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bp(GO:"neutrophil migration")

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Entity

Name
neutrophil migration
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 9

a(CHEBI:"leukotriene B4") increases bp(GO:"neutrophil migration") View Subject | View Object

In fact, heme can induce neutrophil migration by acting as a chemotactic molecule (Porto et al., 2007) or by inducing the production of leukotriene B4 (LTB4) by macrophages (Monteiro et al., 2011). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(CHEBI:"leukotriene B4") increases bp(GO:"neutrophil migration") View Subject | View Object

As described before, LTB4 has an important function regulating heme-induced neutrophils migration (Monteiro et al., 2011). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(CHEBI:heme) increases bp(GO:"neutrophil migration") View Subject | View Object

Heme activates endothelial cells inducing the expression of the adhesion molecules ICAM-1 (intercellular adhesion molecule 1), VCAM-1 (vascular cell adhesion molecule 1), E-selectin, Pselectin, and von Willebrand factor (VWF; Wagener et al., 1997; Belcher et al., 2014) and causes neutrophil migration (GraçaSouza et al., 2002; Porto et al., 2007). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(CHEBI:heme) increases bp(GO:"neutrophil migration") View Subject | View Object

A seminal study demonstrated that the ability of heme to activate neutrophils depend on protein kinase C (PKC) activation and ROS generation, inducing the expression of adhesion molecules and modifying actin cytoskeleton dynamics, necessary features for neutrophils migration (Graça-Souza et al., 2002). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(CHEBI:heme) increases bp(GO:"neutrophil migration") View Subject | View Object

As described before, LTB4 has an important function regulating heme-induced neutrophils migration (Monteiro et al., 2011). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(CHEBI:heme) increases bp(GO:"neutrophil migration") View Subject | View Object

With the triggering of the oxidative burst and modification of actin cytoskeleton dynamics, hemin also induces neutrophil migration [10] PubMed:28716864

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
Text Location
Introduction

a(MESH:"Protein Kinase C") increases bp(GO:"neutrophil migration") View Subject | View Object

A seminal study demonstrated that the ability of heme to activate neutrophils depend on protein kinase C (PKC) activation and ROS generation, inducing the expression of adhesion molecules and modifying actin cytoskeleton dynamics, necessary features for neutrophils migration (Graça-Souza et al., 2002). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(MESH:"Reactive Oxygen Species") increases bp(GO:"neutrophil migration") View Subject | View Object

A seminal study demonstrated that the ability of heme to activate neutrophils depend on protein kinase C (PKC) activation and ROS generation, inducing the expression of adhesion molecules and modifying actin cytoskeleton dynamics, necessary features for neutrophils migration (Graça-Souza et al., 2002). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

p(HGNC:SERPINA1) decreases bp(GO:"neutrophil migration") View Subject | View Object

Under the same experimental conditions, addition of 1 mg/ ml A1AT significantly prevented hemin-induced neutrophil spreading and adhesion (Fig. 3A). PubMed:28716864

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
Text Location
Results

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.