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a(MESH:Cytokines)

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Entity

Name
Cytokines
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 5

Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 25

a(CHEBI:Anatabine) decreases a(MESH:Cytokines) View Subject | View Object

This particular dosage was selected from a previous study showing that this dosage is efficient at lowering brain cytokine levels in a mouse model of Alzheimer’s disease displaying chronic neuroinflammation PubMed:23383175

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

a(CHEBI:"alpha-tocopherol") decreases a(MESH:Cytokines) View Subject | View Object

Reduction of A expression and cytotoxic-ity stimulated by A in neuroblastoma cells and the inhibition of inflammatory cytokines, ROS and NO in microglial cells were detected upon treatment with -tocopherol [210]. PubMed:29179999

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell

a(PUBCHEM:102336202) decreases a(MESH:Cytokines) View Subject | View Object

Furthermore, it inhibited pro-inflammatory cytokines, which were induced by A 25-35/IFN- in microglia cells [248]. PubMed:29179999

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell

a(PUBCHEM:73078) decreases a(MESH:Cytokines) View Subject | View Object

Tetrandrine inhibited the activity of NF-B and down-regulated the expression of pro-inflammatory cytokines [178–180]. PubMed:29179999

Appears in Networks:

act(p(FPLX:NFkappaB)) increases a(MESH:Cytokines) View Subject | View Object

Inhibition of NF-κB leads to decreased induction of cytokines and chemokines by IL-1β and TNF-α. PubMed:27288790

Appears in Networks:

p(HGNC:IL1B) increases a(MESH:Cytokines) View Subject | View Object

Inhibition of NF-κB leads to decreased induction of cytokines and chemokines by IL-1β and TNF-α. PubMed:27288790

Appears in Networks:

p(HGNC:TNF) increases a(MESH:Cytokines) View Subject | View Object

Inhibition of NF-κB leads to decreased induction of cytokines and chemokines by IL-1β and TNF-α. PubMed:27288790

Appears in Networks:

act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines)) View Subject | View Object

Excessive accumulation of Aβ1-42 stimulates microglial cells by signaling via receptor associated advanced glycation end products (RAGE) and peroxisome proliferator-activated receptor-γ (PPAR-γ), phosphorylates IKK proteins, and enhances NF-κB mediated transactivation of inflammatory cytokines and neurotoxic molecules such as glutamate and reactive oxygen species (ROS)/induced nitric oxide synthase (iNOS) [12] (Fig 2B) PubMed:25652642

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"iron coordination entity") positiveCorrelation a(MESH:Cytokines) View Subject | View Object

Furthermore, cytokine secretion depends on the coordinated iron in the porphyrin ring (Figueiredo et al, 2007), and nuclear factor-jB (NF-jB), MAPKs activation and ROS are essential for the increase in cytokine production induced by haem (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:heme) positiveCorrelation a(MESH:Cytokines) View Subject | View Object

Free heme has been proved possess pro-inflammatory activities, such as leukocyte activation, migration and infiltration, adhesion molecules activation, and cytokines and acute phase proteins induction [17, 18]. PubMed:24464629

Appears in Networks:
Annotations
MeSH
Kidney
Text Location
Introduction

a(CHEBI:heme) increases a(MESH:Cytokines) View Subject | View Object

Heme amplifies cytokines induced by cell surface receptors (TLR2, TLR4, TLR5), endosome receptors (TLR3, TLR9), and cytosolic receptors (NOD1 and NOD2). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(CHEBI:lipopolysaccharide) increases a(MESH:Cytokines) View Subject | View Object

Transfusion of RBCs after prolonged refrigerator storage is associated with haemolysis (Donadee et al, 2011; Hod et al, 2011) and enhances cytokine secretion in response to lipopolysaccharide (LPS) administration (Hod et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(MESH:Cytokines) View Subject | View Object

Furthermore, cytokine secretion depends on the coordinated iron in the porphyrin ring (Figueiredo et al, 2007), and nuclear factor-jB (NF-jB), MAPKs activation and ROS are essential for the increase in cytokine production induced by haem (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:ferrylhemoglobin) causesNoChange a(MESH:Cytokines) View Subject | View Object

Moreover, ferrylHb is unable to induce cytokine secretion by endothelial cells (Silva et al., 2009), another difference to heme which induces IL-8 production (Natarajan et al., 2007). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

a(MESH:hemozoin) increases a(MESH:Cytokines) View Subject | View Object

Similarly to heme, Hz also induces the production of several inflammatory mediators by macrophages such as cytokines and chemokines, and induces leukocytes migration (reviewed by Olivier et al., 2014). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

bp(GO:"endothelial cell activation") association a(MESH:Cytokines) View Subject | View Object

Finally, the cytokines produced through these pathways can then affect endothelial activation, leucocyte recruitment, and ultimately thrombotic risk. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

p(HGNC:CD40LG) increases a(MESH:Cytokines) View Subject | View Object

Furthermore, haem-induced release of P-selectin and VWF is mediated by TLR4 and NFkB signalling. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

complex(a(MESH:Lipopolysaccharides), p(HGNC:HBB)) increases a(MESH:Cytokines) View Subject | View Object

Hb synergizes with LPS enhancing the production of pro-inflammatory cytokines by macrophages (Yang et al., 2002). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

p(HGNC:MAPK1) increases a(MESH:Cytokines) View Subject | View Object

Furthermore, cytokine secretion depends on the coordinated iron in the porphyrin ring (Figueiredo et al, 2007), and nuclear factor-jB (NF-jB), MAPKs activation and ROS are essential for the increase in cytokine production induced by haem (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

p(HGNC:AMBP) positiveCorrelation a(MESH:Cytokines) View Subject | View Object

However, with A1M increased in both synovial fluid and serum in AIA, the present study further suggests that, in addition to heme and ROS, A1M may be regulated by inflammatory cytokines. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:NFKB1) increases a(MESH:Cytokines) View Subject | View Object

