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path(MESH:"Spatial Memory")

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Entity

Name
Spatial Memory
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/mesh-names.belns

Appears in Networks 9

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice v1.0.0

Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice v1.0.0

Adenosine A1 receptor antagonist 64627 alleviates axonopathy caused by human Tau ΔK280 v1.0.0

Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

In-Edges 19

a(CHEBI:"pregnenolone sulfate") increases path(MESH:"Spatial Memory") View Subject | View Object

The treatment improved spatial memory and reduced apoptosis in CA1 pyramidal cells PubMed:25514383

Appears in Networks:
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MeSH
Alzheimer Disease

a(CHEBI:nicotine) increases path(MESH:"Spatial Memory") View Subject | View Object

Like the young mice, they also displayed an improvement in spatial memory, demonstrating that nicotine enhances memory in both young and old mice PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") View Subject | View Object

Whilst the spatial memory deficit was restored by 4OH-GTS-21 treatment, this molecule had no effect on neuronal density (Ren et al., 2007) PubMed:25514383

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Annotations
MeSH
Alzheimer Disease

p(MGI:Chrna7) decreases path(MESH:"Spatial Memory") View Subject | View Object

This AD model displays spatial memory deficit at 13-16 months of age, while APP-alpha7KO mice did not exhibit any memory deficit, suggesting that the absence of the alpha7 subunit of the nicotinic receptor protects against the behavioural deficit caused by expression of the mutated forms of APP in this AD model PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory") View Subject | View Object

This AD model displays spatial memory deficit at 13-16 months of age, while APP-alpha7KO mice did not exhibit any memory deficit, suggesting that the absence of the alpha7 subunit of the nicotinic receptor protects against the behavioural deficit caused by expression of the mutated forms of APP in this AD model PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(MGI:Tmem35a) increases path(MESH:"Spatial Memory") View Subject | View Object

NACHO knockout mice also showed deficits of spontaneous alternation in the Y-maze compared to wild-type littermates (Figure S2E) PubMed:28445721

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a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") View Subject | View Object

Improved performance was seen each day in the Morris water task at the 2 mg/kg drug dose compared with saline-injected, lesioned animals PubMed:17640819

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a(CHEBI:galanthamine) increases path(MESH:"Spatial Memory") View Subject | View Object

The analysis also showed significant enhancing effects of PHA and Gal on the time spent in the target quadrant on comparing with the normal saline in AD mice (p<0.001). Also, in comparison with the control group, PHA-treated AD animals did not have a significant difference (p>0.05) on the time spent in the target quadrant, but in the Gal group it was significantly lower (p<0.001) (Fig. 3). PubMed:25881725

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") View Subject | View Object

The analysis also showed significant enhancing effects of PHA and Gal on the time spent in the target quadrant on comparing with the normal saline in AD mice (p<0.001). Also, in comparison with the control group, PHA-treated AD animals did not have a significant difference (p>0.05) on the time spent in the target quadrant, but in the Gal group it was significantly lower (p<0.001) (Fig. 3). PubMed:25881725

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") View Subject | View Object

MLA could completely block the PHA-induced spatial memory improvement (p<0.001). Furthermore, the effect of Gal against the Ab-impaired reference memory could be abolished by the pre-treatment of the a7 nAChR antagonist MLA (p<0.001). However, a7 nAChR blockage in the Gal group has a lesser effect on reference memory in comparison of blockage of that receptor in the PHA group (p<0.05) (Fig. 4). PubMed:25881725

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a(MESH:methyllycaconitine) decreases path(MESH:"Spatial Memory") View Subject | View Object

MLA could completely block the PHA-induced spatial memory improvement (p<0.001). Furthermore, the effect of Gal against the Ab-impaired reference memory could be abolished by the pre-treatment of the a7 nAChR antagonist MLA (p<0.001). However, a7 nAChR blockage in the Gal group has a lesser effect on reference memory in comparison of blockage of that receptor in the PHA group (p<0.05) (Fig. 4). PubMed:25881725

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p(MGI:App, frag("25_35")) decreases path(MESH:"Spatial Memory") View Subject | View Object

Time spent in target quadrant in probe trials. On the probe trial, there was a statistically significant difference between groups as determined by a one-way ANOVA (F(4,70)=35.21, p<0.001). Post hoc analysis revealed a significant effect of Ab injection on the time spent in the target quadrant, indicating that the Ab decreased the searching time in the target quadrant on comparing with the control (p<0.001). PubMed:25881725

Appears in Networks:

act(p(MGI:Chrna7)) increases path(MESH:"Spatial Memory") View Subject | View Object

Effect of a7 nAChRs blockage on time spent in target quadrant in probe trials. The implications of the a7 nAChRs on PHA- or Gal-induced spatial memory enhancement were investigated by pretreatment with normal saline or MLA. A two-way ANOVA revealed significant differences of treatment [F(1,56)=4.24, p<0.05], pretreatment [F(1,56)=96.87, p<0.001] and treatment  pretreatment interaction [F(1,32)=10.69, p<0.01]. Inter-group analysis showed that this effect was blocked by the selective a7 nAChR antagonist MLA (p<0.001). PubMed:25881725

Appears in Networks:

composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases path(MESH:"Spatial Memory") View Subject | View Object

64627 reestablished novel arm preference in proaggregant mice, suggesting that 64627 restores spatial memory in these animals PubMed:27671637

Appears in Networks:
Annotations
MeSH
Mitochondria

act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory") View Subject | View Object

This finding was associated with spatial memory dysfunction and an increase in Abeta plaque deposition PubMed:28019679

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Confidence
High
MeSH
Neurons
NeuroMMSigDB
Amyloidogenic subgraph

p(HGNC:NFKB1) increases path(MESH:"Spatial Memory") View Subject | View Object

p50 knock-out mice exhibit deficits in late LTP resulting in compromised spatial memory PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(GO:"NF-kappaB complex") increases path(MESH:"Spatial Memory") View Subject | View Object

NF-κB is also indispensable for longterm spatial memory as assessed by radial arm maze [25] and Morris water maze paradigms in mice PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:102336202) increases path(MESH:"Spatial Memory") View Subject | View Object

Xanthoceraside alleviated the A 25-35-stimulated spatial memory deficiencies and oxidative stress in mouse models [246]. PubMed:29179999

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases path(MESH:"Spatial Memory") View Subject | View Object

In conditional neuronal NF-κB-deficient mice, loss of NF-κB signaling impaired synaptic transmission, spatial memory formation, and plasticity PubMed:25652642

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Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.