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p(HGNC:AMBP)

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Entity

Name
AMBP
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 27

a(CHEBI:heme) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23]. PubMed:24489717

Appears in Networks:
Annotations
Text Location
Introduction

a(CHEBI:heme) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

a(CHEBI:heme) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

This is consistent with our findings here that both heme and Hb were associated with increased levels of synovial fluid A1M. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

a(MESH:"Reactive Oxygen Species") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23]. PubMed:24489717

Appears in Networks:
Annotations
Text Location
Introduction

a(MESH:"Reactive Oxygen Species") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

a(MESH:Cytokines) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

However, with A1M increased in both synovial fluid and serum in AIA, the present study further suggests that, in addition to heme and ROS, A1M may be regulated by inflammatory cytokines. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

a(MESH:Lymphocytes) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

a(MESH:Monocytes) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

bp(HP:"regulation of systemic arterial blood pressure") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

However, A1M treatment led to a significant reduction in systolic, diastolic and mean arterial blood pressure 24 hours after the first injection (Figure 2, and Figure S1), but no change in heart rate (Figure S1). PubMed:24489717

Appears in Networks:
Annotations
Text Location
Results

bp(MESH:"Leukocyte Count") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

bp(MESH:"Platelet Count") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

bp(MESH:"Wound Healing") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

In addition to the obvious protective benefit of exogenous A1M binding and neutralizing cell-free Hb and heme, it may also be beneficial as a repair mechanism in already damaged cartilage, since in vitro studies showed that collagen fibrils were restored to normal by addition of recombinant A1M after destruction already had begun (Olsson et al., 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:HBB) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23]. PubMed:24489717

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:HBB) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

This is consistent with our findings here that both heme and Hb were associated with increased levels of synovial fluid A1M. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(HM:"Oxidative damage") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Of particular interest for this investigation is that the expression of A1M has been shown to be up-regulated in several cells and tissues during oxidative stress conditions in response to elevated levels of ROS, Hb, and free heme (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

path(HP:Preeclampsia) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

There are many examples of studies that have shown increased A1M in serum or urine to be a biomarker of diseases such as preeclampsia (Anderson et al., 2011, 2016; Gram et al., 2015), and kidney failure (Terzi et al., 2014; Kang et al., 2015). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Serum
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:"Kidney Failure, Chronic") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

There are many examples of studies that have shown increased A1M in serum or urine to be a biomarker of diseases such as preeclampsia (Anderson et al., 2011, 2016; Gram et al., 2015), and kidney failure (Terzi et al., 2014; Kang et al., 2015). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Serum
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:"Knee Injuries") increases p(HGNC:AMBP) View Subject | View Object

Altogether, our best interpretation of these data is that increased levels of cell-free Hb and heme in synovial fluid early after injury triggered an increase in the synovial fluid A1M concentration that appeared to be protective of oxidative damage. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:"Osteoarthritis, Knee") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

In similarity with both studies, we found detectable concentrations of A1M in synovial fluid in subjects with knee OA. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:"Osteoarthritis, Knee") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Finally, we note that in AIA A1M is increased both locally in the joint fluid and systemically in serum, whereas in knee injury A1M is increased only in the joint fluid. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:"Pre-Eclampsia") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Analysis of plasma levels of the heme- and radical scavenger A1M showed a statistically significant increase of plasma A1M concentration in women with PE (p-value 0.035) as compared to controls (Table 3). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

path(MESH:"Pre-Eclampsia") positiveCorrelation p(HGNC:AMBP) View Subject | View Object

In line with previously published studies [13,14] the extravascular heme- and radical scavenger A1M was significantly increased in plasma of women with PE. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Discussion

path(MESH:Arthritis) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

The highest concentrations of A1M, both in synovial fluid and serum, were found in the AIA (Figure 1A). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Results

path(MESH:Arthritis) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Our study extends those findings to include elevated A1M in both serum and synovial fluid as a biomarker of AIA, as suggested by the ROC-curves with AUCs close to 0.8. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:Arthritis) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

Finally, we note that in AIA A1M is increased both locally in the joint fluid and systemically in serum, whereas in knee injury A1M is increased only in the joint fluid. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

path(MESH:Hemorrhage) positiveCorrelation p(HGNC:AMBP) View Subject | View Object

In serum, the A1M concentration in the AIA group was between 1.3- and 1.4-fold higher compared to the injury and osteoarthritis groups (p = 0.035 and 0.030, respectively), whereas the 1.2-fold higher mean concentration compared to the reference group was not statistically significan (p = 0.15; Figure 1A). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Results

path(MESH:Necrosis) negativeCorrelation p(HGNC:AMBP) View Subject | View Object

Podocyte necrosis was also frequently observed, leading to impaired glomerular barrier morphology with large basement membrane fenestrations (Figure 7B, arrowheads). Similar phenomena were observed in proximal tubules where starvation induced tubular damage with cell necrosis and an overall disturbed tubular morphology (Figure 7A, middle panel). These overall effects were reversed by A1M (Figure 7 A and B, lower panels). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Podocytes
Text Location
Results

