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p(HGNC:MAP2)

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Entity

Name
MAP2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 4

p(HGNC:MAPT, var("p.Ala152Thr")) increases p(HGNC:MAP2) View Subject | View Object

Four weeks after terminal differentiation, 80% of cells were positive for the neuron-specific marker MAP2, and there was no significant difference between control and patient neurons (Figure S2A) PubMed:27594586

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Frontotemporal Dementia

g(DBSNP:rs63751011) increases p(HGNC:MAP2) View Subject | View Object

Four weeks after terminal differentiation, 80% of cells were positive for the neuron-specific marker MAP2, and there was no significant difference between control and patient neurons (Figure S2A) PubMed:27594586

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Frontotemporal Dementia

complex(GO:"NF-kappaB complex") increases p(HGNC:MAP2) View Subject | View Object

NF-κB activates the expression of the two microtubule-associated proteins, microtubule-associated protein 1B (MAP1B) and microtubule-associated protein 2 (MAP2) [209], two major proteins known to play a pivotal role in the growth, elongation, and arborization of dendrites PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:Schizophrenia) decreases p(HGNC:MAP2) View Subject | View Object

Notably, a marked reduction in MAP2 immunoreactivity, along with a decrease in dendritic arbor, is reported in the primary auditory cortex (BA41) of schizophrenic subjects compared with healthy controls PubMed:30061532

Appears in Networks:
Annotations
MeSH
Auditory Cortex

Out-Edges 6

p(HGNC:MAP2) hasVariant p(HGNC:MAP2, frag("332_339")) View Subject | View Object

Appears in Networks:

p(HGNC:MAP2) hasVariant p(HGNC:MAP2, pmod(Ac)) View Subject | View Object

Appears in Networks:

p(HGNC:MAP2) increases a(MESH:"Dendritic Cells") View Subject | View Object

NF-κB activates the expression of the two microtubule-associated proteins, microtubule-associated protein 1B (MAP1B) and microtubule-associated protein 2 (MAP2) [209], two major proteins known to play a pivotal role in the growth, elongation, and arborization of dendrites PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:MAP2) increases a(GO:microtubule) View Subject | View Object

Among various identified MAPs, microtubule-associated protein 2 (MAP2), which belongs to the MAP2/Tau family, is enriched in the brain and especially in dendrites, where it contributes to microtubule stabilization and overall dendritic architecture. PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Dendrites

p(HGNC:MAP2) increases bp(GO:"dendritic spine organization") View Subject | View Object

Among various identified MAPs, microtubule-associated protein 2 (MAP2), which belongs to the MAP2/Tau family, is enriched in the brain and especially in dendrites, where it contributes to microtubule stabilization and overall dendritic architecture. PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Dendrites

p(HGNC:MAP2) increases bp(GO:"cytoskeleton organization") View Subject | View Object

Alterations in MAP2 immunoreactivity within the subiculum, entorhinal cortex, hippocampus, and prefrontal cortex have been suggested as the primary array of cytoskeletal abnormalities, which in turn result in impaired neurotransmission observed in schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Entorhinal Cortex
MeSH
Hippocampus
MeSH
Prefrontal Cortex

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.