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a(CHEBI:lipopolysaccharide)

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Entity

Name
lipopolysaccharide
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 3

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0

Anatabine ameliorates experimental autoimmune thyroiditis. v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 8

composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) hasComponent a(CHEBI:lipopolysaccharide) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide), a(MESH:Blood)) hasComponent a(CHEBI:lipopolysaccharide) View Subject | View Object

Appears in Networks:

a(CHEBI:"iron(2+)") positiveCorrelation a(CHEBI:lipopolysaccharide) View Subject | View Object

We showed that simulation of macrophages with LPS resulted in significant reduction in ferroportin mRNA and protein expression and enhanced intracellular iron deposition throughout all time points tested (Fig. 5A–D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:"iron(2+)") positiveCorrelation a(CHEBI:lipopolysaccharide) View Subject | View Object

This dramatically contrasts the iron phenotype that develops in response to LPS, hallmarked by high intracellular iron levels and low ferroportin expression (10, 20, 48). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Discussion

complex(a(CHEBI:lipopolysaccharide), p(HGNC:TLR4)) hasComponent a(CHEBI:lipopolysaccharide) View Subject | View Object

Appears in Networks:

p(MGI:Slc40a1) negativeCorrelation a(CHEBI:lipopolysaccharide) View Subject | View Object

We showed that simulation of macrophages with LPS resulted in significant reduction in ferroportin mRNA and protein expression and enhanced intracellular iron deposition throughout all time points tested (Fig. 5A–D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

p(MGI:Slc40a1) negativeCorrelation a(CHEBI:lipopolysaccharide) View Subject | View Object

This dramatically contrasts the iron phenotype that develops in response to LPS, hallmarked by high intracellular iron levels and low ferroportin expression (10, 20, 48). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Discussion

r(MGI:Slc40a1) negativeCorrelation a(CHEBI:lipopolysaccharide) View Subject | View Object

We showed that simulation of macrophages with LPS resulted in significant reduction in ferroportin mRNA and protein expression and enhanced intracellular iron deposition throughout all time points tested (Fig. 5A–D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

Out-Edges 28

a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) View Subject | View Object

An increased STAT3 (Mann–Whitney U=0, Z=-2.309, P=0.021) and p65 NFkB phosphorylation (Mann–Whitney U=0, Z=-2.309, p=0.021) was observed in LPS treated microglia (Fig. 3) PubMed:23178521

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell

a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) View Subject | View Object

We observed that anatabine significantly suppressed the stimulation of p65 NFkB and STAT3 phosphorylation by LPS in microglia (Fig. 3) PubMed:23178521

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell

a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) View Subject | View Object

Following a 24 h incubation with LPS, a significant stimulation of STAT3 (Mann– Whitney U=0, Z=-2.882, P=0.004) and p65 NFkB phosphorylation was observed (Mann–Whitney U=1, Z=-2.722, P=0.006) PubMed:23178521

Appears in Networks:
Annotations
Cell Ontology (CL)
mononuclear cell

a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) View Subject | View Object

An increased STAT3 (Mann–Whitney U=0, Z=-2.309, P=0.021) and p65 NFkB phosphorylation (Mann–Whitney U=0, Z=-2.309, p=0.021) was observed in LPS treated microglia (Fig. 3) PubMed:23178521

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell

a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) View Subject | View Object

We observed that anatabine significantly suppressed the stimulation of p65 NFkB and STAT3 phosphorylation by LPS in microglia (Fig. 3) PubMed:23178521

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell

a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) View Subject | View Object

Similarly, LPS induced p65 NFkB phosphorylation in microglia was significantly inhibited with 10 mg/ml of anatabine (Mann–Whitney U=0, Z=-2.309, P=0.021), with 100 mg/ml of anatabine (Mann– Whitney U=0, Z=-2.309, P=0.021), with 300 mg/ml of anatabine (Mann–Whitney U=0, Z=-2.309, P=0.021) PubMed:23178521

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell

a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) View Subject | View Object

Following a 24 h incubation with LPS, a significant stimulation of STAT3 (Mann– Whitney U=0, Z=-2.882, P=0.004) and p65 NFkB phosphorylation was observed (Mann–Whitney U=1, Z=-2.722, P=0.006) PubMed:23178521

