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bp(MESH:"Platelet Activation")

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Entity

Name
Platelet Activation
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 21

a(CHEBI:"iron(2+)") increases bp(MESH:"Platelet Activation") View Subject | View Object

Finally, ferrous iron, through Fenton-derived hydroxyl radical species production and protein kinase C function, activates platelets (Iuliano et al, 1994). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:"iron(2+)") positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

There are in vitro and animal model data linking increased free Hb, heme, and iron to inflammation, 6 infection,7 platelet (PLT) activation,8,9 vasculopathy, 10 and thrombosis. PubMed:29603246

Appears in Networks:
Annotations
Text Location
Introduction

a(CHEBI:"nitric oxide") decreases bp(MESH:"Platelet Activation") View Subject | View Object

Platelets may be activated during haemolysis by several different mechanisms involving decreased NO levels, increased pro-inflammatory cytokines and mediators, and ROS. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:"nitric oxide") decreases bp(MESH:"Platelet Activation") View Subject | View Object

Another mechanism for platelet activation by RBC lysate is extracellular hemoglobin, which enhances platelet activation by lowering NO bioavailability [ 29]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

a(CHEBI:"nitric oxide") decreases bp(MESH:"Platelet Activation") View Subject | View Object

Both processes decrease the availability of NO, which normally maintains smooth muscle cell relaxation, inhibits platelet activation and aggregation, and has anti-inflammatory effects on the endothelium. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

a(CHEBI:heme) positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

There are in vitro and animal model data linking increased free Hb, heme, and iron to inflammation, 6 infection,7 platelet (PLT) activation,8,9 vasculopathy, 10 and thrombosis. PubMed:29603246

Appears in Networks:
Annotations
Text Location
Introduction

a(MESH:"Blood Transfusion") increases bp(MESH:"Platelet Activation") View Subject | View Object

In acute coronary syndrome, RBC transfusion increases platelet reactivity [31]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Acute Coronary Syndrome
Text Location
Review

a(HM:Immunothrombosis) positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

The cascade of immunothrombosis includes platelet activation and secretion, which may result in a local increase in Zn2þ concentration because of the presence of Zn2þ in platelet dense granules. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

a(MESH:"Adenosine Diphosphate") positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

ADP induces platelet activation and may also contribute to transfusion-related vascular thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Cell-Derived Microparticles") positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

Surface accumulation of MAC may be at least partially responsible for the activated platelet phenotype seen in patients with primary Cys89Tyr CD59 mutation, as manifested both by increased CD62P expression and monocyte-platelet aggregates. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

a(MESH:"Extracellular Traps") increases bp(MESH:"Platelet Activation") View Subject | View Object

Thus, NETs recruit RBCs, activate platelets and promote fibrin deposition; they are a previously unrecognized link between haemolysis and thrombosis that may further explain this epidemiological association. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:"Reactive Oxygen Species") increases bp(MESH:"Platelet Activation") View Subject | View Object

Platelets may be activated during haemolysis by several different mechanisms involving decreased NO levels, increased pro-inflammatory cytokines and mediators, and ROS. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(MESH:Cytokines) increases bp(MESH:"Platelet Activation") View Subject | View Object

Platelets may be activated during haemolysis by several different mechanisms involving decreased NO levels, increased pro-inflammatory cytokines and mediators, and ROS. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

bp(HM:"Monocyte-platelet aggregation") positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

In contrast to platelet lysis, platelet activation is clearly seen, based on both the higher expression of CD62P (Fig. 3B) and increased coaggregation with white blood cells. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

bp(HM:"Monocyte-platelet aggregation") positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

Surface accumulation of MAC may be at least partially responsible for the activated platelet phenotype seen in patients with primary Cys89Tyr CD59 mutation, as manifested both by increased CD62P expression and monocyte-platelet aggregates. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

p(HGNC:HBB) increases bp(MESH:"Platelet Activation") View Subject | View Object

Another mechanism for platelet activation by RBC lysate is extracellular hemoglobin, which enhances platelet activation by lowering NO bioavailability [ 29]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
Text Location
Review

p(HGNC:HBB) positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

There are in vitro and animal model data linking increased free Hb, heme, and iron to inflammation, 6 infection,7 platelet (PLT) activation,8,9 vasculopathy, 10 and thrombosis. PubMed:29603246

