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a(CHEBI:dibenziodolium)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
dibenziodolium
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 0

Out-Edges 5

a(CHEBI:dibenziodolium) decreases a(MESH:"Reactive Oxygen Species") View Subject | View Object

Corroborating recent studies that showed heme as an inductor of ROS generation via NADPHox in neutrophils, macrophages and in VSMC [7,8,19], the pretreatment of cells with DPI (10 mM), a NADPHox inhibitor [20], prevented heme-induced ROS production in A7r5 VSMC (Fig. 2A). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:dibenziodolium) decreases bp(GO:"cell proliferation") View Subject | View Object

Moreover, DPI strongly inhibited heme-induced VSMC migration (Fig. 2B) and blunted the proliferative capability of heme-treated VSMC that reached levels below the controls. (Fig. 2C), indicating that heme effects on VSMC migration and proliferation are modulated by NADPHox. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:dibenziodolium) decreases bp(GO:"cell migration") View Subject | View Object

Moreover, DPI strongly inhibited heme-induced VSMC migration (Fig. 2B) and blunted the proliferative capability of heme-treated VSMC that reached levels below the controls. (Fig. 2C), indicating that heme effects on VSMC migration and proliferation are modulated by NADPHox. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:dibenziodolium) decreases p(HGNC:TNF) View Subject | View Object

mROS scavenger (Mito-TEMPO) and NADPH oxidases inhibitors (apocynin and DPI) block TNF production induced by heme. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
leukocyte
MeSH
Liver
MeSH
Malaria
Text Location
Review

a(CHEBI:dibenziodolium) decreases bp(GO:"necroptotic process") View Subject | View Object

mROS scavenger (Mito-TEMPO) and NADPH oxidases inhibitors (apocynin and DPI) block heme-induced necroptosis. PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
leukocyte
MeSH
Liver
MeSH
Malaria
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.