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bp(GO:"positive regulation of synaptic plasticity")

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Entity

Name
positive regulation of synaptic plasticity
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 4

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

In-Edges 6

a(CHEBI:"pregnenolone sulfate") increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

Pregnenolone sulfate (PREGS) is an endogenous steroid known to ameliorate cognitive performance in animals. PREGS is a modulator of synaptic plasticity, acting on the activation of glutamatergic transmission (Smith et al., 2014) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

This enhancement of synaptic plasticity and the activation of intracellular pathways are mediated by the activation of alpha7 nAChRs (Dineley et al., 2001; Parri et al., 2011; Plant et al., 2003; Puzzo et al., 2008) PubMed:25514383

Appears in Networks:

a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

It was proposed that the positive action of PREGS is mediated by alpha7 nAChR PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(FPLX:CHRN) increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

Through these postsynaptic effects and by influencing neural excitability, nAChRs can modulate or induce synaptic plasticity (Yakel, 2014) PubMed:28445721

Appears in Networks:

complex(GO:"NF-kappaB complex") increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

Given the indispensable role of NF-κB proteins in synaptic transmission and synaptic plasticity, it is not surprising that NF-κB is plays an indispensable role in cognition and behavior as well PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

In conditional neuronal NF-κB-deficient mice, loss of NF-κB signaling impaired synaptic transmission, spatial memory formation, and plasticity PubMed:25652642

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Out-Edges 0

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.