Citation

PubMed: 28745240

Title: Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease.
Journal: CNS & neurological disorders drug targets
Volume: 16
Issue: None
Pages: 1050-1065
Date: 2017-01-01
Authors: Ghribi O | Marwarha G

Evidence a83424e2a1
JSON

Amyloid-β induced apoptosis has also been ascribed to dyshomeostasis of intracellular Ca2+ and oxidative stress [106-108], two critical biochemical derangements known to activate NF-κB

a(CHEBI:"amyloid-beta") decreases bp(GO:"calcium ion homeostasis") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") association bp(MESH:"Oxidative Stress") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"calcium ion homeostasis") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(MESH:"Oxidative Stress") association a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 1a67733ba7
JSON

In primary neuronal cultures, Amyloid-β has been shown to elicit oxidative stress and evoke NF-κB activation

a(CHEBI:"amyloid-beta") increases bp(MESH:"Oxidative Stress") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 63de27867f
JSON

Amyloid-β has also been demonstrated to induce apoptosis via the JNK1/c-Jun/Fas ligand signaling cascade [110], which results in NF-κB activation

a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases bp(GO:"JNK cascade") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases bp(GO:"Fas signaling pathway") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"Fas signaling pathway") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"Fas signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"JNK cascade") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"JNK cascade") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 82a4b4fd82
JSON

Recent evidence has cogently shown that Amyloid-β induces apoptosis in rat primary neurons and human post-mitotic neuronal cells by reducing Bcl-XL expression level and evoking the release of cytochrome c from the mitochondria in a NF-κB – dependent manner

a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") decreases sec(a(PUBCHEM:16057918)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Mitochondria
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases sec(a(PUBCHEM:16057918)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Mitochondria
MeSH: Alzheimer Disease

p(HGNC:BCL2L1) increases sec(a(PUBCHEM:16057918)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Mitochondria
MeSH: Alzheimer Disease

Evidence dff983455b
JSON

Furthermore, fibrillar Amyloid-β has been shown to activate NF-κB via the assembly pf the C5b-MAC complex

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases complex(a(GO:"membrane attack complex"), p(HGNC:C5)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(a(GO:"membrane attack complex"), p(HGNC:C5)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 74758c68b9
JSON

Furthermore, Amyloid-β actuates NF-κB – dependent pro-inflammatory pathways in microglia culminating in TNFα expression and subsequently TNFα effectuated neurotoxicity

a(CHEBI:"amyloid-beta") increases complex(GO:"NF-kappaB complex") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") increases p(HGNC:TNF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:TNF) increases path(HBP:neurotoxicity) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 086cc4b387
JSON

Furthermore, Amyloid-β –induced NF-κB also results in the up-regulation of the antioxidant mitochondrial membrane enzyme – MnSOD (superoxide dismutase 2) [328] which is well known to combat oxidative stress and apoptosis

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:SOD2) decreases bp(MESH:"Oxidative Stress") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:SOD2) decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 47a27ac8b1
JSON

Indeed, Checler and colleagues have shown in a recent study that, NF-κB mediates the Amyloid-β – induced increase in expression of AβPP in HEK293 cells

a(CHEBI:"amyloid-beta") increases p(HGNC:APP) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

Experimental Factor Ontology (EFO): HEK293
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

Experimental Factor Ontology (EFO): HEK293
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

Experimental Factor Ontology (EFO): HEK293
MeSH: Alzheimer Disease

Evidence f1f8fb0c4f
JSON

There is evidence that Amyloid-β causes the activation of Ca2+/calmodulin/CamKII pathway [332-334], thereby potentially leading to NF-κB activation.

a(CHEBI:"amyloid-beta") increases act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 8e97bc74ff
JSON

Moreover, there is preponderance of data implicating Amyloid-β in the modulation of PKC signaling pathway [335-338] and the PI3K/Akt/mTOR signaling pathway [339-341], which are known to activate NF-κB signaling pathway

a(CHEBI:"amyloid-beta") regulates act(p(FPLX:PKC)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(CHEBI:"amyloid-beta") regulates bp(HBP:"PI3K-Akt signaling pathway") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 6a6e176353
JSON

