(kin))

RTK signaling potentiates GLI activity through PI3K-AKT-mediated GSK3 inactivation or RAS-STIL1-mediated SUFU inactivation, while GPCR signaling to Gs represses GLI activity through adenylate cyclase-mediated PKA activation PubMed:19860666

a(SCHEM:"cyclic AMP") directlyIncreases act(p(SFAM:"PRKA Family"), ma(kin))

Because Rap1b is one of the proteins that become phosphorylated by PKA upon elevation of intracellular cAMP levels, we evaluated the effect of the absence of Rap1b in platelets on cAMP-induced inhibition of AYPGKF peptide-induced platelet aggregation (Figure ?(Figure4C).4C). PubMed:15696195

a(SCHEM:"cyclic AMP") directlyIncreases act(p(SFAM:"PRKA Family"), ma(kin))

Insulin also profoundly inhibits lipolysis in adipocytes, primarily through inhibition of the enzyme hormone sensitive lipase71. This enzyme is acutely regulated by control of its phosphorylation state, which is activated by PKA-dependent phosphorylation, and inhibited as a result of a combination of kinase inhibition and phosphatase activation. Insulin inhibits the activity of the lipase primarily through reductions in cAMP levels, owing to the activation of a cAMP-specific phosphodiesterase in fat cells72. PubMed:11742412

a(SCHEM:"cyclic AMP") directlyIncreases act(p(SFAM:"PRKA Family"), ma(kin))

Cyclic AMP activates PKA, therefore we expect to see an increased difference between active and inactive PKA when cAMP levels are physiologically high. PubMed:19607691

Sample Nodes


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