Appears in Networks:
Annotations
Cell Ontology (CL)
mononuclear cell

a(CHEBI:lipopolysaccharide) increases p(HGNC:IL1B) View Subject | View Object

Anatabine at 200 mg/ ml significantly lowered LPS induced IL-1b levels in whole blood (Mann–Whitney U=0.0, Z=-2.3, P=0.02) PubMed:23178521

Appears in Networks:

a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) View Subject | View Object

Our results showed that intraperitoneal injection of LPS (1 mg/kg) caused a significant elevation of plasma IL-1b (Mann–Whitney U=3, Z=-2.988, P=0.003), IL-6 (Mann–Whitney U=0, Z=-3.366, P=0.001) and TNFa (Mann– Whitney U=0, Z=-3.508, P<0.001) 4 h after the LPS challenge whereas in mice co-treated with an intraperitoneal injection of anatabine (2 mg/kg) and LPS, a significant reduction in plasma IL-1b (Mann–Whitney U=7, Z=-2.645, P=0.008) and TNFa (Mann–Whitney U=4, Z=-2.941, P=0.003) levels was observed (Fig. 6) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Plasma

a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) View Subject | View Object

An elevation of IL-6 (Mann–Whitney U=0, Z=-3.487, P<0.001), IL1b (Mann– Whitney U=0, Z=-3.24, P=0.001) and TNFa (Mann–Whitney U=0, Z=-3.361, P=0.001) was observed in the spleen of LPS challenged mice (Fig. 7) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Spleen

a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) View Subject | View Object

Similarly, IL-1b (Mann–Whitney U=0, Z=-3.098, P=0.002), IL-6 (Mann–Whitney U=0, Z=-3.363, P<0.001) and TNF-a levels (Mann–Whitney U=0, Z=-3.361, P=0.001) were elevated in the kidney following the LPS challenge (data not shown) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Kidney

a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) View Subject | View Object

Our results showed that intraperitoneal injection of LPS (1 mg/kg) caused a significant elevation of plasma IL-1b (Mann–Whitney U=3, Z=-2.988, P=0.003), IL-6 (Mann–Whitney U=0, Z=-3.366, P=0.001) and TNFa (Mann– Whitney U=0, Z=-3.508, P<0.001) 4 h after the LPS challenge whereas in mice co-treated with an intraperitoneal injection of anatabine (2 mg/kg) and LPS, a significant reduction in plasma IL-1b (Mann–Whitney U=7, Z=-2.645, P=0.008) and TNFa (Mann–Whitney U=4, Z=-2.941, P=0.003) levels was observed (Fig. 6) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Plasma

a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) View Subject | View Object

An elevation of IL-6 (Mann–Whitney U=0, Z=-3.487, P<0.001), IL1b (Mann– Whitney U=0, Z=-3.24, P=0.001) and TNFa (Mann–Whitney U=0, Z=-3.361, P=0.001) was observed in the spleen of LPS challenged mice (Fig. 7) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Spleen

a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) View Subject | View Object

Similarly, IL-1b (Mann–Whitney U=0, Z=-3.098, P=0.002), IL-6 (Mann–Whitney U=0, Z=-3.363, P<0.001) and TNF-a levels (Mann–Whitney U=0, Z=-3.361, P=0.001) were elevated in the kidney following the LPS challenge (data not shown) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Kidney

a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) View Subject | View Object

Our results showed that intraperitoneal injection of LPS (1 mg/kg) caused a significant elevation of plasma IL-1b (Mann–Whitney U=3, Z=-2.988, P=0.003), IL-6 (Mann–Whitney U=0, Z=-3.366, P=0.001) and TNFa (Mann– Whitney U=0, Z=-3.508, P<0.001) 4 h after the LPS challenge whereas in mice co-treated with an intraperitoneal injection of anatabine (2 mg/kg) and LPS, a significant reduction in plasma IL-1b (Mann–Whitney U=7, Z=-2.645, P=0.008) and TNFa (Mann–Whitney U=4, Z=-2.941, P=0.003) levels was observed (Fig. 6) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Plasma

a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) View Subject | View Object

