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Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-05-15 22:27:06.448984
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2019 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
71
Number Edges
147
Number Components
1
Network Density
0.0295774647887324
Average Degree
2.07042253521127
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0 44%
Anatabine lowers Alzheimer's Aβ production in vitro and in vivo v1.0.0 35%
Identification of a novel aspartic protease (Asp 2) as beta-secretase v1.0.0 30%
Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0 30%
Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0 25%
Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0 24%
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0 24%
Inflammasome Involvement in Alzheimer’s Disease v1.0.0 24%
The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice v1.0.0 23%
Tau Modifications v1.9.5 23%

Sample Edges

complex(p(HGNC:NFKB1), p(HGNC:RELA)) hasComponent p(HGNC:NFKB1) View Subject | View Object

complex(p(HGNC:NFKB1), p(HGNC:RELA)) hasComponent p(HGNC:RELA) View Subject | View Object

a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:APP) View Subject | View Object

In neuronal cells Aβ1-42 peptide has been shown to regulate APP and BACE1 proteins in NF-κB dependent manner PubMed:25652642

Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:BACE1) View Subject | View Object

In neuronal cells Aβ1-42 peptide has been shown to regulate APP and BACE1 proteins in NF-κB dependent manner PubMed:25652642

Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

In neuronal cells Aβ1-42 peptide has been shown to regulate APP and BACE1 proteins in NF-κB dependent manner PubMed:25652642

Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

Sample Nodes

a(CHEBI:"amyloid-beta")

In-Edges: 423 | Out-Edges: 245 | Children: 5 | Explore Neighborhood | Download JSON

a(MESH:Microglia)

In-Edges: 19 | Out-Edges: 25 | Explore Neighborhood | Download JSON

bp(GO:"inflammatory response")

In-Edges: 55 | Out-Edges: 24 | Explore Neighborhood | Download JSON

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:APP)

In-Edges: 106 | Out-Edges: 69 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.