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bp(GO:"p38MAPK cascade")

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Entity

Name
p38MAPK cascade
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

In-Edges 3

a(CHEBI:nicotine) increases bp(GO:"p38MAPK cascade") View Subject | View Object

The possible mechanism by which nicotine enhances the aggregation of tau is through the activation of p38-MAP kinase PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade") View Subject | View Object

Additionally, it can induce phosphorylation of the tau protein and promote for- mation of neurofibrillary tangles through the mitogen activated protein kinases-p38 (MAPK-p38) stress pathway [22, 54]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
MAPK-JNK subgraph
NeuroMMSigDB
Nitric oxide subgraph
NeuroMMSigDB
Tau protein subgraph

act(p(HGNC:IL1A)) increases bp(GO:"p38MAPK cascade") View Subject | View Object

Moreover, NF-κB – induced IL1 genesis has been shown to precipitate tau phosphorylation at Ser202 and Thr205 (AT8 epitopes) via the activation of the p38- MAPK pathway PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 3

bp(GO:"p38MAPK cascade") increases a(HBP:"Tau aggregates") View Subject | View Object

The possible mechanism by which nicotine enhances the aggregation of tau is through the activation of p38-MAP kinase PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle") View Subject | View Object

Additionally, it can induce phosphorylation of the tau protein and promote for- mation of neurofibrillary tangles through the mitogen activated protein kinases-p38 (MAPK-p38) stress pathway [22, 54]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease
NeuroMMSigDB
MAPK-JNK subgraph
NeuroMMSigDB
Nitric oxide subgraph
NeuroMMSigDB
Tau protein subgraph

bp(GO:"p38MAPK cascade") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) View Subject | View Object

Moreover, NF-κB – induced IL1 genesis has been shown to precipitate tau phosphorylation at Ser202 and Thr205 (AT8 epitopes) via the activation of the p38- MAPK pathway PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.