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neutrophil

Name
neutrophil
Namespace Keyword
Cell
Namespace
Cell Ontology (CL)
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell/cell-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases bp(GO:"cell proliferation") View Subject | View Object

In VSMC pretreated with the ERK-2 inhibitor PD98059 (10 mM), migration induced by heme was partially inhibited (Fig. 3A) and heme proliferative effect on VSMC was impaired (Fig. 3B). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases bp(GO:"cell migration") View Subject | View Object

In VSMC pretreated with the ERK-2 inhibitor PD98059 (10 mM), migration induced by heme was partially inhibited (Fig. 3A) and heme proliferative effect on VSMC was impaired (Fig. 3B). PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:"adenosine triphosphate") positiveCorrelation complex(a(CHEBI:heme), p(HGNC:ALB)) View Subject | View Object

In contrast, less ATP depletion was observed during exposure to heme-albumin, and no effect could be detected when either cell type was exposed to metHb or oxyHb at concentrations of up to 500 lmolL1, even in the absence of serum. PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Human Umbilical Vein Endothelial Cells
Text Location
Results

a(CHEBI:"zinc protoporphyrin") decreases act(p(RGD:Hmox1)) View Subject | View Object

Fig. 4 shows that the inhibition of HO activity by both, SnPP (Fig. 4A) or ZnPP (Fig. 4B), potentiates the effect of heme on VSMC proliferation. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

a(CHEBI:"zinc protoporphyrin") decreases act(p(RGD:Hmox1)) View Subject | View Object

Additionally, it was observed that inhibition of HO-1 by ZnPP induced a further increase in hemeinduced ROS production (Fig. 4C), suggesting that activation of HO system attenuates the NADPHox-dependent activation of VSMC induced by heme. PubMed:22954673

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
MeSH
Muscle, Smooth, Vascular
Text Location
Results

Showing 5 of 91 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.