Furthermore, cytokine secretion depends on the coordinated iron in the porphyrin ring (Figueiredo et al, 2007), and nuclear factor-jB (NF-jB), MAPKs activation and ROS are essential for the increase in cytokine production induced by haem (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

p(HGNC:NOD1) increases a(MESH:Cytokines) View Subject | View Object

Haem increases lethality and cytokine secretion induced by LPS in vivo and enhances cytokine secretion by macrophages stimulated with various innate immune receptor agonists (e.g., TLR2, TLR9, TLR3, and nucleotide-binding oligomerization domain (NOD) agonists) (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

p(HGNC:TLR2) increases a(MESH:Cytokines) View Subject | View Object

Haem increases lethality and cytokine secretion induced by LPS in vivo and enhances cytokine secretion by macrophages stimulated with various innate immune receptor agonists (e.g., TLR2, TLR9, TLR3, and nucleotide-binding oligomerization domain (NOD) agonists) (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

p(HGNC:TLR3) increases a(MESH:Cytokines) View Subject | View Object

Haem increases lethality and cytokine secretion induced by LPS in vivo and enhances cytokine secretion by macrophages stimulated with various innate immune receptor agonists (e.g., TLR2, TLR9, TLR3, and nucleotide-binding oligomerization domain (NOD) agonists) (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

p(HGNC:TLR9) increases a(MESH:Cytokines) View Subject | View Object

Haem increases lethality and cytokine secretion induced by LPS in vivo and enhances cytokine secretion by macrophages stimulated with various innate immune receptor agonists (e.g., TLR2, TLR9, TLR3, and nucleotide-binding oligomerization domain (NOD) agonists) (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

Out-Edges 12

a(MESH:Cytokines) increases act(p(FPLX:"IKK_complex")) View Subject | View Object

Under different envi- ronmental conditions such as Aβ/ROS/cytokines accumulation, the IκB kinase (IKK) complex becomes activated and mediates the phosphoryla- tion of IκBs, then IκBs are degradated and the remaining NF-κB dimer is activated and thus translocates to the nucleus where it binds to the DNA consensus sequence of various target genes [9–11]. PubMed:27288790

Appears in Networks:

a(MESH:Cytokines) increases m(MIRBASE:"hsa-mir-155") View Subject | View Object

Moreover, miRNA-155 is strongly and rapidly up-regulated by inflammatory cytokines and also is an inducible miRNA under transcriptional control by NF-κB. PubMed:27288790

Appears in Networks:

a(MESH:Cytokines) increases bp(GO:vasodilation) View Subject | View Object

The cytokines released can further lead to pronounced peripheral vasodilation with arterial hypotension by activating the inducible nitric oxide (NO) synthase (iNOS) and the subsequent formation of NO [30]. PubMed:29956069

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Sepsis
Text Location
Review

a(MESH:Cytokines) positiveCorrelation a(CHEBI:heme) View Subject | View Object

Free heme has been proved possess pro-inflammatory activities, such as leukocyte activation, migration and infiltration, adhesion molecules activation, and cytokines and acute phase proteins induction [17, 18]. PubMed:24464629

Appears in Networks:
Annotations
MeSH
Kidney
Text Location
Introduction

a(MESH:Cytokines) positiveCorrelation a(CHEBI:"iron coordination entity") View Subject | View Object

Furthermore, cytokine secretion depends on the coordinated iron in the porphyrin ring (Figueiredo et al, 2007), and nuclear factor-jB (NF-jB), MAPKs activation and ROS are essential for the increase in cytokine production induced by haem (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:Cytokines) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Furthermore, cytokine secretion depends on the coordinated iron in the porphyrin ring (Figueiredo et al, 2007), and nuclear factor-jB (NF-jB), MAPKs activation and ROS are essential for the increase in cytokine production induced by haem (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:Cytokines) association bp(GO:"endothelial cell activation") View Subject | View Object

Finally, the cytokines produced through these pathways can then affect endothelial activation, leucocyte recruitment, and ultimately thrombotic risk. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:Cytokines) increases path(MESH:Thrombosis) View Subject | View Object

Finally, the cytokines produced through these pathways can then affect endothelial activation, leucocyte recruitment, and ultimately thrombotic risk. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:Cytokines) increases bp(MESH:"Platelet Activation") View Subject | View Object

Platelets may be activated during haemolysis by several different mechanisms involving decreased NO levels, increased pro-inflammatory cytokines and mediators, and ROS. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:Cytokines) increases path(MESH:Hypotension) View Subject | View Object

The cytokines released can further lead to pronounced peripheral vasodilation with arterial hypotension by activating the inducible nitric oxide (NO) synthase (iNOS) and the subsequent formation of NO [30]. PubMed:29956069

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Sepsis
Text Location
Review

a(MESH:Cytokines) increases path(MESH:"Blood Coagulation Disorders") View Subject | View Object

Furthermore, a massive release of cytokines will shift the balance between pro- and anti-coagulatory factors in the blood, which will lead to increased coagulation of the blood (coagulopathy). PubMed:29956069

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Sepsis
Text Location
Review

a(MESH:Cytokines) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

However, with A1M increased in both synovial fluid and serum in AIA, the present study further suggests that, in addition to heme and ROS, A1M may be regulated by inflammatory cytokines. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.