1. Catalog
  2. Nodes
  3. p(HGNC:CNTF)

p(HGNC:CNTF)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CNTF
Namespace
hgnc
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/hgnc-names.belns

Appears in Networks 1

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

In-Edges 1

complex(GO:"NF-kappaB complex") increases p(HGNC:CNTF) View Subject | View Object

NF-κB positively regulates the transcription of interleukin 6 (IL6) family of cytokines such as IL6, leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) [184], which in-turn induce the differentiation of NSC into astrocytes by activating transcription factors STAT3, AP-1, and NF-κB itself PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 7

p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Both, brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) promote neurite outgrowth, in a NF- κB - dependent manner, in primary cultures of nodose ganglion sensory neurons from developing mice PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:CNTF) increases bp(GO:"astrocyte development") View Subject | View Object

NF-κB positively regulates the transcription of interleukin 6 (IL6) family of cytokines such as IL6, leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) [184], which in-turn induce the differentiation of NSC into astrocytes by activating transcription factors STAT3, AP-1, and NF-κB itself PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:CNTF) increases p(HGNC:STAT3) View Subject | View Object

NF-κB positively regulates the transcription of interleukin 6 (IL6) family of cytokines such as IL6, leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) [184], which in-turn induce the differentiation of NSC into astrocytes by activating transcription factors STAT3, AP-1, and NF-κB itself PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:CNTF) increases a(MESH:"Transcription Factor AP-1") View Subject | View Object

NF-κB positively regulates the transcription of interleukin 6 (IL6) family of cytokines such as IL6, leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) [184], which in-turn induce the differentiation of NSC into astrocytes by activating transcription factors STAT3, AP-1, and NF-κB itself PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

NF-κB positively regulates the transcription of interleukin 6 (IL6) family of cytokines such as IL6, leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) [184], which in-turn induce the differentiation of NSC into astrocytes by activating transcription factors STAT3, AP-1, and NF-κB itself PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:CNTF) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Both, brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) promote neurite outgrowth, in a NF- κB - dependent manner, in primary cultures of nodose ganglion sensory neurons from developing mice PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:CNTF) increases act(p(HGNC:LCK)) View Subject | View Object

The mechanism underlying the effect of BDNF and CNTF on NF-κB activation has been attributed to the activation of Src and Lck non-receptor tyrosine kinases which phosphorylate IκBα on Tyr42 resulting in subsequent NF-κB activation PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.