The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0||28%|
|Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-b peptide and s levels: target engagement, tolerability and pharmacokinetics in humans v0.1.0||27%|
|Tau protein aggregation is associated with cellular senescence in the brain v1.0.0||22%|
|Inﬂammasome Involvement in Alzheimer’s Disease v1.0.0||22%|
|The role of inflammasome in Alzheimer’s disease v1.0.3||21%|
|Amelioration of Experimental Autoimmune Encephalomyelitis by Anatabine v1.0.0||21%|
|Molecular chaperones and proteostasis regulation during redox imbalance v1.0.0||20%|
|In Vivo and In Vitro Characterization of Antalarmin, a Nonpeptide Corticotropin-Releasing Hormone (CRH) Receptor Antagonist: Suppression of Pituitary ACTH Release and Peripheral Inflammation v1.0.0||20%|
|Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis v1.0.0||18%|
|Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2||17%|
As such, it nitrosylates the haem-moiety of guanylate cyclase, thereby stimulating formation of cyclic guanine monophosphate (cGMP), which then initiates calcium-dependent vasodilation (Olson et al, 2004).
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.