Upload at 2018-04-03 15:16:24
Causal Biological Networks Database
The Growth Factor network depicts the causal mechanisms of common extracellular growth factors involved in regulating lung cell proliferation, namely EGF, TGF-beta, VEGF, and FGF family members. The EGF family members EGF and TGF-alpha play critical roles in regulating the proliferation of airway epithelial cells through EGF receptor activation. FGF7 and FGF10, largely through activation of FGFR2 signaling, stimulate lung epithelial cell proliferation as well as regulate branching morphogenesis in the developing lung. VEGF, a key regulator of normal angiogenesis that is also involved in regulating proliferation of human fetal airway epithelial cells, was also included in the network. \nReviewed during Jamboree2014
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 70%
Mapk-2.0-Rn v2.0 45%
Mapk-2.0-Hs v2.0 39%
Selventa Protein Families Definitions v20150611 38%
Growth Factor-2.0-Hs v2.0 38%
Hox-2.0-Rn v2.0 37%
Growth Factor-2.0-Mm v2.0 35%
Mapk-2.0-Mm v2.0 32%
PGE2-2.0-Rn v2.0 29%
Osmotic Stress-2.0-Rn v2.0 29%

Sample Edges

Sample Nodes


In-Edges: 152 | Out-Edges: 75 | Explore Neighborhood | Download JSON


In-Edges: 51 | Out-Edges: 11 | Explore Neighborhood | Download JSON

p(SFAM:"MAPK p38 Family")

In-Edges: 300 | Out-Edges: 234 | Explore Neighborhood | Download JSON


In-Edges: 592 | Out-Edges: 336 | Explore Neighborhood | Download JSON


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