An elevation of IL-6 (Mann–Whitney U=0, Z=-3.487, P<0.001), IL1b (Mann– Whitney U=0, Z=-3.24, P=0.001) and TNFa (Mann–Whitney U=0, Z=-3.361, P=0.001) was observed in the spleen of LPS challenged mice (Fig. 7) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Spleen

a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) View Subject | View Object

Similarly, IL-1b (Mann–Whitney U=0, Z=-3.098, P=0.002), IL-6 (Mann–Whitney U=0, Z=-3.363, P<0.001) and TNF-a levels (Mann–Whitney U=0, Z=-3.361, P=0.001) were elevated in the kidney following the LPS challenge (data not shown) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Kidney

a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(Ph)) View Subject | View Object

Western-blot experiments revealed that LPS significantly stimulated of STAT3 phosphorylation in the spleen (Mann–Whitney U=0, Z=-2.309, P=0.021) (Fig. 8) and kidney (Mann–Whitney U=0, Z=-2.882, P=0.004) (data not shown) whereas anatabine significantly inhibited STAT3 phosphorylation in the spleen (Mann–Whitney U=1, Z=-2.021, P=0.043) and kidney (Mann– Whitney U=5, Z=-2.082, P=0.037) (data not shown) PubMed:23178521

Appears in Networks:
Annotations
MeSH
Kidney
MeSH
Spleen

a(CHEBI:lipopolysaccharide) increases bp(GO:"macrophage activation") View Subject | View Object

Anatabine suppressed in a dose- dependent manner the increase of iNOS and COX2 in- duced by interferon-g (Fig.4),confirming in vitro its antiinflammatory properties. The effect seen with inter- feron-g was also seen when macrophages were stimulated with lipopolysaccharide (Supplemental Fig. 1). PubMed:22807490

Appears in Networks:

a(CHEBI:lipopolysaccharide) increases a(MESH:Cytokines) View Subject | View Object

Transfusion of RBCs after prolonged refrigerator storage is associated with haemolysis (Donadee et al, 2011; Hod et al, 2011) and enhances cytokine secretion in response to lipopolysaccharide (LPS) administration (Hod et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

a(CHEBI:lipopolysaccharide) negativeCorrelation r(MGI:Slc40a1) View Subject | View Object

We showed that simulation of macrophages with LPS resulted in significant reduction in ferroportin mRNA and protein expression and enhanced intracellular iron deposition throughout all time points tested (Fig. 5A–D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:lipopolysaccharide) negativeCorrelation p(MGI:Slc40a1) View Subject | View Object

We showed that simulation of macrophages with LPS resulted in significant reduction in ferroportin mRNA and protein expression and enhanced intracellular iron deposition throughout all time points tested (Fig. 5A–D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:lipopolysaccharide) negativeCorrelation p(MGI:Slc40a1) View Subject | View Object

This dramatically contrasts the iron phenotype that develops in response to LPS, hallmarked by high intracellular iron levels and low ferroportin expression (10, 20, 48). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Discussion

a(CHEBI:lipopolysaccharide) positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

We showed that simulation of macrophages with LPS resulted in significant reduction in ferroportin mRNA and protein expression and enhanced intracellular iron deposition throughout all time points tested (Fig. 5A–D). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Results

a(CHEBI:lipopolysaccharide) positiveCorrelation a(CHEBI:"iron(2+)") View Subject | View Object

This dramatically contrasts the iron phenotype that develops in response to LPS, hallmarked by high intracellular iron levels and low ferroportin expression (10, 20, 48). PubMed:29212341

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Text Location
Discussion

a(CHEBI:lipopolysaccharide) increases p(HGNC:HBB) View Subject | View Object

In animal experiments, the administration of lipopolysaccharide (LPS) to induce systemic inflammation leads to a significant increase in plasma concentration of cell-free hemoglobin as well [5–8]. PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

a(CHEBI:lipopolysaccharide) increases bp(GO:"cell death") View Subject | View Object

Due to these properties, LPS can easily be incorporated into the membrane of (red blood) cells, alter their membrane properties, and thus promote cell death [123, 124]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

a(CHEBI:lipopolysaccharide) increases bp(MESH:"Osmotic Fragility") View Subject | View Object

We found, moreover, a decreased osmotic resistance and membrane stiffness of washed red blood cells treated with LPS [80, 81]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.