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a(MESH:"Protein Kinase C")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Protein Kinase C
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

a(MESH:"Reactive Oxygen Species") positiveCorrelation a(MESH:"Protein Kinase C") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

Out-Edges 3

a(MESH:"Protein Kinase C") increases bp(GO:"neutrophil migration") View Subject | View Object

A seminal study demonstrated that the ability of heme to activate neutrophils depend on protein kinase C (PKC) activation and ROS generation, inducing the expression of adhesion molecules and modifying actin cytoskeleton dynamics, necessary features for neutrophils migration (Graça-Souza et al., 2002). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(MESH:"Protein Kinase C") positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Furthermore, ROS induction by haem directly depends on signal transduction involving Ga inhibitory protein and phosphoinositide 3-kinase, and partially depends on phospholipase Cb, protein kinase C, the mitogen-activated protein kinases (MAPKs) and Rho kinase in neutrophils (Porto et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Protein Kinase C") increases act(a(MESH:"NADPH Oxidase")) View Subject | View Object

Inhibiting NADPH oxidase, its upstream activator protein kinase C or antioxidants inhibit haem-mediated stasis, Weibel-Palade body degranulation and oxidant production by the endothelium (Belcher et al, 2014). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.