1. Catalog
  2. Nodes
  3. a(MESH:"Reactive Oxygen Species")

a(MESH:"Reactive Oxygen Species")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Reactive Oxygen Species
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 48

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Heme activates neutrophils and endothelial cells, by ROS generation. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(CHEBI:"iron(2+)") increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

ROS generation by haem is at least partially dependent on the Fenton reaction, in which iron catalyses the production of toxic ROS (Wagener et al, 2003). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:"3-nitrotyrosine") positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Protein tyrosine nitration has been identified as a biomarker of oxidative stress, and the generation of 3-nitrotyrosine (3-NT) is often accompanied with the increasing of ROS and RNS under pathologic condition [14]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

a(CHEBI:"alpha-tocopherol") decreases a(MESH:"Reactive Oxygen Species") View Subject | View Object

As expected, α-tocopherol treatment prevented ROS accumulation and the induction of anti-oxidant genes in the heart (Figure 6A, B and see Figure 8 in [37]). PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Results

a(CHEBI:"iron(2+)") increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

We confirmed that the redox active iron, which is derived from heme catabolism in macrophages, is capable of catalyzing ROS formation (Fig. 7A) (19). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:acetylcysteine) negativeCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

We showed that NAC treatment scavenged ROS production and, more importantly, it counteracted ferroportin induction by heme (Fig. 8B, C). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:dibenziodolium) decreases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Corroborating recent studies that showed heme as an inductor of ROS generation via NADPHox in neutrophils, macrophages and in VSMC [7,8,19], the pretreatment of cells with DPI (10 mM), a NADPHox inhibitor [20], prevented heme-induced ROS production in A7r5 VSMC (Fig. 2A). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Accordingly, Fig. 2A shows that heme (10 mM) induces a strong ROS production after 1 h of incubation with VSMC. PubMed:22954673

Appears in Networks:
Annotations
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Corroborating recent studies that showed heme as an inductor of ROS generation via NADPHox in neutrophils, macrophages and in VSMC [7,8,19], the pretreatment of cells with DPI (10 mM), a NADPHox inhibitor [20], prevented heme-induced ROS production in A7r5 VSMC (Fig. 2A). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Furthermore, heme induces ROS generation dependent on enzymatic reactions. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Heme induces ROS generation independently of TLR4. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
leukocyte
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(CHEBI:heme) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

The main mediator of these adverse effects is thought to be free haem via its effects on NO scavenging, pro-inflammatory cytokine responses, and reactive oxygen species (ROS) generation. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

In addition, we observed increased ROS production ( Figure 2I; supplemental Figure 2), as well as an enhanced expression of IL-6 and TNFα in cells treated with heme-albumin compared with heme-Hx (Figure 2J-K). PubMed:26675351

Appears in Networks:
Annotations
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

a(CHEBI:heme) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Toxicity of free hemoglobin is also caused by the release of cell-free heme, which produces lipid peroxidation and mitochondrial damage and increases the production of reactive oxygen species. PubMed:27515135

Appears in Networks:
Annotations
Text Location
Introduction

a(CHEBI:heme) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Heme is an amphipathic molecule that can promote the generation of reactive oxygen species (ROS) via Fenton chemistry, thereby leading to membrane damage. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
Text Location
Introduction

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Free heme upregulates heme oxygenase activity, generates reactive oxygen species, and activates endothelial cells and macrophages directly[65]. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:heme) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

As expected, incubation of neutrophils with hemin resulted in a significant number of cells producing ROS (Fig. 8A and B). PubMed:28716864

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
Text Location
Results

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

For instance, earlier studies have demonstrated that neutrophil elastase degrades the hemoglobin liberating free hemin that induces ROS production. PubMed:28716864

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Serum
MeSH
Malaria
Text Location
Discussion

a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

We show that heme, in a concentration range found during hemolytic episodes, increases intracellular ROS production and consequentially signals for ferroportin induction and subsequent iron export from the macrophages. PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Discussion

a(CHEBI:protoporphyrin) causesNoChange a(MESH:"Reactive Oxygen Species") View Subject | View Object

