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  4. Osteoarthritis, Knee

Osteoarthritis, Knee

Name
Osteoarthritis, Knee
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:heme) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

a(CHEBI:heme) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

This is consistent with our findings here that both heme and Hb were associated with increased levels of synovial fluid A1M. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

a(CHEBI:heme) increases path(HM:"Oxidative damage") View Subject | View Object

These novel data support a role for A1M in the protection against oxidative damage due to extracellular Hb and heme in the joint in various knee arthropathies. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

a(MESH:"Reactive Oxygen Species") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

a(MESH:"Reactive Oxygen Species") positiveCorrelation bp(GO:"inflammatory response") View Subject | View Object

As a part of the inflammatory response after injury, oxidative stress due to formation of reactive oxygen species (ROS) is involved both in direct damage of cartilage components and as integral factors in cell signaling leading to cartilage degradation (Henrotin et al., 2003). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

Showing 5 of 57 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.