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bp(MESH:"Cell Proliferation")

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Entity

Name
Cell Proliferation
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 3

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation") View Subject | View Object

The cytoplasmic in- crease in calcium triggers the secretion of mitogenic factors and activates the signalling cascades involved in cell prolif- eration, migration and angiogenesis and the inhibition of apoptosis PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Cell Proliferation") View Subject | View Object

Ubiquitin-mediated proteolysis of a variety of cellular proteins plays an important role in many basic cellular processes. Among these are regulation of cell cycle and division, differentiation and development, involvement in the cellular response to stress and extracellular effectors, morphogenesis of neuronal networks, modulation of cell surface receptors, ion channels and the secretory pathway, DNA repair, transcriptional regulation, transcriptional silencing, long-term memory, circadian rhythms, regulation of the immune and inflammatory responses,and biogenesis of organelles PubMed:14556719

Appears in Networks:

a(MESH:"Reactive Oxygen Species") increases bp(MESH:"Cell Proliferation") View Subject | View Object

Moreover, heme-derived ROS induce the proliferation of smooth muscle cells, that participate in vasculopathy associated with atherosclerosis and hypertension [15]. PubMed:28400318

Appears in Networks:
Annotations
Cell Ontology (CL)
smooth muscle cell
Text Location
Introduction

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.