a(CHEBI:heme) increases a(MESH:"Reactive Oxygen Species")

View Subject View Object

PubMed:22954673

Corroborating recent studies that showed heme as an inductor of ROS generation via NADPHox in neutrophils, macrophages and in VSMC [7,8,19], the pretreatment of cells with DPI (10 mM), a NADPHox inhibitor [20], prevented heme-induced ROS production in A7r5 VSMC (Fig. 2A).

Related Edges 1

• a(CHEBI:dibenziodolium) decreases a(MESH:"Reactive Oxygen Species")

Cell Ontology (CL)

neutrophil

MeSH

Muscle, Smooth, Vascular

Text Location

Results

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---