The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|BEL Framework Large Corpus Document v20170611||54%|
|Mast cell activation-2.0-Hs v2.0||41%|
|Mast cell activation-2.0-Mm v2.0||41%|
|Epithelial Innate Immune Activation-2.0-Rn v2.0||33%|
|Selventa Protein Families Definitions v20150611||28%|
|B-cell Signaling-2.0-Rn v2.0||26%|
|Epithelial Mucus Hypersecretion-2.0-Rn v2.0||20%|
|Immune Regulation of Tissue Repair-2.0-Rn v2.0||20%|
|Neutrophil Signaling-2.0-Rn v2.0||20%|
|Th1-Th2 Signaling-2.0-Rn v2.0||20%|
Here we demonstrate that functional uncoupling between CD38 and Cx43 in CD38-transfected 3T3 murine fibroblasts is paralleled by decreased [Ca(2+)](i) levels as a result of reduced intracellular conversion of NAD(+) to cADPR
In results, read the section "cAMP signalling attenuates CSE-induced IL-8 release from human ASM cells": "The CSE-induced IL-8 release was almost fully inhibited by co-treatment with the β2-agonist fenoterol (0.1 and 1 µM; P<0.001 both; Fig. 1A)..."
As shown in Table I⇓, endogenous sPLA2 induced an increase in cPLA2 activity in BMMC. Furthermore, endogenous sPLA2 released AA from BMMC (Table I⇓). In contrast, levels of other unsaturated fatty acids (LA and OA) were not influenced when BMMC were incubated with partially purified endogenous sPLA2 (Table I⇓).
ANG II has been shown to phosphorylate and activate PLA2, which leads to production of arachidonic acid (AA) and its metabolites. The derivatives of AA function in maintaining vascular tone and in VSMC NAD(P)H oxidation (63). The cyclooxygenase-derived prostaglandins, such as PGI2 and PGE2 are vasodilatory, and are counteracted by PGH2 and thromboxane A2, which promote vasoconstriction.
Moreover, coupling of heterotrimeric G proteins containing G alpha i3 C S to the m2 mAChR resulted in pertussis toxin-resistant inhibition of adenylyl cyclase, stimulation of phospholipase C-induced intracellular Ca2+ release, and phospholipase A2-mediated arachidonic acid release. Therefore, these studies provide conclusive evidence that heterotrimeric G proteins containing just G alpha i3 can regulate multiple effector enzymes within the same cell type.
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