Furthermore, negative regulators of NF-κB such as the NAD+- dependent histone deacetylase – SIRT1, abolish the deleterious neurotoxic effects of Amyloid-β

a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:SIRT1) decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:SIRT1) decreases path(HBP:neurotoxicity) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 20cec60ea3
JSON

Emerging evidence has implicated Amyloid-β in augmenting cytosolic Ca2+ levels and causing NF- κB activation via calcineurin in astrocytes

a(CHEBI:"amyloid-beta") increases a(CHEBI:"calcium(2+)") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Cytosol
MeSH: Alzheimer Disease

a(MESH:Calcineurin) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Cytosol
MeSH: Alzheimer Disease

Evidence c1ab211b6c
JSON

Amyloid-β also induces microglial activation that results in NF-κB – induced expression of pro-inflammatory cytokines such as TNFα, IL1β, IL6, and IL8 from the microglia resulting in neuronal death

a(CHEBI:"amyloid-beta") increases act(a(MESH:Microglia)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(a(MESH:Microglia)) increases p(HGNC:TNF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(a(MESH:Microglia)) increases p(HGNC:IL1B) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(a(MESH:Microglia)) increases p(HGNC:IL6) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(a(MESH:Microglia)) increases p(HGNC:CXCL8) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(a(MESH:Microglia)) increases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:CXCL8) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:CXCL8) increases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:IL1B) increases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:IL6) increases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:TNF) increases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 32d90681a0
JSON

Additionally, NF-κB activity is also actuated by glutamate- mediated excitatory neurotransmission in the hippocampus, cerebral cortex, and the cerebellar granule cells

a(CHEBI:"glutamate(1-)") increases act(a(GO:"excitatory synapse")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Cerebral Cortex
MeSH: Hippocampus
MeSH: Alzheimer Disease

act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Cerebral Cortex
MeSH: Hippocampus
MeSH: Alzheimer Disease

Evidence d045026b3e
JSON

Furthermore, nitric oxide (NO), a well characterized repressor of NF-κB activation and signaling [174, 175], causes a mitigation in neurogenesis

a(CHEBI:"nitric oxide") decreases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

a(CHEBI:"nitric oxide") decreases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

Evidence 4b480e6467
JSON

Physiological, pathophysiological, and biochemical stimuli known to induce proliferation of NPC via NF-κB activation include cerebral infarction [165], traumatic brain injury [166], reactive oxygen species [167], hypoxia [168-172], sAPPα [147], and sphingosine-1-phosphate [173]

a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

a(CHEBI:"reactive oxygen species") increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

a(CHEBI:"sphingosine 1-phosphate") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

a(CHEBI:"sphingosine 1-phosphate") increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HBP:"sAPP-alpha") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HBP:"sAPP-alpha") increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(MESH:"Brain Injuries, Traumatic") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(MESH:"Brain Injuries, Traumatic") increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(MESH:"Cerebral Infarction") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(MESH:"Cerebral Infarction") increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(MESH:Hypoxia) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(MESH:Hypoxia) increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

Evidence c01c9ed024
JSON

Overexpression of the p65 subunit of NF-κB confers resistance to etoposide-induced apoptosis in cortical neurons

a(CHEBI:etoposide) increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Cerebral Cortex
MeSH: Neurons
MeSH: Alzheimer Disease

bp(GO:"apoptotic process") negativeCorrelation p(HGNC:RELA) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Cerebral Cortex
MeSH: Neurons
MeSH: Alzheimer Disease

p(HGNC:RELA) negativeCorrelation bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Cerebral Cortex
MeSH: Neurons
MeSH: Alzheimer Disease

Evidence ffce2889cc
JSON

NF-κB activation also protects hippocampal neurons from oxidative stress-induced apoptosis by inducing manganese superoxide dismutase (MnSOD) expression and mitigating peroxynitrite-induced protein nitration

a(CHEBI:peroxynitrite) increases p(MESH:Proteins, pmod(HBP:nitration)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases p(MESH:Proteins, pmod(HBP:nitration)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

Evidence 053b32bd64
JSON

Consequently, NF-κB is constitutively activated in the excitatory neurons of the cerebral cortex (layers 2, 4, and 5), hippocampus (granule and pyramidal neurons of CA1 and CA3), and cerebellar granule cells and this constitutive activity is indispensable for neuronal survival in response to glutamate-induced excitotoxicity

act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

path(HBP:Excitotoxicity) increases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 0231a1505c
JSON