By contrast, treatment of macrophages with PPIX failed to increase the ROS production and ferroportin expression, implying that iron within the heme moiety was required for the observed effects (Fig. 7B). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(MESH:"Mitogen-Activated Protein Kinases") positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Phospholipase C beta") positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Protein Kinase C") positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:Cytokines) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Furthermore, cytokine secretion depends on the coordinated iron in the porphyrin ring (Figueiredo et al, 2007), and nuclear factor-jB (NF-jB), MAPKs activation and ROS are essential for the increase in cytokine production induced by haem (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:Neutrophils) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Although neutrophils have important functions controlling infection, these cells can promote vascular and tissue injury by generating ROS, secreting proteases, and releasing extracellular chromatin (NETs; reviewed in Mócsai, 2013). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

bp(GO:"inflammatory response") positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

As a part of the inflammatory response after injury, oxidative stress due to formation of reactive oxygen species (ROS) is involved both in direct damage of cartilage components and as integral factors in cell signaling leading to cartilage degradation (Henrotin et al., 2003). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

bp(MESH:"Erythrocyte Deformability") negativeCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

bp(MESH:Apoptosis) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Apoptosis has been found to be a major rout for the elimination of cells after a variety of stresses including ROS and RNS [30]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

complex(a(CHEBI:"iron(2+)"), a(CHEBI:heme), a(MESH:"Reactive Oxygen Species")) hasComponent a(MESH:"Reactive Oxygen Species") View Subject | View Object

Appears in Networks:

p(HGNC:HPX) decreases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Taken together, these data demonstrate that Hx limits macrophage heme overload and prevents the prooxidant and proinflammatory effects triggered by heme in cellular assays and in vivo. PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

p(MGI:Hpx) negativeCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Importantly, by scavenging free heme, Hx prevents heme-induced M1 macrophage polarization and thus avoids both TLR4 activation and ROS formation. PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Discussion

p(MGI:Hpx) decreases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Being heme a well-known pro-oxidant agent [17], we then evaluated ROS levels in CMs exposed to heme alone or bound to either Hx or albumin. In the presence of Hx-heme complexes, CMs were protected from ROS formation, if compared to CMs treated with either albumin-heme complexes or heme alone (Figure 1D). PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Results

p(HGNC:SERPINA1) decreases a(MESH:"Reactive Oxygen Species") View Subject | View Object

The ability of hemin to trigger ROS production in neutrophils was abrogated significantly in the presence of A1AT (Fig. 8). PubMed:28716864

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
Text Location
Results

complex(a(MESH:"Reactive Oxygen Species"), p(HGNC:HBB)) hasComponent a(MESH:"Reactive Oxygen Species") View Subject | View Object

Appears in Networks:

p(HGNC:MAPK8) increases a(MESH:"Reactive Oxygen Species") View Subject | View Object

WhileMAPK8 increases ROS generation, TNF induces RIP1–RIP3 necrosome which triggers necroptosis. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
leukocyte
MeSH
Liver
MeSH
Malaria
Text Location
Review

p(MGI:Prdx2) negativeCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23]. PubMed:24489717

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:AMBP) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

act(p(HGNC:PDPK1)) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

p(HGNC:ROCK1) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

act(p(PFAM:"CaMKII_AD")) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Mechanistically, heme-derived ROS may directly modify Ca2+ handling proteins (such as the RyR2 or SERCA2a) [35, 57], and may also activate intracellular stress kinases, such as CaMKII [58], which in turn phosphorylate the same Ca2+ effectors and ultimately exacerbate Ca2+ mishandling. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Discussion

p(RGD:Hmox1) decreases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Additionally, it was observed that inhibition of HO-1 by ZnPP induced a further increase in hemeinduced ROS production (Fig. 4C), suggesting that activation of HO system attenuates the NADPHox-dependent activation of VSMC induced by heme. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

path(MESH:"Heart Failure") positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Excess production of reactive oxygen species (ROS) has been implicated in progression of chronic heart failure as well as in other cardiovascular disorders including ischemia-reperfusion injury and cardiovascular complications of hemolytic diseases [2-7]. PubMed:28400318

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:"Reperfusion Injury") positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Excess production of reactive oxygen species (ROS) has been implicated in progression of chronic heart failure as well as in other cardiovascular disorders including ischemia-reperfusion injury and cardiovascular complications of hemolytic diseases [2-7]. PubMed:28400318

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Atherosclerosis) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
smooth muscle cell
Text Location
Introduction

path(MESH:Hypertension) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
smooth muscle cell
Text Location
Introduction

rxn(reactants(p(HGNC:HBB)), products(a(CHEBI:methemoglobin))) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

