1. Catalog
  2. Nodes
  3. complex(p(HGNC:CDK5), p(HGNC:CDK5R1))

complex(p(HGNC:CDK5), p(HGNC:CDK5R1))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 3

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 3

p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) View Subject | View Object

To perform its function, Cdk5 must bind to the neuron-specific regulatory subunit protein p35, which is beneficial for neuronal development (Tsai et al. 1994; Chae et al. 1997). However, truncation of p35 and conversion to p25 (Patrick et al. 1999) is found in the forebrain of rats after focal cerebral ischemia and in AD patients, and these alterations are deleterious to the brain PubMed:26118667

Appears in Networks:

p(HGNC:CDK5R1) partOf complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) View Subject | View Object

Appears in Networks:

complex(GO:"NF-kappaB complex") increases act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) View Subject | View Object

Furthermore, NF-κB - induced IL6 has been demonstrated to evoke hyperphosphorylation of tau at Ser202 and Thr205 via the activation of the cdk5/p35 complex PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 4

complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) hasComponent p(HGNC:CDK5) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5)) View Subject | View Object

To perform its function, Cdk5 must bind to the neuron-specific regulatory subunit protein p35, which is beneficial for neuronal development (Tsai et al. 1994; Chae et al. 1997). However, truncation of p35 and conversion to p25 (Patrick et al. 1999) is found in the forebrain of rats after focal cerebral ischemia and in AD patients, and these alterations are deleterious to the brain PubMed:26118667

Appears in Networks:

complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) hasComponent p(HGNC:CDK5R1) View Subject | View Object

Appears in Networks:

act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Furthermore, NF-κB - induced IL6 has been demonstrated to evoke hyperphosphorylation of tau at Ser202 and Thr205 via the activation of the cdk5/p35 complex PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.