Out-Edges 40

p(HGNC:AMBP) positiveCorrelation p(HGNC:HBB) View Subject | View Object

The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23]. PubMed:24489717

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:AMBP) positiveCorrelation p(HGNC:HBB) View Subject | View Object

This is consistent with our findings here that both heme and Hb were associated with increased levels of synovial fluid A1M. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme) View Subject | View Object

The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23]. PubMed:24489717

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:AMBP) increases deg(a(CHEBI:heme)) View Subject | View Object

Furthermore, the plasmaand extravascular reductase and heme- and radical scavenger α1-microglobulin (A1M) binds and degrades free heme and can reduce metHb [28–30]. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Placenta
Text Location
Introduction

p(HGNC:AMBP) decreases a(CHEBI:heme) View Subject | View Object

Excess extracellular heme is weakly bound to albumin [22], /1-microglobulin (which can also degrade heme) [23] and, most likely, to other plasma proteins and lipoproteins; there is a dynamic nature to such interactions. PubMed:26875449

Appears in Networks:
Annotations
Text Location
Review

p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme) View Subject | View Object

Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation a(CHEBI:heme) View Subject | View Object

This is consistent with our findings here that both heme and Hb were associated with increased levels of synovial fluid A1M. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

The expression of A1M is up-regulated by elevated levels of free Hb, heme and ROS [23]. PubMed:24489717

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:AMBP) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Expression and synthesis of A1M has been shown to be upregulated in cells after exposure to heme and ROS (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation bp(HP:"regulation of systemic arterial blood pressure") View Subject | View Object

However, A1M treatment led to a significant reduction in systolic, diastolic and mean arterial blood pressure 24 hours after the first injection (Figure 2, and Figure S1), but no change in heart rate (Figure S1). PubMed:24489717

Appears in Networks:
Annotations
Text Location
Results

p(HGNC:AMBP) decreases bp(MESH:Phagocytosis) View Subject | View Object

The placenta histology revealed an increased erythrophagocytosis in the starved placebo treated animals compared to controls. A1M-treatment appeared to attenuate phagocytosis (Figure 5). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Results

p(HGNC:AMBP) negativeCorrelation path(MESH:Necrosis) View Subject | View Object

Podocyte necrosis was also frequently observed, leading to impaired glomerular barrier morphology with large basement membrane fenestrations (Figure 7B, arrowheads). Similar phenomena were observed in proximal tubules where starvation induced tubular damage with cell necrosis and an overall disturbed tubular morphology (Figure 7A, middle panel). These overall effects were reversed by A1M (Figure 7 A and B, lower panels). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Podocytes
Text Location
Results

p(HGNC:AMBP) causesNoChange a(CHEBI:creatinine) View Subject | View Object

Plasma creatinine concentration increased significantly in the placebo treated animals at 4 hours of follow-up, but not in the A1M treated group (Figure 9B). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

p(HGNC:AMBP) positiveCorrelation bp(MESH:"Platelet Count") View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

p(HGNC:AMBP) positiveCorrelation bp(MESH:"Leukocyte Count") View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

p(HGNC:AMBP) positiveCorrelation a(MESH:Monocytes) View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

p(HGNC:AMBP) positiveCorrelation a(MESH:Lymphocytes) View Subject | View Object

However, A1M treatment resulted in a transient increase in the total number of platelets 48 hours after the first injection and peripheral white blood cells, monocytes and lymphocytes 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

p(HGNC:AMBP) increases p(HGNC:IL6) View Subject | View Object

Treatment with A1M led to a small, non-significant, transient increase in plasma interleukin 6 24 hours after the first injection. PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Kidney Tubules, Proximal
Text Location
Results

p(HGNC:AMBP) decreases p(HGNC:SOD1) View Subject | View Object

Starvation led to a significantly down-regulation of the oxidative stress-related SOD1 (p,0.008) and catalase (p,0.043) in blood, but a 2.6-fold up-regulation of catalase in placenta (Figure 10A). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Blood
Text Location
Results

p(HGNC:AMBP) decreases a(CHEBI:Catalase) View Subject | View Object

Starvation led to a significantly down-regulation of the oxidative stress-related SOD1 (p,0.008) and catalase (p,0.043) in blood, but a 2.6-fold up-regulation of catalase in placenta (Figure 10A). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Blood
Text Location
Results

p(HGNC:AMBP) increases a(CHEBI:Catalase) View Subject | View Object

Starvation led to a significantly down-regulation of the oxidative stress-related SOD1 (p,0.008) and catalase (p,0.043) in blood, but a 2.6-fold up-regulation of catalase in placenta (Figure 10A). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Placenta
Text Location
Results

p(HGNC:AMBP) increases p(HGNC:SOD2) View Subject | View Object

Treatment of starved ewes with A1M up-regulated the expression of SOD2 (p,0.043) and down-regulated the expression of s-Flt1 (p,0.012), in blood (Figure 11). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Blood
Text Location
Results

p(HGNC:AMBP) decreases p(HGNC:FLT1) View Subject | View Object

Treatment of starved ewes with A1M up-regulated the expression of SOD2 (p,0.043) and down-regulated the expression of s-Flt1 (p,0.012), in blood (Figure 11). PubMed:24489717

