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p(HGNC:MAPK1)

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Entity

Name
MAPK1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 5

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

Identification of the Tau phosphorylation pattern that drives its aggregation v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 9

bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1)) View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1)) View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1)) View Subject | View Object

Abeta initiates intracellular signaling cascades via nAChRs (Fig. 3), including the MAPK kinase signaling pathway, resulting in cell death. In hippocampal slices, Abeta activates ERK-2 isoforms of the ERK MAPK. This is blocked by alpha7 antagonists, suggesting that Abeta evokes the cascade through alpha7 nAChRs (Dineley et al., 2001). PubMed:19293145

Appears in Networks:
Annotations
MeSH
Hippocampus

composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) hasComponent p(HGNC:MAPK1) View Subject | View Object

Appears in Networks:

act(p(HGNC:CDK5), ma(kin)) positiveCorrelation act(p(HGNC:MAPK1), ma(kin)) View Subject | View Object

Since Erk1/2 activity has been shown to induce cdk5 (Harada et al, 2001), miR-125b-induced Erk1/2 activation through DUSP6 downregulation might ultimately stimulate aberrant cdk5/p35 activation and, consequently, enhance pathological tau phosphorylation at multiple sites PubMed:25001178

Appears in Networks:

m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK1), ma(kin)) View Subject | View Object

In primary neurons, overexpression of miR-125b causes tau hyperphosphorylation and an upregulation of p35, cdk5, and p44/42-MAPK signaling. In parallel, the phosphatases DUSP6 and PPP1CA and the anti-apoptotic factor Bcl-W are downregulated as direct targets of miR-125b. Knockdown of these phosphatases induces tau hyperphosphorylation, and overexpression of PPP1CA and Bcl-W prevents miR-125b-induced tau phosphorylation, suggesting that they mediate the effects of miR-125b on tau. Conversely, suppression of miR-125b in neurons by tough decoys reduces tau phosphorylation and kinase expression/activity. Injecting miR-125b into the hippocampus of mice impairs associative learning and is accompanied by downregulation of Bcl-W, DUSP6, and PPP1CA, resulting in increased tau phosphorylation in vivo. Importantly, DUSP6 and PPP1CA are also reduced in AD brains. PubMed:25001178

Appears in Networks:

act(p(HGNC:DUSP6)) negativeCorrelation act(p(HGNC:MAPK1), ma(kin)) View Subject | View Object

Since Erk1/2 activity has been shown to induce cdk5 (Harada et al, 2001), miR-125b-induced Erk1/2 activation through DUSP6 downregulation might ultimately stimulate aberrant cdk5/p35 activation and, consequently, enhance pathological tau phosphorylation at multiple sites PubMed:25001178

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:MAPK1) View Subject | View Object

The highly vulnerable CA1 pyramidal neurons were characterized by age- and disease-unrelated increases in PRCKB levels and by age- and disease-related increases in MAPK1 levels. In contrast, low PRKCB levels were found in CA2 pyramidal neurons, and MAPK1 levels were elevated in controls and intermediate AD stages. Both PRKCB and MAPK1 were increased in the late AD stages. MAPK1 and PRKCB levels were low in the brainstem and cerebellum. PubMed:21910444

Appears in Networks:
Annotations
Uberon
pyramidal layer of CA1
MeSH
Alzheimer Disease

complex(p(HGNC:MAPK1), p(HGNC:MAPK14), p(HGNC:MAPK8)) hasComponent p(HGNC:MAPK1) View Subject | View Object

Appears in Networks:

Out-Edges 9

act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity") View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder") View Subject | View Object

Recent studies have supported a role for ERK and CREB activity in neural plasticity associated with nicotine addiction (71, 381, 484). It has also been proposed that the ERK and JAK-2/STAT-3 signaling pathways contribute to the toxic effects of nicotine in skin cells (42), and other pathways contribute to the effects of nicotine and other nicotinic ligands on inflammatory responses as described below. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

p(HGNC:MAPK1) hasVariant p(HGNC:MAPK1, pmod(Ph)) View Subject | View Object

Appears in Networks:

act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process") View Subject | View Object

Abeta initiates intracellular signaling cascades via nAChRs (Fig. 3), including the MAPK kinase signaling pathway, resulting in cell death. In hippocampal slices, Abeta activates ERK-2 isoforms of the ERK MAPK. This is blocked by alpha7 antagonists, suggesting that Abeta evokes the cascade through alpha7 nAChRs (Dineley et al., 2001). PubMed:19293145

Appears in Networks:
Annotations
MeSH
Hippocampus

act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) View Subject | View Object

When combined with ERK2 catalyzed phosphorylation, the turn-like disrupting G207V mutation in TauF8 hence leads to fast aggregation that already occurs during the phosphorylation reaction. PubMed:28784767

Appears in Networks:

act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) View Subject | View Object

When combined with ERK2 catalyzed phosphorylation, the turn-like disrupting G207V mutation in TauF8 hence leads to fast aggregation that already occurs during the phosphorylation reaction. PubMed:28784767

Appears in Networks:

act(p(HGNC:MAPK1), ma(kin)) negativeCorrelation act(p(HGNC:DUSP6)) View Subject | View Object

Since Erk1/2 activity has been shown to induce cdk5 (Harada et al, 2001), miR-125b-induced Erk1/2 activation through DUSP6 downregulation might ultimately stimulate aberrant cdk5/p35 activation and, consequently, enhance pathological tau phosphorylation at multiple sites PubMed:25001178

Appears in Networks:

act(p(HGNC:MAPK1), ma(kin)) positiveCorrelation act(p(HGNC:CDK5), ma(kin)) View Subject | View Object

Since Erk1/2 activity has been shown to induce cdk5 (Harada et al, 2001), miR-125b-induced Erk1/2 activation through DUSP6 downregulation might ultimately stimulate aberrant cdk5/p35 activation and, consequently, enhance pathological tau phosphorylation at multiple sites PubMed:25001178

Appears in Networks:

p(HGNC:MAPK1) increases a(MESH:Cytokines) View Subject | View Object

Furthermore, cytokine secretion depends on the coordinated iron in the porphyrin ring (Figueiredo et al, 2007), and nuclear factor-jB (NF-jB), MAPKs activation and ROS are essential for the increase in cytokine production induced by haem (Fernandez et al, 2010). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.