1. Catalog
  2. Namespaces
  3. Text Location
  4. Introduction

Introduction

Name
Introduction
Namespace Keyword
TextLocation
Namespace
Text Location
Namespace Version
1.0.1
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/text-location/text-location-1.0.1.belanno

Sample Annotated Edges 5

a(CHEBI:"L-arginine") negativeCorrelation path(MESH:"Pulmonary Embolism") View Subject | View Object

Humans with severe PE have increased arginase-1 and decreased plasma L-arginine concentrations.[14] PubMed:26337933

Appears in Networks:
Annotations
Text Location
Introduction

a(CHEBI:"carbon monoxide") negativeCorrelation path(MESH:"Vascular System Injuries") View Subject | View Object

By-products of heme and iron metabolism, such as heme oxygenase-dependent generation of carbon monoxide (CO), have antioxidant and anti-inflammatory protective functions against iron-induced vascular damage (33); therefore we examined the impact of CO donors on collagen exposure and thrombus formation in the ex vivo vascular injury model. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"carbon monoxide") negativeCorrelation a(HM:Thrombus) View Subject | View Object

Pretreating anticoagulated whole blood with tricarbonyldichlororuthenium(II) dimer, a CO donor, significantly reduced collagen exposure (Fig. 5A) and thrombus formation (Fig. 5B) induced by FeCl3. PubMed:19276082

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Aorta
Text Location
Introduction

a(CHEBI:"carbon monoxide") positiveCorrelation deg(a(CHEBI:heme)) View Subject | View Object

Within cells, heme is catabolized by the activity of heme oxygenases (inducible HO-1 and constitutive HO-2) into iron, carbon monoxide, and biliverdin. PubMed:26675351

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Introduction

a(CHEBI:"hydrogen peroxide") negativeCorrelation p(MGI:Prdx2) View Subject | View Object

Peroxiredoxin-2 (Prx-2) has emerged as the critical antioxidant protecting RBCs from H2O2 produced endogenously (by Hb autoxidation and subsequent superoxide dismutation) and exogenously (e.g., from activated neutrophils) at low (physiologic) concentrations (11, 32, 38, 40, 43, 45) and, therefore, may limit oxidative injury to other cells/tissues in the vasculature (6, 57). PubMed:25264713

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Introduction

Showing 5 of 373 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.