act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Microglia))

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PubMed:25652642

Excessive accumulation of Aβ1-42 stimulates microglial cells by signaling via receptor associated advanced glycation end products (RAGE) and peroxisome proliferator-activated receptor-γ (PPAR-γ), phosphorylates IKK proteins, and enhances NF-κB mediated transactivation of inflammatory cytokines and neurotoxic molecules such as glutamate and reactive oxygen species (ROS)/induced nitric oxide synthase (iNOS) [12] (Fig 2B)

Related Edges 13

• a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex"))
• a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation act(a(MESH:Microglia))
• a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"positive regulation of advanced glycation end-product receptor activity")
• a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"peroxisome proliferator activated receptor signaling pathway")
• a(CHEBI:"amyloid-beta polypeptide 42") increases p(MESH:"I-kappa B Proteins", pmod(Ph))
• act(a(MESH:Microglia)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42")
• bp(GO:"peroxisome proliferator activated receptor signaling pathway") increases act(a(MESH:Microglia))
• bp(GO:"positive regulation of advanced glycation end-product receptor activity") increases act(a(MESH:Microglia))
• act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines))
• act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"glutamate(1-)"))
• act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species"))
• act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2))
• p(MESH:"I-kappa B Proteins", pmod(Ph)) increases act(a(MESH:Microglia))

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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