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CA3 Region, Hippocampal

Name
CA3 Region, Hippocampal
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

act(p(HGNC:CHRNA7, loc(GO:"axon terminus"))) regulates bp(GO:"synaptic transmission, glycinergic") View Subject | View Object

In CA1 and CA3 pyramidal neurons of the developed hippocampus, alpha7 nAChRs are expressed primarily on axon terminals whereby their activation modulates the efficacy of glutamate synaptic transmission. PubMed:19126755

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal
MeSH
CA3 Region, Hippocampal
MeSH
Pyramidal Cells
Text Location
Review

act(complex(GO:"GABA-A receptor complex")) increases bp(GO:"membrane depolarization") View Subject | View Object

In the rat CA3 region, spontaneous activation of GABA A receptors produces giant depolarizing potentials, whose frequency is controlled by α7∗ and non-α7 nAChRs. PubMed:17009926

Appears in Networks:
Annotations
MeSH
CA3 Region, Hippocampal

p(FPLX:CHRN) regulates act(complex(GO:"GABA-A receptor complex")) View Subject | View Object

In the rat CA3 region, spontaneous activation of GABA A receptors produces giant depolarizing potentials, whose frequency is controlled by α7∗ and non-α7 nAChRs. PubMed:17009926

Appears in Networks:
Annotations
MeSH
CA3 Region, Hippocampal

p(MGI:Chrm4) decreases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) View Subject | View Object

Corroborating this hypothesis, it has been demonstrated that dopamine efflux is increased in the nucleus accumbens of M4 knockout mice PubMed:26813123

Appears in Networks:
Annotations
MeSH
CA3 Region, Hippocampal

path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Cognitive Dysfunction") View Subject | View Object

In addition to cognitive alterations, psychiatric symptoms are frequently observed in AD patients, including apathy and depression PubMed:26813123

Appears in Networks:
Annotations
MeSH
CA3 Region, Hippocampal

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.