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path(MESH:Hypoxia)

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Entity

Name
Hypoxia
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mesh-names.belns

Appears in Networks 2

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 9

bp(HM:"Renal Blood Flow, limited") increases path(MESH:Hypoxia) View Subject | View Object

By contrast, no or limited increases in renal blood flow are observed during acute hemodilution (15, 42), leading to earlier and more severe renal tissue hypoxia (5, 38), and an increase in the magnitude of hypoxia signaling responses, including stabilization of the transcription factor hypoxia- inducible factor- (HIF-) (42, 43). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
Text Location
Introduction

bp(HM:"Renal Blood Flow, limited") increases path(MESH:Hypoxia) View Subject | View Object

The absent or relatively small increase in renal blood flow likely contributed to the occurrence of renal tissue hypoxia in both models. PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
Text Location
Discussion

bp(HM:"Renal Blood Flow, limited") increases path(MESH:Hypoxia) View Subject | View Object

The renal blood flow response to anemia is proportionally much smaller than the increase observed in cerebral blood flow (50–100%). This relative difference in organ blood flow likely explains why the kidney becomes profoundly hypoxic, whereas brain oxygenation is largely preserved during anemia (12, 32, 42). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

bp(HM:"Renal Blood Flow, limited") increases path(MESH:Hypoxia) View Subject | View Object

Our data provided clear evidence of renal tissue hypoxia, which was in part due to a lack of increase in renal blood flow. PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

path(HM:"Anemia, acute") positiveCorrelation path(MESH:Hypoxia) View Subject | View Object

However, as reviewed above, several experimental tal studies and our new data have demonstrated that both acute and subacute anemia are associated with renal tissue hypoxia (5, 38, 41, 43). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

path(HM:"Anemia, subacute") positiveCorrelation path(MESH:Hypoxia) View Subject | View Object

However, as reviewed above, several experimental tal studies and our new data have demonstrated that both acute and subacute anemia are associated with renal tissue hypoxia (5, 38, 41, 43). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

path(HM:"vaso-occlusive crisis") positiveCorrelation path(MESH:Hypoxia) View Subject | View Object

Depending on the extension of the vaso-occlusion, some tissues may experience hypoxia and damage. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

path(HM:"vaso-occlusive crisis") positiveCorrelation path(MESH:Hypoxia) View Subject | View Object

Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

path(MESH:Anemia) increases path(MESH:Hypoxia) View Subject | View Object

Our experimental data provided clear evidence that moderate subacute anemia resulted in a profound level of renal tissue hypoxia, as characterized by a reduction in kidney PtO2, an increase in regional HIF/luciferase radiance in vivo, and a substantial increase in EPO mRNA level at a Hb concentration consistent with moderate anemia (90 g/l). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
Text Location
Discussion

Out-Edges 7

path(MESH:Hypoxia) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Physiological, pathophysiological, and biochemical stimuli known to induce proliferation of NPC via NF-κB activation include cerebral infarction [165], traumatic brain injury [166], reactive oxygen species [167], hypoxia [168-172], sAPPα [147], and sphingosine-1-phosphate [173] PubMed:28745240

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

path(MESH:Hypoxia) increases bp(GO:neurogenesis) View Subject | View Object

Physiological, pathophysiological, and biochemical stimuli known to induce proliferation of NPC via NF-κB activation include cerebral infarction [165], traumatic brain injury [166], reactive oxygen species [167], hypoxia [168-172], sAPPα [147], and sphingosine-1-phosphate [173] PubMed:28745240

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Alzheimer Disease

path(MESH:Hypoxia) positiveCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Depending on the extension of the vaso-occlusion, some tissues may experience hypoxia and damage. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

path(MESH:Hypoxia) positiveCorrelation path(HM:"vaso-occlusive crisis") View Subject | View Object

Hp and Hpx significantly inhibited stasis in response H/R or LPS (Fig 5). PubMed:29694434

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

path(MESH:Hypoxia) positiveCorrelation path(HM:"Anemia, acute") View Subject | View Object

However, as reviewed above, several experimental tal studies and our new data have demonstrated that both acute and subacute anemia are associated with renal tissue hypoxia (5, 38, 41, 43). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

path(MESH:Hypoxia) positiveCorrelation path(HM:"Anemia, subacute") View Subject | View Object

However, as reviewed above, several experimental tal studies and our new data have demonstrated that both acute and subacute anemia are associated with renal tissue hypoxia (5, 38, 41, 43). PubMed:29351418

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Anemia
Text Location
Discussion

path(MESH:Hypoxia) increases path(HM:"Organ Dysfunction") View Subject | View Object

We observed a mild degree of plasma hypoxia could lead to organ injury. PubMed:29351418

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Anemia
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.