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  3. composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine))

composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine))

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The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

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Out-Edges 3

composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) hasComponent a(CHEBI:Nilvadipine) View Subject | View Object

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composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) hasComponent a(CHEBI:"phorbol 13-acetate 12-myristate") View Subject | View Object

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composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Weobserved that (-)-nilvadipine inhibits NFkB activation in response to TNFα (Fig. 4A) or phorbol 12-myristate 13-acetate (PMA) (Fig. 4B) by using an NFkB-luciferase reporter cell line to monitor NFkB activation, thus suggesting a possible mechanism responsible for the inhibition of BACE-1 transcription following nilvadipine treatment PubMed:25331948

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.