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bp(MESH:Apoptosis)

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Entity

Name
Apoptosis
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 2

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 12

a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis) View Subject | View Object

The cytoplasmic in- crease in calcium triggers the secretion of mitogenic factors and activates the signalling cascades involved in cell prolif- eration, migration and angiogenesis and the inhibition of apoptosis PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Acetylcholine) association bp(MESH:Apoptosis) View Subject | View Object

but ACh is also released by non-neuronal tissues where it is involved in cell-to-cell communication, and con- trols essential functions such as cell proliferation, adhesion, migration, secretion, survival and apoptosis, in an autocrine, paracrine or juxtacrine manner PubMed:28901280

Appears in Networks:

a(CHEBI:heme) increases bp(MESH:Apoptosis) View Subject | View Object

Moreover, heme induces apoptosis in human brain vascular endothelial cells (HBVEC) by STAT3 (signal transducer and activator of transcription 3)-dependent activation of matrix metallopeptidase 3 (MMP3; Liu et al., 2013). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

a(MESH:"Reactive Nitrogen Species") positiveCorrelation bp(MESH:Apoptosis) View Subject | View Object

Apoptosis has been found to be a major rout for the elimination of cells after a variety of stresses including ROS and RNS [30]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

a(MESH:"Reactive Oxygen Species") positiveCorrelation bp(MESH:Apoptosis) View Subject | View Object

Apoptosis has been found to be a major rout for the elimination of cells after a variety of stresses including ROS and RNS [30]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) positiveCorrelation bp(MESH:Apoptosis) View Subject | View Object

Figure 3a depicts the morphology of SHSY5Y cells after treated with various conditions. Compared with heme/H2O2 treatment, cells exposing to heme/ H2O2/NO2 − exacerbated cell apoptotic and reduced cell yield. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) positiveCorrelation bp(MESH:Apoptosis) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

p(HGNC:ALB) negativeCorrelation bp(MESH:Apoptosis) View Subject | View Object

However, pretreatment with 2 μM BSA or BSA-T, we found that both BSA and BSA-T efficiently inhibited heme/H2O2/NO2 −- induced cell apoptotic and increased cell yields. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

p(HGNC:ALB) negativeCorrelation bp(MESH:Apoptosis) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

p(MGI:Hpx) negativeCorrelation bp(MESH:Apoptosis) View Subject | View Object

In conclusion, an Hx-based therapy shows beneficial effects, in that it counteracts heme-induced proinflammatory activation of macrophages and attenuates some of its pathophysiologic consequences, such as chronic inflammation, hepatic fibrosis, and apoptosis (Figure 7E). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

p(HGNC:ALB, pmod(Ph, Tyr)) negativeCorrelation bp(MESH:Apoptosis) View Subject | View Object

However, pretreatment with 2 μM BSA or BSA-T, we found that both BSA and BSA-T efficiently inhibited heme/H2O2/NO2 −- induced cell apoptotic and increased cell yields. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

p(HGNC:ALB, pmod(Ph, Tyr)) negativeCorrelation bp(MESH:Apoptosis) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

Out-Edges 11

bp(MESH:Apoptosis) association a(MESH:Acetylcholine) View Subject | View Object

but ACh is also released by non-neuronal tissues where it is involved in cell-to-cell communication, and con- trols essential functions such as cell proliferation, adhesion, migration, secretion, survival and apoptosis, in an autocrine, paracrine or juxtacrine manner PubMed:28901280

Appears in Networks:

bp(MESH:Apoptosis) negativeCorrelation p(MGI:Hpx) View Subject | View Object

In conclusion, an Hx-based therapy shows beneficial effects, in that it counteracts heme-induced proinflammatory activation of macrophages and attenuates some of its pathophysiologic consequences, such as chronic inflammation, hepatic fibrosis, and apoptosis (Figure 7E). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

bp(MESH:Apoptosis) increases a(MESH:"Cell-Derived Microparticles") View Subject | View Object

Activation, aging, and apoptosis of various cells, including RBCs, are accompanied by formation of microscopic extracellular membranous structures named microvesicles or microparticles (MPs). PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

bp(MESH:Apoptosis) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Apoptosis has been found to be a major rout for the elimination of cells after a variety of stresses including ROS and RNS [30]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

bp(MESH:Apoptosis) positiveCorrelation a(MESH:"Reactive Nitrogen Species") View Subject | View Object

Apoptosis has been found to be a major rout for the elimination of cells after a variety of stresses including ROS and RNS [30]. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

bp(MESH:Apoptosis) positiveCorrelation complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) View Subject | View Object

Figure 3a depicts the morphology of SHSY5Y cells after treated with various conditions. Compared with heme/H2O2 treatment, cells exposing to heme/ H2O2/NO2 − exacerbated cell apoptotic and reduced cell yield. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

bp(MESH:Apoptosis) positiveCorrelation complex(a(CHEBI:"hydrogen peroxide"), a(CHEBI:heme), a(CHEBI:nitrite)) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

bp(MESH:Apoptosis) negativeCorrelation p(HGNC:ALB) View Subject | View Object

However, pretreatment with 2 μM BSA or BSA-T, we found that both BSA and BSA-T efficiently inhibited heme/H2O2/NO2 −- induced cell apoptotic and increased cell yields. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

bp(MESH:Apoptosis) negativeCorrelation p(HGNC:ALB) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

bp(MESH:Apoptosis) negativeCorrelation p(HGNC:ALB, pmod(Ph, Tyr)) View Subject | View Object

However, pretreatment with 2 μM BSA or BSA-T, we found that both BSA and BSA-T efficiently inhibited heme/H2O2/NO2 −- induced cell apoptotic and increased cell yields. PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

bp(MESH:Apoptosis) negativeCorrelation p(HGNC:ALB, pmod(Ph, Tyr)) View Subject | View Object

As quantified in Fig. 3c, although heme/H2O2/NO2 − increased the apoptotic rate to 32 ± 6.4%, BSA or BSA-T pretreatment caused a statistically significant reduced apoptotic rate (10 ± 5.0% and 15 ± 6.1%, respectively). PubMed:30324533

Appears in Networks:
Annotations
MeSH
Hematoma
Text Location
Results

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.