The molecular mechanism underlying constitutive activation of NF-κB by glutamate-induced excitatory synaptic neurotransmission has been ascribed to NMDA receptor mediated Ca2+ influx and subsequent activation of CaMKII

act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates bp(GO:"calcium ion import") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates act(p(HGNC:CAMK2A)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"calcium ion import") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 97684f9bfd
JSON

Other species of NF-κB have not been found at the synapses suggesting that the synapses contain the p65-p50 heterodimer exclusively

a(GO:synapse) association complex(p(HGNC:NFKB1), p(HGNC:RELA)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(p(HGNC:NFKB1), p(HGNC:RELA)) association a(GO:synapse) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence ce66ffec15
JSON

Moreover, NF-κB mediates the NSC migration in response to physiological and pathophysiological stimuli such as cerebral cortex injury [181], seizure [182], and ischemic stroke

a(MESH:"Cerebral Cortex") negativeCorrelation act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates a(MESH:"Neural Stem Cells") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) negativeCorrelation a(MESH:"Cerebral Cortex") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(HP:"Ischemic stroke") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

path(HP:Seizures) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

Evidence 63d24a8e25
JSON

NF-κB positively regulates the transcription of interleukin 6 (IL6) family of cytokines such as IL6, leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) [184], which in-turn induce the differentiation of NSC into astrocytes by activating transcription factors STAT3, AP-1, and NF-κB itself

a(MESH:"Transcription Factor AP-1") increases bp(GO:"astrocyte development") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"astrocyte development") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:LIF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:CNTF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:CNTF) increases bp(GO:"astrocyte development") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:CNTF) increases p(HGNC:STAT3) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:CNTF) increases a(MESH:"Transcription Factor AP-1") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:IL6) increases bp(GO:"astrocyte development") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:IL6) increases p(HGNC:STAT3) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:IL6) increases a(MESH:"Transcription Factor AP-1") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:IL6) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:LIF) increases bp(GO:"astrocyte development") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:LIF) increases p(HGNC:STAT3) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:LIF) increases a(MESH:"Transcription Factor AP-1") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:LIF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:STAT3) increases bp(GO:"astrocyte development") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 691f88ac0d
JSON

NF-κB also plays a vital role in axon guidance subsequent to neurogenesis and axon growth in response to neurotrophins, resulting in the integration of the nascent neurons

bp(GO:"axon guidance") increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"axon guidance") increases a(GO:axon) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"axon guidance") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 7ca66ea182
JSON

In addition to CamKII, other kinases activated in response to a rise in cytosolic Ca2+ such as protein kinase C (PKC), phosphatidylinositol-3-kinase (PI3K), and Akt, also activate NF-κB signaling pathway by increasing the phosphorylation and activation of IKK

bp(GO:"calcium ion import") increases act(p(HGNC:CAMK2A)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"calcium ion import") increases act(p(FPLX:PKC)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"calcium ion import") increases act(complex(GO:"phosphatidylinositol 3-kinase complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"calcium ion import") increases act(p(FPLX:AKT)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"IkappaB kinase complex")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"IkappaB kinase complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:AKT)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:AKT)) increases act(complex(GO:"IkappaB kinase complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:AKT)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:PKC)) increases act(complex(GO:"IkappaB kinase complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:PKC)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:CAMK2A)) increases act(complex(GO:"IkappaB kinase complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:CAMK2A)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(MESH:"I-kappa B Kinase", pmod(Ph)) increases act(complex(GO:"IkappaB kinase complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 2b7497b873
JSON

The expression of p65 and p50 is induced in response to long-term changes in synaptic strength and transmission such as LTP [39] and LTD

bp(GO:"long-term synaptic potentiation") decreases p(HGNC:NFKB1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"long-term synaptic depression") decreases p(HGNC:NFKB1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"long-term synaptic depression") decreases p(HGNC:RELA) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

bp(GO:"long-term synaptic potentiation") decreases p(HGNC:RELA) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence ba3d78bf2d
JSON

