Upload at 2018-04-03 15:16:13
Causal Biological Networks Database
The Fibrosis network depicts causal mechanisms that describe fibrosis and epithelial-to-mesenchymal cell transition (EMT) in lung tissue repair, including distinct characteristics of lung fibrosis such as TGFB1, collagen and MMPs. The network also contains signaling components of the Wnt, Hedgehog, and EGFR pathways that promote fibrosis and EMT.
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 61%
Selventa Protein Families Definitions v20150611 37%
ECM Degradation-2.0-Rn v2.0 33%
Fibrosis-2.0-Hs v2.0 28%
Fibrosis-2.0-Mm v2.0 27%
Growth Factor-2.0-Rn v2.0 27%
Hox-2.0-Rn v2.0 26%
Cell Interaction-2.0-Rn v2.0 24%
Wnt-2.0-Rn v2.0 24%
Wound Healing-2.0-Rn v2.0 23%

Sample Edges

bp(GOBP:"epithelial to mesenchymal transition") increases path(MESHD:Fibrosis)

A process by which epithelial cells lose cell-cell attachment, polarity and epithelial-specific markers, undergo cytoskeletal remodeling, and gain a mesenchymal phenotype, EMT plays a prominent role in fibrogenesis in adult tissues such as the kidney. This review summarizes the evidence supporting a central role for EMT in the pathogenesis of lung fibrosis PubMed:16738204

Sample Nodes

p(SFAM:"MAPK p38 Family")

In-Edges: 300 | Out-Edges: 234 | Explore Neighborhood | Download JSON


In-Edges: 43 | Out-Edges: 18 | Explore Neighborhood | Download JSON


In-Edges: 267 | Out-Edges: 239 | Explore Neighborhood | Download JSON


In-Edges: 23 | Out-Edges: 6 | Explore Neighborhood | Download JSON


In-Edges: 173 | Out-Edges: 60 | Explore Neighborhood | Download JSON


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