1. Catalog
  2. Nodes
  3. path(MESH:Hypertension)

path(MESH:Hypertension)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Hypertension
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 3

Clearance systems in the brain-implications for Alzheimer disease. v1.0.1

Discriminative Stimulus Properties of S(−)-Nicotine: “A Drug for All Seasons v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 9

path(MESH:"Alzheimer Disease") association path(MESH:Hypertension) View Subject | View Object

Known envi- ronmental risk factors for LOAD include cardiovascular disease, and factors conferring a risk of cardiovascu- lar disease, such as diabetes mellitus and hypertension. Head trauma, physical and mental inactivity, and sleep impairment are additional risk factors for LOAD PubMed:26195256

Appears in Networks:

a(CHEBI:Mecamylamine) decreases path(MESH:Hypertension) View Subject | View Object

Mecamylamine (Inversine®, Vecamyl®; Fig. 3) was developed over 60 years ago and marketed as a ganglionic blocker for the treatment of hypertension (e.g., [127]) PubMed:28391535

Appears in Networks:

a(MESH:"Reactive Oxygen Species") positiveCorrelation path(MESH:Hypertension) View Subject | View Object

Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
smooth muscle cell
Text Location
Introduction

p(HGNC:HBB) increases path(MESH:Hypertension) View Subject | View Object

Intravenous infusion of cell-free hemoglobin induces hypertension in mice 205 (24). PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:HBB) increases path(MESH:Hypertension) View Subject | View Object

One of the mechanisms by which cell-free hemoglobin exerts its detrimental effects is its ability to effectively scavenge nitric oxide (NO), which in turn leads to perfusion disorders and an increased arterial and pulmonary arterial pressure [39, 40]. PubMed:29956069

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Sepsis
Text Location
Review

p(MGI:Hp) decreases path(MESH:Hypertension) View Subject | View Object

Recent data suggest that haptoglobin prevents hemoglobin-induced hypertension by 355 a similar mechanism (18). PubMed:28314763

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Diabetes Mellitus
Text Location
Introduction

p(MGI:Hp) decreases path(MESH:Hypertension) View Subject | View Object

In the 358 current study, we demonstrated that administration of human haptoglobin retained 359 cell-free hemoglobin in plasma, prevented hemoglobinuria, and reduced the 360 hemoglobin-induced hypertension in healthy awake mice (see Figure 1A). PubMed:28314763

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Diabetes Mellitus
Text Location
Introduction

complex(p(HGNC:HBB), p(MGI:Hp)) decreases path(MESH:Hypertension) View Subject | View Object

These results 230 suggest that co-injection of haptoglobin but not hemopexin with cell-free hemoglobin 231 can prevent hemoglobin-induced hypertension in awake, healthy mice. PubMed:28314763

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:"Pre-Eclampsia") positiveCorrelation path(MESH:Hypertension) View Subject | View Object

The classical findings that define PE are hypertension and proteinuria appearing after 20 weeks of gestation. PubMed:26368565

Appears in Networks:
Annotations
Text Location
Introduction

Out-Edges 3

path(MESH:Hypertension) association path(MESH:"Alzheimer Disease") View Subject | View Object

Known envi- ronmental risk factors for LOAD include cardiovascular disease, and factors conferring a risk of cardiovascu- lar disease, such as diabetes mellitus and hypertension. Head trauma, physical and mental inactivity, and sleep impairment are additional risk factors for LOAD PubMed:26195256

Appears in Networks:

path(MESH:Hypertension) positiveCorrelation path(MESH:"Pre-Eclampsia") View Subject | View Object

The classical findings that define PE are hypertension and proteinuria appearing after 20 weeks of gestation. PubMed:26368565

Appears in Networks:
Annotations
Text Location
Introduction

path(MESH:Hypertension) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
smooth muscle cell
Text Location
Introduction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.