Moreover, NF-κB – induced IL1 genesis has been shown to precipitate tau phosphorylation at Ser202 and Thr205 (AT8 epitopes) via the activation of the p38- MAPK pathway

bp(GO:"p38MAPK cascade") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases act(p(HGNC:IL1A)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:IL1A)) increases bp(GO:"p38MAPK cascade") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence d483eab787
JSON

The three well characterized sensors of intracellular calcium – calmodulin/CamKII pathway, PI3K/ Akt pathway, and protein kinase C (PKC) pathway – are known to induce NF-κB activation and couple upstream signal transduction pathways that induce calcium dyshomeostasis to NF-κB activation

bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"calcium ion homeostasis") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence c0dc3ecd0a
JSON

This paradoxical incongruity in the effects of NF-κB emanate from the prevailing phosphorylation status of the p65 subunit (Ser536) and coinciding physiological and biochemical stimuli, with the phosphorylation status of p65 being inversely related to the NF-κB – induced neurite outgrowth

bp(MESH:"Neuronal Outgrowth") negativeCorrelation p(HGNC:RELA, pmod(Ph, Ser, 536)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:RELA, pmod(Ph, Ser, 536)) negativeCorrelation bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence c946059e96
JSON

NF-κB acts as a sensor of oxidative stress and it is well established that oxidative stress results in the activation of NF-κB

bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 39613c9473
JSON

The indispensable role of NF-κB in synaptic transmission is corroborated by the fact that the mice that are deficient in neuronal p65, exhibit severe deficits in hippocampal basal synaptic transmission and long term potentiation (LTP)

complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:RELA) increases bp(MESH:"Synaptic Transmission") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HGNC:RELA) increases bp(GO:"long-term synaptic potentiation") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 2046ebd55d
JSON

Given the indispensable role of NF-κB proteins in synaptic transmission and synaptic plasticity, it is not surprising that NF-κB is plays an indispensable role in cognition and behavior as well

complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases bp(GO:"positive regulation of synaptic plasticity") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates bp(GO:cognition) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates bp(GO:behavior) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 907b8ca7b2
JSON

Preponderance of evidence has implicated NF-κB as a survival factor in neurons [24, 114, 115] primarily because of the ability of NF-κB to suppress apoptosis in response to excitotoxic and apoptotic stimuli

complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence e54f8594c1
JSON

Inhibition of NF-κB activity using a κB decoy DNA that results in the sequestration of NF-κB, increases the susceptibility of hippocampal neurons to noxious and apoptotic stimuli

complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

Evidence e5468d58c6
JSON

NF-κB is also indispensable for longterm spatial memory as assessed by radial arm maze [25] and Morris water maze paradigms in mice

complex(GO:"NF-kappaB complex") increases path(MESH:"Spatial Memory") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 3d23064c25
JSON

The molecular mechanisms underlying the aforementioned involvement of NF-κB proteins in learning and memory have not been completely comprehended, although recent evidence has implicated NF-κB – induced transcriptional activation of Protein Kinase A (PKA) catalytic subunit that culminates in activation of CREB (cyclic AMP-response element binding protein) signaling [77] which is regarded as the molecular switch that converts short-term memory to long-term memory

complex(GO:"NF-kappaB complex") increases bp(GO:memory) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases bp(GO:learning) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases act(p(HGNC:PRKACA)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:CREB1)) increases bp(GO:"long-term memory") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:PRKACA)) increases act(p(HGNC:CREB1)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence c6d5d58e01
JSON

This is counter-intuitive as it is established that NF-κB positively regulates the expression of Bcl-XL and other members of the Bcl2 family

complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 11fd2193c9
JSON

The anti-apoptotic effects of NF-κB have been ascribed to its ability to trans-activate the expression of a multitude of anti-apoptotic genes such as Bcl-2, Bcl-XL, and Bfl-1/A1 in the neurons of the amygdala, olfactory bulb, and the CA1/CA3 region of the hippocampus

complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2A1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

p(HGNC:BCL2) decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

p(HGNC:BCL2A1) decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Amygdala
MeSH: CA1 Region, Hippocampal
MeSH: CA3 Region, Hippocampal
MeSH: Olfactory Bulb
MeSH: Alzheimer Disease

