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beta-Thalassemia

Name
beta-Thalassemia
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation path(HP:Hypercoagulability) View Subject | View Object

The abnormal phospholipid membrane asymmetry present in the RBCs of b-thalassaemia and SCD patients, with resultant phosphatidylserine exposure, appears to play a significant role in the aetiology of the observed hypercoagulable state and in the link between haemolysis and thrombosis (Ataga et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") increases path(MESH:Hemolysis) View Subject | View Object

The abnormal phospholipid membrane asymmetry present in the RBCs of b-thalassaemia and SCD patients, with resultant phosphatidylserine exposure, appears to play a significant role in the aetiology of the observed hypercoagulable state and in the link between haemolysis and thrombosis (Ataga et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") increases path(MESH:Thrombosis) View Subject | View Object

The abnormal phospholipid membrane asymmetry present in the RBCs of b-thalassaemia and SCD patients, with resultant phosphatidylserine exposure, appears to play a significant role in the aetiology of the observed hypercoagulable state and in the link between haemolysis and thrombosis (Ataga et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

Because of the large numbers of RBCs present in the blood, even a small fraction of RBCs with phosphatidylserine exposure can result in prothrombotic conditions. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation a(MESH:"Erythrocytes, Abnormal") View Subject | View Object

Under conditions of apoptosis or RBC damage, such as high shear rates, inflammation, or oxidative stress, RBCs can lose membrane asymmetry and expose phosphatidylserine [43]. PubMed:28458720

Appears in Networks:
Annotations
MeSH
Veins
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

Showing 5 of 101 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.