Appears in Networks:
Annotations
Text Location
Introduction

p(HGNC:SELP) positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

In contrast to platelet lysis, platelet activation is clearly seen, based on both the higher expression of CD62P (Fig. 3B) and increased coaggregation with white blood cells. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

p(HGNC:SELP) positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

Surface accumulation of MAC may be at least partially responsible for the activated platelet phenotype seen in patients with primary Cys89Tyr CD59 mutation, as manifested both by increased CD62P expression and monocyte-platelet aggregates. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

path(HP:"Paroxysmal nocturnal hemoglobinuria") increases bp(MESH:"Platelet Activation") View Subject | View Object

In PNH, uncontrolled complement activity leads to systemic complications, principally through intravascular haemolysis and platelet activation. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
Text Location
Review

path(MESH:Thrombosis) positiveCorrelation bp(MESH:"Platelet Activation") View Subject | View Object

In addition, reduced NO bioavailability induces platelet activation and aggregation, leading to thrombosis in a mouse model of intravascular haemolysis (Hu et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

Out-Edges 12

bp(MESH:"Platelet Activation") positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

In addition, reduced NO bioavailability induces platelet activation and aggregation, leading to thrombosis in a mouse model of intravascular haemolysis (Hu et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

bp(MESH:"Platelet Activation") positiveCorrelation a(MESH:"Adenosine Diphosphate") View Subject | View Object

ADP induces platelet activation and may also contribute to transfusion-related vascular thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

bp(MESH:"Platelet Activation") positiveCorrelation a(HM:Immunothrombosis) View Subject | View Object

The cascade of immunothrombosis includes platelet activation and secretion, which may result in a local increase in Zn2þ concentration because of the presence of Zn2þ in platelet dense granules. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

bp(MESH:"Platelet Activation") increases a(CHEBI:"zinc(2+)") View Subject | View Object

The cascade of immunothrombosis includes platelet activation and secretion, which may result in a local increase in Zn2þ concentration because of the presence of Zn2þ in platelet dense granules. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
MeSH
Sepsis
Text Location
Results

bp(MESH:"Platelet Activation") positiveCorrelation p(HGNC:HBB) View Subject | View Object

There are in vitro and animal model data linking increased free Hb, heme, and iron to inflammation, 6 infection,7 platelet (PLT) activation,8,9 vasculopathy, 10 and thrombosis. PubMed:29603246

Appears in Networks:
Annotations
Text Location
Introduction

bp(MESH:"Platelet Activation") positiveCorrelation a(CHEBI:heme) View Subject | View Object

There are in vitro and animal model data linking increased free Hb, heme, and iron to inflammation, 6 infection,7 platelet (PLT) activation,8,9 vasculopathy, 10 and thrombosis. PubMed:29603246

Appears in Networks:
Annotations
Text Location
Introduction

bp(MESH:"Platelet Activation") positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

There are in vitro and animal model data linking increased free Hb, heme, and iron to inflammation, 6 infection,7 platelet (PLT) activation,8,9 vasculopathy, 10 and thrombosis. PubMed:29603246

Appears in Networks:
Annotations
Text Location
Introduction

bp(MESH:"Platelet Activation") positiveCorrelation p(HGNC:SELP) View Subject | View Object

In contrast to platelet lysis, platelet activation is clearly seen, based on both the higher expression of CD62P (Fig. 3B) and increased coaggregation with white blood cells. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

bp(MESH:"Platelet Activation") positiveCorrelation p(HGNC:SELP) View Subject | View Object

Surface accumulation of MAC may be at least partially responsible for the activated platelet phenotype seen in patients with primary Cys89Tyr CD59 mutation, as manifested both by increased CD62P expression and monocyte-platelet aggregates. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

bp(MESH:"Platelet Activation") positiveCorrelation bp(HM:"Monocyte-platelet aggregation") View Subject | View Object

In contrast to platelet lysis, platelet activation is clearly seen, based on both the higher expression of CD62P (Fig. 3B) and increased coaggregation with white blood cells. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

bp(MESH:"Platelet Activation") positiveCorrelation bp(HM:"Monocyte-platelet aggregation") View Subject | View Object

Surface accumulation of MAC may be at least partially responsible for the activated platelet phenotype seen in patients with primary Cys89Tyr CD59 mutation, as manifested both by increased CD62P expression and monocyte-platelet aggregates. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

bp(MESH:"Platelet Activation") positiveCorrelation a(MESH:"Cell-Derived Microparticles") View Subject | View Object

Surface accumulation of MAC may be at least partially responsible for the activated platelet phenotype seen in patients with primary Cys89Tyr CD59 mutation, as manifested both by increased CD62P expression and monocyte-platelet aggregates. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.