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complex(p(HGNC:NFKB1), p(HGNC:RELA))

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Components

Appears in Networks 2

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0

In-Edges 3

a(GO:synapse) association complex(p(HGNC:NFKB1), p(HGNC:RELA)) View Subject | View Object

Other species of NF-κB have not been found at the synapses suggesting that the synapses contain the p65-p50 heterodimer exclusively PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"amyloid-beta polypeptide 42") increases complex(p(HGNC:NFKB1), p(HGNC:RELA)) View Subject | View Object

Exposure of primary neuronal cells or post-mitotic neurons to Aβ1-42 peptide has been shown to strongly activate the p50:p65 dimers and mediate neuronal cell death (Fig 1) PubMed:25652642

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Alzheimer Disease

a(CHEBI:"glutamate(1-)") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) View Subject | View Object

Glutamate induced stimulation of cerebellar granule cells via the N-methyl-D-aspartate (NMDA) receptor activate p65:p50 dimers and enhance transactivation of pro-apoptotic factors PubMed:25652642

Appears in Networks:

Out-Edges 5

complex(p(HGNC:NFKB1), p(HGNC:RELA)) hasComponent p(HGNC:NFKB1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:NFKB1), p(HGNC:RELA)) hasComponent p(HGNC:RELA) View Subject | View Object

Appears in Networks:

complex(p(HGNC:NFKB1), p(HGNC:RELA)) association a(GO:synapse) View Subject | View Object

Other species of NF-κB have not been found at the synapses suggesting that the synapses contain the p65-p50 heterodimer exclusively PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

complex(p(HGNC:NFKB1), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) View Subject | View Object

The binding of p65/p50 or p65/p52 NF- κB heterodimer in the BACE1 promoter results in transcriptional activation whereas the binding of c-Rel/p52 heterodimer results in repression of BACE1 transcription PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) increases bp(GO:"apoptotic process") View Subject | View Object

Glutamate induced stimulation of cerebellar granule cells via the N-methyl-D-aspartate (NMDA) receptor activate p65:p50 dimers and enhance transactivation of pro-apoptotic factors PubMed:25652642

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.