Evidence 44bbbdd80a
JSON

NF-κB activity abrogates Amyloid-β peptide-induced toxicity in dissociated hippocampal cultures from C57Bl/6 mice

act(complex(GO:"NF-kappaB complex")) decreases act(a(MESH:"Amyloid beta-Peptides")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 93f3b47876
JSON

The trophic factors that evoke proliferation of NPC by inducing activation of NF-κB include epidermal growth factor (EGF) [155-161], basic fibroblast growth factor (bFGF) [155-161], vascular endothelial growth factor (VEGF) [162], tumor necrosis factor α (TNFα) [163], and erythropoietin (EPO)

act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HGNC:EGF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HGNC:FGF2) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

p(HGNC:VEGFA) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

Evidence 86489d0ea5
JSON

NF-κB also plays a pivotal role in the differentiation of neural stem cells

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"stem cell division") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Neurons
MeSH: Alzheimer Disease

Evidence 2381287769
JSON

IL6 is another NF-κB – induced [256-260] pro-inflammatory cytokine up-regulated and integrally involved in the etio-pathogenesis of Alzheimer’s disease

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:IL6) association path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

path(MESH:"Alzheimer Disease") association p(HGNC:IL6) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 12ee018810
JSON

Furthermore, NF-κB - induced IL6 has been demonstrated to evoke hyperphosphorylation of tau at Ser202 and Thr205 via the activation of the cdk5/p35 complex

complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:IL6) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 044e624141
JSON

NF-κB is also indispensable in the neuronal differentiation of neuroblastoma cells [186] as its transcriptional activity directly orchestrates dendritic spine formation and neurite outgrowth

act(complex(GO:"NF-kappaB complex")) increases bp(GO:"dendritic spine organization") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 802ef00fb1
JSON

Multiple studies have implicated NF-κB in the regulation of post-natal axonal growth or neurite outgrowth.

act(complex(GO:"NF-kappaB complex")) increases a(GO:axon) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence ca9c60e090
JSON

Both, brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) promote neurite outgrowth, in a NF- κB - dependent manner, in primary cultures of nodose ganglion sensory neurons from developing mice

act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:BDNF) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:BDNF) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:CNTF) increases bp(MESH:"Neuronal Outgrowth") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence f07762be33
JSON

NF-κB positively regulates the expression of extracellular matrix protein involved in cell adhesion, β1-integrin [199], a well characterized pivotal player in axon growth initiation and guidance

complex(GO:"NF-kappaB complex") increases p(HGNC:ITGB1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:ITGB1) increases bp(GO:"axon guidance") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:ITGB1) increases a(GO:axon) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 0032b5c692
JSON

Furthermore, NF-κB directly regulates the expression of a plethora of cell adhesion molecules such as neural cell adhesion molecule (NCAM) [202], slit and Trk-like family member 1 (SLITRK1) [203], glial cell-derived neurotrophic factor receptor α1 (GFRα1) [204], and T-lymphoma and metastasis 1 (TLAM1) [203], key players in directing axon growth.

complex(GO:"NF-kappaB complex") regulates p(HGNC:NCAM1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:SLITRK1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:GFRA1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:TIAM1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:GFRA1) increases a(GO:axon) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:NCAM1) increases a(GO:axon) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:SLITRK1) increases a(GO:axon) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:TIAM1) increases a(GO:axon) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence d0059d91d5
JSON

NF-κB is integrally involved in the orchestration of growth of dendritic arbors and critically regulates dendritic morphology because of its indispensable role in dendritic growth and branching

act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Dendritic Cells") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases a(GO:"dendritic branch") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 521c451198
JSON

NF-κB activation directly induces the transcription of Hes1 and Hes5 [206, 207], two key transcription factors involved in the regulation of expression of proteins involved in dendritic growth, morphology, and branching

act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES5) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:HES1) increases a(GO:"dendritic branch") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:HES1) increases a(MESH:"Dendritic Cells") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:HES5) increases a(GO:"dendritic branch") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:HES5) increases a(MESH:"Dendritic Cells") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence aab8436b82
JSON

