act(p(FPLX:AKT)) increases p(MESH:"I-kappa B Kinase", pmod(Ph))

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PubMed:28745240

In addition to CamKII, other kinases activated in response to a rise in cytosolic Ca2+ such as protein kinase C (PKC), phosphatidylinositol-3-kinase (PI3K), and Akt, also activate NF-κB signaling pathway by increasing the phosphorylation and activation of IKK

Related Edges 16

• bp(GO:"calcium ion import") increases act(p(HGNC:CAMK2A))
• bp(GO:"calcium ion import") increases act(p(FPLX:PKC))
• bp(GO:"calcium ion import") increases act(complex(GO:"phosphatidylinositol 3-kinase complex"))
• bp(GO:"calcium ion import") increases act(p(FPLX:AKT))
• act(complex(GO:"IkappaB kinase complex")) increases act(complex(GO:"NF-kappaB complex"))
• act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"NF-kappaB complex"))
• act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"IkappaB kinase complex"))
• act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases p(MESH:"I-kappa B Kinase", pmod(Ph))
• act(p(FPLX:AKT)) increases act(complex(GO:"NF-kappaB complex"))
• act(p(FPLX:AKT)) increases act(complex(GO:"IkappaB kinase complex"))
• act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex"))
• act(p(FPLX:PKC)) increases act(complex(GO:"IkappaB kinase complex"))
• act(p(FPLX:PKC)) increases p(MESH:"I-kappa B Kinase", pmod(Ph))
• act(p(HGNC:CAMK2A)) increases act(complex(GO:"IkappaB kinase complex"))
• act(p(HGNC:CAMK2A)) increases p(MESH:"I-kappa B Kinase", pmod(Ph))
• p(MESH:"I-kappa B Kinase", pmod(Ph)) increases act(complex(GO:"IkappaB kinase complex"))

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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