path(HBP:Excitotoxicity) increases bp(GO:"neuron death")

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PubMed:28745240

Consequently, NF-κB is constitutively activated in the excitatory neurons of the cerebral cortex (layers 2, 4, and 5), hippocampus (granule and pyramidal neurons of CA1 and CA3), and cerebellar granule cells and this constitutive activity is indispensable for neuronal survival in response to glutamate-induced excitotoxicity

Related Edges 2

• act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex"))
• act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death")

MeSH

Alzheimer Disease

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