NF-κB activates the expression of the two microtubule-associated proteins, microtubule-associated protein 1B (MAP1B) and microtubule-associated protein 2 (MAP2) [209], two major proteins known to play a pivotal role in the growth, elongation, and arborization of dendrites

complex(GO:"NF-kappaB complex") increases p(HGNC:MAP1B) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:MAP2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:MAP1B) increases a(MESH:"Dendritic Cells") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:MAP2) increases a(MESH:"Dendritic Cells") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence a3cb009eae
JSON

NF-κB directly regulates the transcription of a multitude of proteins of the complement pathway that are involved in antigen presenting such as C3 (complement component 3) [241], Bf (complement factor B) [242], and CR2 (complement receptor 2) [243] as well as acute phase proteins such as C4 (complement factor 4) [244] and C4BPA (complement factor 4 binding protein)

complex(GO:"NF-kappaB complex") regulates p(HGNC:C3) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:CFB) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:CR2) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:C4A) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:C4BPA) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 1c92f68557
JSON

It is well established that NF-κB is one of the most prominent transcription factors that regulates IL1β production

complex(GO:"NF-kappaB complex") regulates p(HGNC:IL1B) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 1d3536f198
JSON

Another known target of NF-κB, TNFα [266, 267] is also up-regulated in the cortex [268], cerebrospinal fluid, and the serum of Alzheimer’s disease patients

complex(GO:"NF-kappaB complex") regulates p(HGNC:TNF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence f0ba765994
JSON

Multiple studies have cogently shown that the inhibition of NF-κB activity results in the mitigation of secreted Amyloid-β by cultured cells in vitro

act(complex(GO:"NF-kappaB complex")) increases sec(a(CHEBI:"amyloid-beta")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence e4f8fec84d
JSON

NF-κB is also widely implicated in the engenderment of Amyloid-β in vivo in a multitude of mouse models

act(complex(GO:"NF-kappaB complex")) increases a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 0f22dc26f3
JSON

A multitude of studies have demonstrated that NF-κB directly regulates the transcription and expression of BACE1, thereby eliciting profound effects on AβPP processing and engenderment of Amyloid-β

complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates bp(HBP:"APP processing") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 340a04f6f5
JSON

NF-κB induced up-regulation in BACE1 expression is contingent on the nature of the NF-κB heterodimer

complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 66fe8b61d8
JSON

Recent studies have unveiled a novel role of NF-κB in the regulation of the γ-secretase activity mediated processing of the C99 (CTFβ) fragment

complex(GO:"NF-kappaB complex") regulates p(HBP:C99) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates act(complex(GO:"gamma-secretase complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"gamma-secretase complex") regulates p(HBP:C99) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 102fd4230b
JSON

In addition to augmenting γ-secretase activity, NF-κB also regulates the expression of the PS1 subunit of the γ-secretase complex

complex(GO:"NF-kappaB complex") increases act(complex(GO:"gamma-secretase complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(GO:"NF-kappaB complex") regulates p(HGNC:PSEN1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence dc36d6117c
JSON

Furthermore, two κB-binding sites have been identified in the proximal promoter region of AβPP, suggesting the potential regulation of AβPP expression by NF-κB

complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence e1db3791e8
JSON

The binding of p65/p50 or p65/p52 NF- κB heterodimer in the BACE1 promoter results in transcriptional activation whereas the binding of c-Rel/p52 heterodimer results in repression of BACE1 transcription

complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) increases p(HGNC:BACE1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) increases p(HGNC:BACE1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) decreases p(HGNC:BACE1) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(p(HGNC:NFKB1), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(p(HGNC:NFKB2), p(HGNC:REL)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:REL)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

complex(p(HGNC:NFKB2), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 27d8e30615
JSON

p50 knock-out mice exhibit deficits in late LTP resulting in compromised spatial memory

p(HGNC:NFKB1) increases path(MESH:"Spatial Memory") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:NFKB1) increases bp(GO:"long-term synaptic potentiation") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 3d934c912c
JSON

p50 knock-out mice exhibit severe deficits in learning as assessed by an active avoidance assay [93] in addition to displaying lack of anxiety-like behavior in well-established tests and paradigms that assess exploratory drive as a measure of anxiety

p(HGNC:NFKB1) increases bp(GO:learning) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:NFKB1) increases path(MESH:Anxiety) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence fcda95a1e2
JSON

c-Rel null mice exhibit deficits in hippocampal long term depression (LTD), despite the lack of presence of c-Rel at the synapses in wild-type mic

p(HGNC:REL) increases bp(GO:"long-term synaptic depression") View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