. In the presence of reactive oxygen species (ROS), Hb is oxidized to methemoglobin (MetHb; Balla et al., 1993), characterized by the change in the oxidative state of the Fe present in the heme molecule from ferrous (Fe+2) to ferric (Fe+3). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 38

a(MESH:"Reactive Oxygen Species") increases bp(GO:"endothelial cell activation") View Subject | View Object

Heme activates neutrophils and endothelial cells, by ROS generation. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(MESH:"Reactive Oxygen Species") negativeCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

a(MESH:"Reactive Oxygen Species") negativeCorrelation p(MGI:Prdx2) View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

a(MESH:"Reactive Oxygen Species") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23]. PubMed:24489717

Appears in Networks:
Annotations
Text Location
Introduction

a(MESH:"Reactive Oxygen Species") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

a(MESH:"Reactive Oxygen Species") positiveCorrelation rxn(reactants(p(HGNC:HBB)), products(a(CHEBI:methemoglobin))) View Subject | View Object

. In the presence of reactive oxygen species (ROS), Hb is oxidized to methemoglobin (MetHb; Balla et al., 1993), characterized by the change in the oxidative state of the Fe present in the heme molecule from ferrous (Fe+2) to ferric (Fe+3). PubMed:24904418

Appears in Networks:
Annotations
Text Location
Review

a(MESH:"Reactive Oxygen Species") increases bp(GO:"neutrophil migration") View Subject | View Object

A seminal study demonstrated that the ability of heme to activate neutrophils depend on protein kinase C (PKC) activation and ROS generation, inducing the expression of adhesion molecules and modifying actin cytoskeleton dynamics, necessary features for neutrophils migration (Graça-Souza et al., 2002). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(MESH:Neutrophils) View Subject | View Object

Although neutrophils have important functions controlling infection, these cells can promote vascular and tissue injury by generating ROS, secreting proteases, and releasing extracellular chromatin (NETs; reviewed in Mócsai, 2013). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(MESH:"Reactive Oxygen Species") increases p(HGNC:TNF) View Subject | View Object

However, ROS is necessary to induce TNF secretion and MAPK activation. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
leukocyte
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(MESH:"Reactive Oxygen Species") increases complex(p(HGNC:MAPK1), p(HGNC:MAPK14), p(HGNC:MAPK8)) View Subject | View Object

However, ROS is necessary to induce TNF secretion and MAPK activation. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
leukocyte
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(MESH:"Reactive Oxygen Species") increases bp(MESH:"Neutrophil Activation") View Subject | View Object

Heme activates neutrophils and endothelial cells, by ROS generation. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(CHEBI:heme) View Subject | View Object

The main mediator of these adverse effects is thought to be free haem via its effects on NO scavenging, pro-inflammatory cytokine responses, and reactive oxygen species (ROS) generation. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Toxicity of free hemoglobin is also caused by the release of cell-free heme, which produces lipid peroxidation and mitochondrial damage and increases the production of reactive oxygen species. PubMed:27515135

Appears in Networks:
Annotations
Text Location
Introduction

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Heme is an amphipathic molecule that can promote the generation of reactive oxygen species (ROS) via Fenton chemistry, thereby leading to membrane damage. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(CHEBI:heme) View Subject | View Object

As expected, incubation of neutrophils with hemin resulted in a significant number of cells producing ROS (Fig. 8A and B). PubMed:28716864

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
Text Location
Results

a(MESH:"Reactive Oxygen Species") increases bp(MESH:"Cytotoxicity, Immunologic") View Subject | View Object

These ROS then oxidize cell membrane constituents to induce cytotoxicity and promote inflammation and thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") increases path(MESH:Inflammation) View Subject | View Object

These ROS then oxidize cell membrane constituents to induce cytotoxicity and promote inflammation and thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") increases path(MESH:Thrombosis) View Subject | View Object

These ROS then oxidize cell membrane constituents to induce cytotoxicity and promote inflammation and thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation act(p(HGNC:PDPK1)) View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(MESH:"Phospholipase C beta") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(MESH:"Protein Kinase C") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(MESH:"Mitogen-Activated Protein Kinases") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation p(HGNC:ROCK1) View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(MESH:Cytokines) View Subject | View Object