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Blood
Text Location
Results

p(HGNC:AMBP) positiveCorrelation path(MESH:"Pre-Eclampsia") View Subject | View Object

Analysis of plasma levels of the heme- and radical scavenger A1M showed a statistically significant increase of plasma A1M concentration in women with PE (p-value 0.035) as compared to controls (Table 3). PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Results

p(HGNC:AMBP) positiveCorrelation path(MESH:"Pre-Eclampsia") View Subject | View Object

In line with previously published studies [13,14] the extravascular heme- and radical scavenger A1M was significantly increased in plasma of women with PE. PubMed:26368565

Appears in Networks:
Annotations
Cell Ontology (CL)
hepatocyte
MeSH
Plasma
MeSH
Pre-Eclampsia
Text Location
Discussion

p(HGNC:AMBP) decreases bp(MESH:"Oxidative Stress") View Subject | View Object

Another protein that in the last decade has been shown to play a central role as a protective protein against oxidative stress is a1-microglobulin (A1M) (Åkerström and Gram, 2014). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

p(HGNC:AMBP) positiveCorrelation path(HM:"Oxidative damage") View Subject | View Object

Of particular interest for this investigation is that the expression of A1M has been shown to be up-regulated in several cells and tissues during oxidative stress conditions in response to elevated levels of ROS, Hb, and free heme (Olsson et al., 2007, 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Introduction

p(HGNC:AMBP) decreases path(HM:"Oxidative damage") View Subject | View Object

When adjusted for their respective absolute concentrations, the higher the proportion sf-A1M to sf-heme or sf-Hb, the less oxidative damage measured as protein carbonyl groups in synovial fluid. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) decreases path(HM:"Oxidative damage") View Subject | View Object

These novel data support a role for A1M in the protection against oxidative damage due to extracellular Hb and heme in the joint in various knee arthropathies. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) decreases path(HM:"Oxidative damage") View Subject | View Object

Altogether, our best interpretation of these data is that increased levels of cell-free Hb and heme in synovial fluid early after injury triggered an increase in the synovial fluid A1M concentration that appeared to be protective of oxidative damage. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation path(MESH:Arthritis) View Subject | View Object

The highest concentrations of A1M, both in synovial fluid and serum, were found in the AIA (Figure 1A). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Results

p(HGNC:AMBP) positiveCorrelation path(MESH:Arthritis) View Subject | View Object

Our study extends those findings to include elevated A1M in both serum and synovial fluid as a biomarker of AIA, as suggested by the ROC-curves with AUCs close to 0.8. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation path(MESH:Arthritis) View Subject | View Object

Finally, we note that in AIA A1M is increased both locally in the joint fluid and systemically in serum, whereas in knee injury A1M is increased only in the joint fluid. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation path(MESH:Hemorrhage) View Subject | View Object

In serum, the A1M concentration in the AIA group was between 1.3- and 1.4-fold higher compared to the injury and osteoarthritis groups (p = 0.035 and 0.030, respectively), whereas the 1.2-fold higher mean concentration compared to the reference group was not statistically significan (p = 0.15; Figure 1A). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Results

p(HGNC:AMBP) positiveCorrelation path(HP:Preeclampsia) View Subject | View Object

There are many examples of studies that have shown increased A1M in serum or urine to be a biomarker of diseases such as preeclampsia (Anderson et al., 2011, 2016; Gram et al., 2015), and kidney failure (Terzi et al., 2014; Kang et al., 2015). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Serum
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation path(MESH:"Kidney Failure, Chronic") View Subject | View Object

There are many examples of studies that have shown increased A1M in serum or urine to be a biomarker of diseases such as preeclampsia (Anderson et al., 2011, 2016; Gram et al., 2015), and kidney failure (Terzi et al., 2014; Kang et al., 2015). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Serum
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation path(MESH:"Osteoarthritis, Knee") View Subject | View Object

In similarity with both studies, we found detectable concentrations of A1M in synovial fluid in subjects with knee OA. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation path(MESH:"Osteoarthritis, Knee") View Subject | View Object

Finally, we note that in AIA A1M is increased both locally in the joint fluid and systemically in serum, whereas in knee injury A1M is increased only in the joint fluid. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation a(MESH:Cytokines) View Subject | View Object

However, with A1M increased in both synovial fluid and serum in AIA, the present study further suggests that, in addition to heme and ROS, A1M may be regulated by inflammatory cytokines. PubMed:30505280

Appears in Networks:
Annotations
MeSH
Synovial Fluid
MeSH
Osteoarthritis, Knee
Text Location
Discussion

p(HGNC:AMBP) positiveCorrelation bp(MESH:"Wound Healing") View Subject | View Object

In addition to the obvious protective benefit of exogenous A1M binding and neutralizing cell-free Hb and heme, it may also be beneficial as a repair mechanism in already damaged cartilage, since in vitro studies showed that collagen fibrils were restored to normal by addition of recombinant A1M after destruction already had begun (Olsson et al., 2011). PubMed:30505280

Appears in Networks:
Annotations
MeSH
Knee
MeSH
Osteoarthritis, Knee
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.