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Sepsis

Name
Sepsis
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine") decreases act(a(CHEBI:"zinc(2+)")) View Subject | View Object

TPEN (20 mM), a chelator for Zn2þ, Fe2þ and Mn2þ, abolished the effects of Zn2þ (Fig. 1A). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

a(CHEBI:"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine") decreases act(a(CHEBI:"zinc(2+)")) View Subject | View Object

The Zn2þ (20 mM)-induced expression of PS on erythrocytes, which was inhibited by TPEN, was not observed by other divalent cations, including Mg2þ and Ca2þ (Fig. 2A). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

a(CHEBI:"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine") decreases a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

The Zn2þ (20 mM)-induced expression of PS on erythrocytes, which was inhibited by TPEN, was not observed by other divalent cations, including Mg2þ and Ca2þ (Fig. 2A). PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

a(CHEBI:"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine") decreases a(HM:"erythrocyte-endothelium adhesion") View Subject | View Object

TPEN also inhibited erythrocyte adhesion, but the effect at 20 mM was weaker compared to that in the HRG (100 mg/mL)- treatment group. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

a(CHEBI:"desferrioxamine B") decreases bp(MESH:"Bacterial Load") View Subject | View Object

Chelation of growth-medium iron with deferoxamine (DFO, 10 μM) led to a reduction in bacterial growth, as compared with non-chelated controls (Fig. 2a). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Sepsis
Text Location
Results

Showing 5 of 158 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.