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a(MESH:ferrylhemoglobin)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
ferrylhemoglobin
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

bp(GO:"cellular respiration") negativeCorrelation a(MESH:ferrylhemoglobin) View Subject | View Object

Exposure to HbFe41 resulted in a drop in hyperpolarized cell percentage over untreated control, thus indicating a significant mitochondrial depolarization or compromised mitochondrial respiration. PubMed:26974230

Appears in Networks:
Annotations
MeSH
Mitochondria
Text Location
Results

bp(GO:"mitochondrial depolarization") positiveCorrelation a(MESH:ferrylhemoglobin) View Subject | View Object

Exposure to HbFe41 resulted in a drop in hyperpolarized cell percentage over untreated control, thus indicating a significant mitochondrial depolarization or compromised mitochondrial respiration. PubMed:26974230

Appears in Networks:
Annotations
MeSH
Mitochondria
Text Location
Results

bp(HM:"cytoskeletal reorganization") positiveCorrelation a(MESH:ferrylhemoglobin) View Subject | View Object

For example, HbFe41 (20 mM), but not HbFe31 or HbFe21, induced cytoskeletal reorganization, inflammation and disrupted barrier integrity in endothelial cells after 8 hours of incubation with the proteins. PubMed:26974230

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Discussion

complex(a(MESH:"Reactive Oxygen Species"), p(HGNC:HBB)) increases a(MESH:ferrylhemoglobin) View Subject | View Object

After hemolysis, sustained interaction between Hb and ROS can lead to ferrylhemoglobin (ferrylHb) formation, which is characterized by an increase in the Fe oxidative state to Fe+4 (Harel and Kanner, 1988; Patel et al., 1996). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

path(MESH:Inflammation) positiveCorrelation a(MESH:ferrylhemoglobin) View Subject | View Object

We recently found that, contrary to other forms of oxidized hemoglobin, ferrylhemoglobin acts as a potent pro-inflammatory agonist in endothelial cells, leading to the up-regulation of adhesion molecules that support the recruitment of macrophages into the vessel wall.36 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Discussion

path(MESH:Inflammation) positiveCorrelation a(MESH:ferrylhemoglobin) View Subject | View Object

For example, HbFe41 (20 mM), but not HbFe31 or HbFe21, induced cytoskeletal reorganization, inflammation and disrupted barrier integrity in endothelial cells after 8 hours of incubation with the proteins. PubMed:26974230

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Discussion

rxn(reactants(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"iron(2+)"), a(CHEBI:dioxygen)), products(a(MESH:ferrylhemoglobin))) hasProduct a(MESH:ferrylhemoglobin) View Subject | View Object

Appears in Networks:

Out-Edges 12

a(MESH:ferrylhemoglobin) positiveCorrelation path(MESH:Inflammation) View Subject | View Object

We recently found that, contrary to other forms of oxidized hemoglobin, ferrylhemoglobin acts as a potent pro-inflammatory agonist in endothelial cells, leading to the up-regulation of adhesion molecules that support the recruitment of macrophages into the vessel wall.36 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Discussion

a(MESH:ferrylhemoglobin) positiveCorrelation path(MESH:Inflammation) View Subject | View Object

For example, HbFe41 (20 mM), but not HbFe31 or HbFe21, induced cytoskeletal reorganization, inflammation and disrupted barrier integrity in endothelial cells after 8 hours of incubation with the proteins. PubMed:26974230

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Discussion

a(MESH:ferrylhemoglobin) increases a(MESH:"Cell Adhesion Molecules") View Subject | View Object

We recently found that, contrary to other forms of oxidized hemoglobin, ferrylhemoglobin acts as a potent pro-inflammatory agonist in endothelial cells, leading to the up-regulation of adhesion molecules that support the recruitment of macrophages into the vessel wall.36 PubMed:20378845

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Atherosclerosis
Text Location
Discussion

a(MESH:ferrylhemoglobin) increases bp(GO:"endothelial cell activation") View Subject | View Object

Similarly to heme, ferrylHb activates endothelial cells through NFκB activation (Silva et al., 2009). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

a(MESH:ferrylhemoglobin) causesNoChange a(MESH:Cytokines) View Subject | View Object

Moreover, ferrylHb is unable to induce cytokine secretion by endothelial cells (Silva et al., 2009), another difference to heme which induces IL-8 production (Natarajan et al., 2007). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

a(MESH:ferrylhemoglobin) increases p(HGNC:CXCL8) View Subject | View Object

Moreover, ferrylHb is unable to induce cytokine secretion by endothelial cells (Silva et al., 2009), another difference to heme which induces IL-8 production (Natarajan et al., 2007). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

a(MESH:ferrylhemoglobin) increases a(CHEBI:heme) View Subject | View Object

Like MetHb, ferrylHb is unstable and releases free heme to further increase oxLDL formation (Potor et al., 2013). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Cerebral Hemorrhage
Text Location
Review

a(MESH:ferrylhemoglobin) increases p(MGI:Hmox1) View Subject | View Object

Exposure to HbFe41 caused a significant up-regulation of HO-1 within 12 hours when compared with HbFe21 and HbFe31 (Figures 4A and 4B). PubMed:26974230

Appears in Networks:
Annotations
MeSH
Mitochondria
Text Location
Results

a(MESH:ferrylhemoglobin) increases p(MGI:Hmox1) View Subject | View Object

We found significant enrichment of HO-1 in mitochondrial fraction after exposure to HbFe31 and HbFe41 (Figure 4C). PubMed:26974230

Appears in Networks:
Annotations
MeSH
Mitochondria
Text Location
Results

a(MESH:ferrylhemoglobin) positiveCorrelation bp(GO:"mitochondrial depolarization") View Subject | View Object

Exposure to HbFe41 resulted in a drop in hyperpolarized cell percentage over untreated control, thus indicating a significant mitochondrial depolarization or compromised mitochondrial respiration. PubMed:26974230

Appears in Networks:
Annotations
MeSH
Mitochondria
Text Location
Results

a(MESH:ferrylhemoglobin) negativeCorrelation bp(GO:"cellular respiration") View Subject | View Object

Exposure to HbFe41 resulted in a drop in hyperpolarized cell percentage over untreated control, thus indicating a significant mitochondrial depolarization or compromised mitochondrial respiration. PubMed:26974230

Appears in Networks:
Annotations
MeSH
Mitochondria
Text Location
Results

a(MESH:ferrylhemoglobin) positiveCorrelation bp(HM:"cytoskeletal reorganization") View Subject | View Object

For example, HbFe41 (20 mM), but not HbFe31 or HbFe21, induced cytoskeletal reorganization, inflammation and disrupted barrier integrity in endothelial cells after 8 hours of incubation with the proteins. PubMed:26974230

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Mitochondria
Text Location
Discussion

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.