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p(HGNC:PRKACA)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PRKACA
Namespace
HGNC
Namespace Version
20180215
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hgnc/hgnc-20180215.belns

Appears in Networks 3

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5 v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

In-Edges 3

a(GO:microtubule) association p(HGNC:PRKACA) View Subject | View Object

In this regard, cdk5 is similar to PKA [30], MAP kinase, and GSK-3 [12,17,26], but distinct from PKC or CaMK which do not copurify with microtubules [34] PubMed:8282104

Appears in Networks:
Annotations
Confidence
High

a(HBP:HBP00006) association p(HGNC:PRKACA) View Subject | View Object

In this regard, cdk5 is similar to PKA [30], MAP kinase, and GSK-3 [12,17,26], but distinct from PKC or CaMK which do not copurify with microtubules [34] PubMed:8282104

Appears in Networks:
Annotations
Confidence
High

complex(GO:"NF-kappaB complex") increases act(p(HGNC:PRKACA)) View Subject | View Object

The molecular mechanisms underlying the aforementioned involvement of NF-κB proteins in learning and memory have not been completely comprehended, although recent evidence has implicated NF-κB – induced transcriptional activation of Protein Kinase A (PKA) catalytic subunit that culminates in activation of CREB (cyclic AMP-response element binding protein) signaling [77] which is regarded as the molecular switch that converts short-term memory to long-term memory PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 4

p(HGNC:PRKACA) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

In support of this, protein kinase A (PKA) has similar effects on reducing Abeta generation and stimulating the budding of APP-containing vesicles from the TGN [207] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Cell Membrane
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

p(HGNC:PRKACA) association a(GO:microtubule) View Subject | View Object

In this regard, cdk5 is similar to PKA [30], MAP kinase, and GSK-3 [12,17,26], but distinct from PKC or CaMK which do not copurify with microtubules [34] PubMed:8282104

Appears in Networks:
Annotations
Confidence
High

p(HGNC:PRKACA) association a(HBP:HBP00006) View Subject | View Object

In this regard, cdk5 is similar to PKA [30], MAP kinase, and GSK-3 [12,17,26], but distinct from PKC or CaMK which do not copurify with microtubules [34] PubMed:8282104

Appears in Networks:
Annotations
Confidence
High

act(p(HGNC:PRKACA)) increases act(p(HGNC:CREB1)) View Subject | View Object

The molecular mechanisms underlying the aforementioned involvement of NF-κB proteins in learning and memory have not been completely comprehended, although recent evidence has implicated NF-κB – induced transcriptional activation of Protein Kinase A (PKA) catalytic subunit that culminates in activation of CREB (cyclic AMP-response element binding protein) signaling [77] which is regarded as the molecular switch that converts short-term memory to long-term memory PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.