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bp(HBP:"PI3K-Akt signaling pathway")

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Entity

Name
PI3K-Akt signaling pathway
Namespace
HBP
Namespace Version
20190206
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/3c85897632afa791ac78fb3aa2e392963ab155b1/export/hbp-names.belns

Appears in Networks 2

FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

In-Edges 5

a(CHEBI:sirolimus) decreases bp(HBP:"PI3K-Akt signaling pathway") View Subject | View Object

Genes in the mTOR pathway were also of specific interest because this pathway is inhibited by the immunosuppressant drug rapamy- cin via complex formation with FKBP1b/1a. PubMed:29255009

Appears in Networks:

act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1a))) decreases bp(HBP:"PI3K-Akt signaling pathway") View Subject | View Object

Genes in the mTOR pathway were also of specific interest because this pathway is inhibited by the immunosuppressant drug rapamy- cin via complex formation with FKBP1b/1a. PubMed:29255009

Appears in Networks:

p(MGI:Fkbp1a) decreases bp(HBP:"PI3K-Akt signaling pathway") View Subject | View Object

Moreover, FKBP1a, a close isoform of FKBP1b, negatively regulates mTOR in the brain, even in the absence of rapamycin PubMed:29255009

Appears in Networks:

act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1b))) decreases bp(HBP:"PI3K-Akt signaling pathway") View Subject | View Object

Genes in the mTOR pathway were also of specific interest because this pathway is inhibited by the immunosuppressant drug rapamy- cin via complex formation with FKBP1b/1a. PubMed:29255009

Appears in Networks:

a(CHEBI:"amyloid-beta") regulates bp(HBP:"PI3K-Akt signaling pathway") View Subject | View Object

Moreover, there is preponderance of data implicating Amyloid-β in the modulation of PKC signaling pathway [335-338] and the PI3K/Akt/mTOR signaling pathway [339-341], which are known to activate NF-κB signaling pathway PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 3

bp(HBP:"PI3K-Akt signaling pathway") causesNoChange act(p(MGI:Fkbp1b)) View Subject | View Object

Nevertheless, the lack of change in mTOR pathway gene expression suggests that FKBP1b’s genomic effects were not mediated by the mTOR pathway. PubMed:29255009

Appears in Networks:

bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

The three well characterized sensors of intracellular calcium – calmodulin/CamKII pathway, PI3K/ Akt pathway, and protein kinase C (PKC) pathway – are known to induce NF-κB activation and couple upstream signal transduction pathways that induce calcium dyshomeostasis to NF-κB activation PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Moreover, there is preponderance of data implicating Amyloid-β in the modulation of PKC signaling pathway [335-338] and the PI3K/Akt/mTOR signaling pathway [339-341], which are known to activate NF-κB signaling pathway PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.