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p(HGNC:C3)

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Entity

Name
C3
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-b peptide and s levels: target engagement, tolerability and pharmacokinetics in humans v0.1.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(PUBCHEM:11249342) decreases p(HGNC:C3) View Subject | View Object

A significant lowering of pro-inflammatory, C3 (86.9%) and microglial activation markers, MCP-1 (87.5%) and YKL-40 (72.7%), was evident. PubMed:22791904

Appears in Networks:

complex(GO:"NF-kappaB complex") regulates p(HGNC:C3) View Subject | View Object

NF-κB directly regulates the transcription of a multitude of proteins of the complement pathway that are involved in antigen presenting such as C3 (complement component 3) [241], Bf (complement factor B) [242], and CR2 (complement receptor 2) [243] as well as acute phase proteins such as C4 (complement factor 4) [244] and C4BPA (complement factor 4 binding protein) PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:heme) increases p(HGNC:C3) View Subject | View Object

Furthermore, the incubation of serum or whole blood with heme induces deposition of activation fragments (C3b, iC3b, C3dg) of complement component 3 (C3) at the surface of erythrocytes [77]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Anemia, Sickle Cell
Text Location
Review

complex(a(CHEBI:heme), a(CHEBI:thioester)) increases p(HGNC:C3) View Subject | View Object

Molecular docking predicted the interaction of heme in close proximity to a thioester bond, known to be important for the activation of C3. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Malaria
Text Location
Review

complex(a(CHEBI:heme), p(PFAM:C1q)) decreases act(p(HGNC:C3)) View Subject | View Object

However, in contrast to its effect on C3, exposure of C1q to heme was demonstrated to inhibit its functions in vitro [89,90] (Figure 3B). PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Malaria
Text Location
Review

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.