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a(CHEBI:protoporphyrin)

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Entity

Name
protoporphyrin
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

complex(a(CHEBI:"tin atom"), a(CHEBI:protoporphyrin)) hasComponent a(CHEBI:protoporphyrin) View Subject | View Object

Appears in Networks:

Out-Edges 5

a(CHEBI:protoporphyrin) increases p(MGI:Il1b) View Subject | View Object

ELISA analysis displayed that the concentration of IL-1b in culture supernatants was significantly enhanced after stimulated by heme and PPIX. PubMed:24464629

Appears in Networks:
Annotations
MeSH
Kidney
Text Location
Results

a(CHEBI:protoporphyrin) causesNoChange p(HGNC:TNF) View Subject | View Object

Importantly, protoporphyrin did not induce TNFα, suggesting a critical proinflammatory role for iron within the heme moiety (supplemental Figure 8). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

a(CHEBI:protoporphyrin) causesNoChange a(MESH:"Reactive Oxygen Species") View Subject | View Object

By contrast, treatment of macrophages with PPIX failed to increase the ROS production and ferroportin expression, implying that iron within the heme moiety was required for the observed effects (Fig. 7B). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:protoporphyrin) causesNoChange p(MGI:Slc40a1) View Subject | View Object

By contrast, treatment of macrophages with PPIX failed to increase the ROS production and ferroportin expression, implying that iron within the heme moiety was required for the observed effects (Fig. 7B). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:protoporphyrin) increases p(MGI:Hmox1) View Subject | View Object

In contrast, PPIX treatment of macrophages was capable of inducing Hmox-1 expression (Fig. 7C), indicating that PPIX was taken up by macrophages and catabolized (13). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.