Evidence 9107e493e1
JSON

Multiple studies have demonstrated the presence of NF-κB in the synapses and synaptosomal preparations [25, 35, 39] and the presynaptic protein synaptophysin has been shown to co-localize with the p65 and p50 subunits of NF- κB in synaptosomal preparations [25, 35, 39], also been observed in the dendritic spines of the post-synaptic densities of the synaptosomes isolated from the hippocampus and the cerebral cortex

p(HGNC:SYP) increases complex(p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:SYP)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

Evidence 6ee50302f9
JSON

NF-κB induction and activation mediates the neuroprotection bestowed by pre-conditioning with a sub-optimal dose of kainic acid and linolenic acid against severe ischemia

composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Hippocampus
MeSH: Alzheimer Disease

Evidence 2216bc9194
JSON

The mechanism underlying the effect of BDNF and CNTF on NF-κB activation has been attributed to the activation of Src and Lck non-receptor tyrosine kinases which phosphorylate IκBα on Tyr42 resulting in subsequent NF-κB activation

p(HGNC:BDNF) increases act(p(HGNC:SRC)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:CNTF) increases act(p(HGNC:LCK)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:LCK)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

act(p(HGNC:SRC)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) View Subject | View Object

Appears in Networks:

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Annotations

MeSH: Alzheimer Disease

PubMed: 28745240

Evidence a83424e2a1 JSON

a(CHEBI:"amyloid-beta") decreases bp(GO:"calcium ion homeostasis") View Subject | View Object

Appears in Networks:

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a(CHEBI:"amyloid-beta") association bp(MESH:"Oxidative Stress") View Subject | View Object

Appears in Networks:

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bp(GO:"calcium ion homeostasis") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

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bp(MESH:"Oxidative Stress") association a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:

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bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

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Evidence 1a67733ba7 JSON

a(CHEBI:"amyloid-beta") increases bp(MESH:"Oxidative Stress") View Subject | View Object

Appears in Networks:

Annotations

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Annotations

bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Annotations

Evidence 63de27867f JSON

a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

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a(CHEBI:"amyloid-beta") increases bp(GO:"JNK cascade") View Subject | View Object

Appears in Networks:

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a(CHEBI:"amyloid-beta") increases bp(GO:"Fas signaling pathway") View Subject | View Object

Appears in Networks:

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bp(GO:"Fas signaling pathway") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

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bp(GO:"Fas signaling pathway") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

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bp(GO:"JNK cascade") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

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bp(GO:"JNK cascade") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Annotations

Evidence 82a4b4fd82 JSON

a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") View Subject | View Object

Appears in Networks:

Annotations

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

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a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1) View Subject | View Object

Appears in Networks:

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a(CHEBI:"amyloid-beta") decreases sec(a(PUBCHEM:16057918)) View Subject | View Object

Appears in Networks:

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complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1) View Subject | View Object

Appears in Networks:

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complex(GO:"NF-kappaB complex") decreases sec(a(PUBCHEM:16057918)) View Subject | View Object

Appears in Networks:

Annotations

p(HGNC:BCL2L1) increases sec(a(PUBCHEM:16057918)) View Subject | View Object

Appears in Networks:

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Evidence dff983455b JSON

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Annotations

a(CHEBI:"amyloid-beta") increases complex(a(GO:"membrane attack complex"), p(HGNC:C5)) View Subject | View Object

Appears in Networks:

Annotations

complex(a(GO:"membrane attack complex"), p(HGNC:C5)) increases act(complex(GO:"NF-kappaB complex")) View Subject | View Object

Appears in Networks:

Evidence a83424e2a1
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Evidence 1a67733ba7
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Evidence 63de27867f
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Evidence 82a4b4fd82
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Evidence dff983455b
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Evidence 74758c68b9
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Evidence 086cc4b387
JSON

Evidence 47a27ac8b1
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Evidence f1f8fb0c4f
JSON

Evidence 8e97bc74ff
JSON

Evidence 6a6e176353
JSON

Evidence 20cec60ea3
JSON