Furthermore, cytokine secretion depends on the coordinated iron in the porphyrin ring (Figueiredo et al, 2007), and nuclear factor-jB (NF-jB), MAPKs activation and ROS are essential for the increase in cytokine production induced by haem (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") increases bp(MESH:"Platelet Activation") View Subject | View Object

Platelets may be activated during haemolysis by several different mechanisms involving decreased NO levels, increased pro-inflammatory cytokines and mediators, and ROS. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") negativeCorrelation p(MGI:Hpx) View Subject | View Object

Importantly, by scavenging free heme, Hx prevents heme-induced M1 macrophage polarization and thus avoids both TLR4 activation and ROS formation. PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Discussion

a(MESH:"Reactive Oxygen Species") positiveCorrelation path(MESH:"Heart Failure") View Subject | View Object

Excess production of reactive oxygen species (ROS) has been implicated in progression of chronic heart failure as well as in other cardiovascular disorders including ischemia-reperfusion injury and cardiovascular complications of hemolytic diseases [2-7]. PubMed:28400318

Appears in Networks:
Annotations
Text Location
Introduction

a(MESH:"Reactive Oxygen Species") positiveCorrelation path(MESH:"Reperfusion Injury") View Subject | View Object

Excess production of reactive oxygen species (ROS) has been implicated in progression of chronic heart failure as well as in other cardiovascular disorders including ischemia-reperfusion injury and cardiovascular complications of hemolytic diseases [2-7]. PubMed:28400318

Appears in Networks:
Annotations
Text Location
Introduction

a(MESH:"Reactive Oxygen Species") increases bp(MESH:"Cell Proliferation") View Subject | View Object

Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
smooth muscle cell
Text Location
Introduction

a(MESH:"Reactive Oxygen Species") positiveCorrelation path(MESH:Atherosclerosis) View Subject | View Object

Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
smooth muscle cell
Text Location
Introduction

a(MESH:"Reactive Oxygen Species") positiveCorrelation path(MESH:Hypertension) View Subject | View Object

Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
smooth muscle cell
Text Location
Introduction

a(MESH:"Reactive Oxygen Species") positiveCorrelation act(p(PFAM:"CaMKII_AD")) View Subject | View Object

Mechanistically, heme-derived ROS may directly modify Ca2+ handling proteins (such as the RyR2 or SERCA2a) [35, 57], and may also activate intracellular stress kinases, such as CaMKII [58], which in turn phosphorylate the same Ca2+ effectors and ultimately exacerbate Ca2+ mishandling. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
regular cardiac myocyte
Text Location
Discussion

a(MESH:"Reactive Oxygen Species") negativeCorrelation a(CHEBI:acetylcysteine) View Subject | View Object

We showed that NAC treatment scavenged ROS production and, more importantly, it counteracted ferroportin induction by heme (Fig. 8B, C). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(MESH:"Reactive Oxygen Species") increases p(MGI:Slc40a1) View Subject | View Object

We show that heme, in a concentration range found during hemolytic episodes, increases intracellular ROS production and consequentially signals for ferroportin induction and subsequent iron export from the macrophages. PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Discussion

a(MESH:"Reactive Oxygen Species") positiveCorrelation bp(MESH:Apoptosis) View Subject | View Object

Apoptosis has been found to be a major rout for the elimination of cells after a variety of stresses including ROS and RNS [30]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(CHEBI:"3-nitrotyrosine") View Subject | View Object

Protein tyrosine nitration has been identified as a biomarker of oxidative stress, and the generation of 3-nitrotyrosine (3-NT) is often accompanied with the increasing of ROS and RNS under pathologic condition [14]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

a(MESH:"Reactive Oxygen Species") positiveCorrelation bp(GO:"inflammatory response") View Subject | View Object

As a part of the inflammatory response after injury, oxidative stress due to formation of reactive oxygen species (ROS) is involved both in direct damage of cartilage components and as integral factors in cell signaling leading to cartilage degradation (Henrotin et al., 2003). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

a(MESH:"Reactive Oxygen Species") increases bp(MESH:"Oxidative Stress") View Subject | View Object

As a part of the inflammatory response after injury, oxidative stress due to formation of reactive oxygen species (ROS) is involved both in direct damage of cartilage components and as integral factors in cell signaling leading to cartilage degradation (Henrotin et al., 2003). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.