Provenance

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charles.hoyt@scai.fraunhofer.de at 2018-04-03 15:16:29
Authors
Causal Biological Networks Database
Contact
CausalBiologicalNetworks.RD@pmi.com
Description
The Hedgehog network depicts causal mechanisms that are involved in Hedgehog signaling, which regulates cell proliferation and branching morphogenesis in the developing mammalian lung. These processes may contribute to heightened proliferative activity following exposure to environmental insults.
License
Please cite: - www.causalbionet.com - https://bionet.sbvimprover.com as well as any relevant publications. The sbv IMPROVER project, the website and the Symposia are part of a collaborative project designed to enable scientists to learn about and contribute to the development of a new crowd sourcing method for verification of scientific data and results. The current challenges, website and biological network models were developed and are maintained as part of a collaboration among Selventa, OrangeBus and ADS. The project is led and funded by Philip Morris International. For more information on the focus of Philip Morris International’s research, please visit www.pmi.com.
Number Nodes
37
Number Edges
60
Number Components
9
Network Density
0.045045
Average Degree
1.62162
Number Citations
27
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 30%
Selventa Protein Families Definitions v20150611 30%
Hedgehog-2.0-Hs v2.0 30%
Hedgehog-2.0-Mm v2.0 30%
Growth Factor-2.0-Rn v2.0 27%
Cell Cycle-2.0-Rn v2.0 24%
PGE2-2.0-Rn v2.0 24%
PGE2-2.0-Hs v2.0 22%
PGE2-2.0-Mm v2.0 22%
Fibrosis-2.0-Rn v2.0 22%

Sample Edges

act(p(SFAM:"AKT Family"), ma(kin)) decreases act(p(SFAM:"GSK3 Family"), ma(kin))

AKT activation resulted in the phosphorylation-dependent inactivation of glycogen synthase kinase (GSK-3) (serine 21/9). PubMed:11254732

act(p(SFAM:"AKT Family"), ma(kin)) decreases act(p(SFAM:"GSK3 Family"), ma(kin))

RTK signaling potentiates GLI activity through PI3K-AKT-mediated GSK3 inactivation or RAS-STIL1-mediated SUFU inactivation, while GPCR signaling to Gs represses GLI activity through adenylate cyclase-mediated PKA activation PubMed:19860666

a(SCHEM:"cyclic AMP") directlyIncreases act(p(SFAM:"PRKA Family"), ma(kin))

Because Rap1b is one of the proteins that become phosphorylated by PKA upon elevation of intracellular cAMP levels, we evaluated the effect of the absence of Rap1b in platelets on cAMP-induced inhibition of AYPGKF peptide-induced platelet aggregation (Figure ?(Figure4C).4C). PubMed:15696195

a(SCHEM:"cyclic AMP") directlyIncreases act(p(SFAM:"PRKA Family"), ma(kin))

Insulin also profoundly inhibits lipolysis in adipocytes, primarily through inhibition of the enzyme hormone sensitive lipase71. This enzyme is acutely regulated by control of its phosphorylation state, which is activated by PKA-dependent phosphorylation, and inhibited as a result of a combination of kinase inhibition and phosphatase activation. Insulin inhibits the activity of the lipase primarily through reductions in cAMP levels, owing to the activation of a cAMP-specific phosphodiesterase in fat cells72. PubMed:11742412

a(SCHEM:"cyclic AMP") directlyIncreases act(p(SFAM:"PRKA Family"), ma(kin))

Cyclic AMP activates PKA, therefore we expect to see an increased difference between active and inactive PKA when cAMP levels are physiologically high. PubMed:19607691

Sample Nodes

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.