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p(HGNC:BDNF)

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Entity

Name
BDNF
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

In-Edges 3

p(HGNC:CHRNA7) association p(HGNC:BDNF) View Subject | View Object

BDNF can also influence the level of α7 AChRs subunits (Fig. 4) in the hippocampus and other brain regions [160,164,165]. PubMed:22040696

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Hippocampus

composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) hasComponent p(HGNC:BDNF) View Subject | View Object

Appears in Networks:

composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:BDNF)) View Subject | View Object

Stimulation with the Aβ25-35 fragments induces secretion of cytokines such as TNF-α and of neurotrophic factors such as nerve growth factor (NGF) and brain derived nerve factor (BDNF) in NF-κB-dependent manner PubMed:25652642

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 13

p(HGNC:BDNF) regulates bp(GO:"peripheral nervous system development") View Subject | View Object

BDNF regulates development of neuronal structures both in the pe- ripheral and central nervous systems [150–155]. PubMed:22040696

Appears in Networks:

p(HGNC:BDNF) regulates bp(GO:"central nervous system development") View Subject | View Object

BDNF regulates development of neuronal structures both in the pe- ripheral and central nervous systems [150–155]. PubMed:22040696

Appears in Networks:

p(HGNC:BDNF) increases bp(GO:"regulation of synaptic plasticity") View Subject | View Object

It has acute effects on the synapse, serving as an activity-dependent regulator of synaptic plas- ticity and participating in rapid synaptic transmission [150,151,156–159], in the maturation of GABAergic signaling and in the stabilization of newly formed synapses [151,160–163]. PubMed:22040696

Appears in Networks:

p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission") View Subject | View Object

It has acute effects on the synapse, serving as an activity-dependent regulator of synaptic plas- ticity and participating in rapid synaptic transmission [150,151,156–159], in the maturation of GABAergic signaling and in the stabilization of newly formed synapses [151,160–163]. PubMed:22040696

Appears in Networks:

p(HGNC:BDNF) increases bp(GO:"synaptic transmission, GABAergic") View Subject | View Object

It has acute effects on the synapse, serving as an activity-dependent regulator of synaptic plas- ticity and participating in rapid synaptic transmission [150,151,156–159], in the maturation of GABAergic signaling and in the stabilization of newly formed synapses [151,160–163]. PubMed:22040696

Appears in Networks:

p(HGNC:BDNF) increases bp(GO:"maintenance of synapse structure") View Subject | View Object

It has acute effects on the synapse, serving as an activity-dependent regulator of synaptic plas- ticity and participating in rapid synaptic transmission [150,151,156–159], in the maturation of GABAergic signaling and in the stabilization of newly formed synapses [151,160–163]. PubMed:22040696

Appears in Networks:

p(HGNC:BDNF) association p(HGNC:CHRNA7) View Subject | View Object

BDNF can also influence the level of α7 AChRs subunits (Fig. 4) in the hippocampus and other brain regions [160,164,165]. PubMed:22040696

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Hippocampus

p(HGNC:BDNF) increases p(HGNC:CHRNA7) View Subject | View Object

Recent studies using dissociated rat hippocampal neurons in culture demonstrated that BDNF increases both surface and internal α7 AChRs pools. PubMed:22040696

Appears in Networks:

p(HGNC:BDNF) increases surf(p(HGNC:CHRNA7)) View Subject | View Object

Recent studies using dissociated rat hippocampal neurons in culture demonstrated that BDNF increases both surface and internal α7 AChRs pools. PubMed:22040696

Appears in Networks:

p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease") View Subject | View Object

Receiver-operating characteristic curves and logistic regression analyses showed that combined assessment of DYRK1A, BDNF and homocysteine has a sensitivity of 0.952, a specificity of 0.889 and an accuracy of 0.933 in testing for AD. The blood levels of these markers provide a diagnosis assessment profile. Combined assessment of these three markers outperforms most of the previous markers and could become a useful substitute to the current panel of AD biomarkers. PubMed:28632203

Appears in Networks:
Annotations
Uberon
blood plasma
MeSH
Alzheimer Disease

p(HGNC:BDNF) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Both, brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) promote neurite outgrowth, in a NF- κB - dependent manner, in primary cultures of nodose ganglion sensory neurons from developing mice PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:BDNF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Both, brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) promote neurite outgrowth, in a NF- κB - dependent manner, in primary cultures of nodose ganglion sensory neurons from developing mice PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:BDNF) increases act(p(HGNC:SRC)) View Subject | View Object

The mechanism underlying the effect of BDNF and CNTF on NF-κB activation has been attributed to the activation of Src and Lck non-receptor tyrosine kinases which phosphorylate IκBα on Tyr42 resulting in subsequent NF-κB activation PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.