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p(HGNC:CREB1)

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Entity

Name
CREB1
Namespace
hgnc
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/hgnc-symbols.belns

Appears in Networks 4

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0

The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation* v1.0.0

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0

In-Edges 2

tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) increases act(p(HGNC:CREB1), ma(tscript)) View Subject | View Object

Additionally, SNARE-dependent trafficking was required for α7 AChRs to be capable of activating the transcription factor cAMP response element-binding protein and attendant gene ex- pression when challenged. PubMed:22040696

Appears in Networks:

act(p(HGNC:PRKACA)) increases act(p(HGNC:CREB1)) View Subject | View Object

The molecular mechanisms underlying the aforementioned involvement of NF-κB proteins in learning and memory have not been completely comprehended, although recent evidence has implicated NF-κB – induced transcriptional activation of Protein Kinase A (PKA) catalytic subunit that culminates in activation of CREB (cyclic AMP-response element binding protein) signaling [77] which is regarded as the molecular switch that converts short-term memory to long-term memory PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 2

p(HGNC:CREB1) hasVariant p(HGNC:CREB1, pmod(Ph)) View Subject | View Object

Appears in Networks:

act(p(HGNC:CREB1)) increases bp(GO:"long-term memory") View Subject | View Object

The molecular mechanisms underlying the aforementioned involvement of NF-κB proteins in learning and memory have not been completely comprehended, although recent evidence has implicated NF-κB – induced transcriptional activation of Protein Kinase A (PKA) catalytic subunit that culminates in activation of CREB (cyclic AMP-response element binding protein) signaling [77] which is regarded as the molecular switch that converts short-term memory to long-term memory PubMed:28745240

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.