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bp(MESH:"Erythrocyte Deformability")

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Entity

Name
Erythrocyte Deformability
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 15

a(CHEBI:heme) positiveCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

Sickle cell disease (SCD) and malaria are paradigmatic hemolytic disorders, in which alteration in the structure of red blood cells (RBCs) leads to the release of Hb and heme into the circulation. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

a(CHEBI:hydroperoxide) negativeCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

a(HM:"stored erythrocytes") decreases bp(MESH:"Erythrocyte Deformability") View Subject | View Object

Stored RBCs exhibit altered biophysical characteristics, including higher cell rigidity that accounts in part for impaired blood flow hemodynamics and adverse effects of RBC transfusion [26]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

a(HM:"stored erythrocytes") increases bp(MESH:"Erythrocyte Deformability") View Subject | View Object

For example, Hb and subsequently, hemin accumulate during storage of human blood as RBC membrane integrity decreases [4]. PubMed:30281034

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(MESH:"Reactive Oxygen Species") negativeCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

bp(MESH:"Erythrocyte Count") positiveCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

The mechanism behind this erythrocyte loss is not well understood but may be related to reduced erythrocyte deformability, accelerated senescence, or to complement or antibody-mediated (anti-erythrocyte) erythrophagocytosis [79]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Anemia, Sickle Cell
Text Location
Review

bp(MESH:"Oxidative Stress") negativeCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

It has been shown that RBC oxidative stress that damages the membrane reduces the deformability and flexibility of cells. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

p(HGNC:HBB) positiveCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

Sickle cell disease (SCD) and malaria are paradigmatic hemolytic disorders, in which alteration in the structure of red blood cells (RBCs) leads to the release of Hb and heme into the circulation. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

p(MGI:Prdx2) positiveCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

Figure 4 shows a significant decrease in the elongation index, which is a measure of deformability, for the PRDX2 knockout mice. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

p(MGI:Prdx2) positiveCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

p(MGI:Sod1) causesNoChange bp(MESH:"Erythrocyte Deformability") View Subject | View Object

No significant change in the elongation index was found for the SOD1 knockout mice. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

path(HP:"Diabetes mellitus") decreases bp(MESH:"Erythrocyte Deformability") View Subject | View Object

Some diseases, such as diabetes, hypertension, lower limb vein thrombosis, coronary heart disease, can secondarily alter the properties of RBCs, making them stiffer and prothrombotic [24]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

path(HP:"autoimmune hemolytic anemia") decreases bp(MESH:"Erythrocyte Deformability") View Subject | View Object

Other diseases, including -thalassemia, hemolytic anemias caused by RBC antibodies, and hereditary stomatocytosis, also commonly have RBCs with stiff membranes [23]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

path(MESH:Thalassemia) decreases bp(MESH:"Erythrocyte Deformability") View Subject | View Object

Other diseases, including -thalassemia, hemolytic anemias caused by RBC antibodies, and hereditary stomatocytosis, also commonly have RBCs with stiff membranes [23]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

path(MESH:Thrombosis) negativeCorrelation bp(MESH:"Erythrocyte Deformability") View Subject | View Object

Some diseases, such as diabetes, hypertension, lower limb vein thrombosis, coronary heart disease, can secondarily alter the properties of RBCs, making them stiffer and prothrombotic [24]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

Out-Edges 11

bp(MESH:"Erythrocyte Deformability") negativeCorrelation path(MESH:Thrombosis) View Subject | View Object

Some diseases, such as diabetes, hypertension, lower limb vein thrombosis, coronary heart disease, can secondarily alter the properties of RBCs, making them stiffer and prothrombotic [24]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

bp(MESH:"Erythrocyte Deformability") negativeCorrelation bp(MESH:"Oxidative Stress") View Subject | View Object

It has been shown that RBC oxidative stress that damages the membrane reduces the deformability and flexibility of cells. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

bp(MESH:"Erythrocyte Deformability") positiveCorrelation p(MGI:Prdx2) View Subject | View Object

Figure 4 shows a significant decrease in the elongation index, which is a measure of deformability, for the PRDX2 knockout mice. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

bp(MESH:"Erythrocyte Deformability") positiveCorrelation p(MGI:Prdx2) View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

bp(MESH:"Erythrocyte Deformability") negativeCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

bp(MESH:"Erythrocyte Deformability") negativeCorrelation a(CHEBI:hydroperoxide) View Subject | View Object

The role of PRDX2 in inhibiting impaired deformability can be attributed to both a reduction in ROS as well as a direct reaction of PRDX2 with protein hydroperoxides [52], which will inhibit the damage to cytoskeletal proteins required for impaired deformability. PubMed:23215741

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Discussion

bp(MESH:"Erythrocyte Deformability") positiveCorrelation p(HGNC:HBB) View Subject | View Object

Sickle cell disease (SCD) and malaria are paradigmatic hemolytic disorders, in which alteration in the structure of red blood cells (RBCs) leads to the release of Hb and heme into the circulation. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

bp(MESH:"Erythrocyte Deformability") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Sickle cell disease (SCD) and malaria are paradigmatic hemolytic disorders, in which alteration in the structure of red blood cells (RBCs) leads to the release of Hb and heme into the circulation. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

bp(MESH:"Erythrocyte Deformability") positiveCorrelation bp(MESH:"Erythrocyte Count") View Subject | View Object

The mechanism behind this erythrocyte loss is not well understood but may be related to reduced erythrocyte deformability, accelerated senescence, or to complement or antibody-mediated (anti-erythrocyte) erythrophagocytosis [79]. PubMed:26875449

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Anemia, Sickle Cell
Text Location
Review

bp(MESH:"Erythrocyte Deformability") decreases a(HM:"Platelet margination") View Subject | View Object

More rigid RBCs may be less able to squeeze through the capillaries and they also increase platelet margination described above, both of which increase the susceptibility to thrombosis [18]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

bp(MESH:"Erythrocyte Deformability") decreases path(MESH:Thrombosis) View Subject | View Object

More rigid RBCs may be less able to squeeze through the capillaries and they also increase platelet margination described above, both of which increase the susceptibility to thrombosis [18]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.