Provenance

Upload
charles.hoyt@scai.fraunhofer.de at 2018-04-03 15:16:24
Authors
Causal Biological Networks Database
Contact
CausalBiologicalNetworks.RD@pmi.com
Description
The Growth Factor network depicts the causal mechanisms of common extracellular growth factors involved in regulating lung cell proliferation, namely EGF, TGF-beta, VEGF, and FGF family members. The EGF family members EGF and TGF-alpha play critical roles in regulating the proliferation of airway epithelial cells through EGF receptor activation. FGF7 and FGF10, largely through activation of FGFR2 signaling, stimulate lung epithelial cell proliferation as well as regulate branching morphogenesis in the developing lung. VEGF, a key regulator of normal angiogenesis that is also involved in regulating proliferation of human fetal airway epithelial cells, was also included in the network. \nReviewed during Jamboree2014
License
Please cite: - www.causalbionet.com - https://bionet.sbvimprover.com as well as any relevant publications. The sbv IMPROVER project, the website and the Symposia are part of a collaborative project designed to enable scientists to learn about and contribute to the development of a new crowd sourcing method for verification of scientific data and results. The current challenges, website and biological network models were developed and are maintained as part of a collaboration among Selventa, OrangeBus and ADS. The project is led and funded by Philip Morris International. For more information on the focus of Philip Morris International’s research, please visit www.pmi.com.
Number Nodes
219
Number Edges
569
Number Components
30
Network Density
0.0119182
Average Degree
2.59817
Number Citations
278
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 70%
Mapk-2.0-Rn v2.0 45%
Mapk-2.0-Hs v2.0 39%
Selventa Protein Families Definitions v20150611 38%
Growth Factor-2.0-Hs v2.0 38%
Hox-2.0-Rn v2.0 37%
Growth Factor-2.0-Mm v2.0 35%
Mapk-2.0-Mm v2.0 32%
PGE2-2.0-Rn v2.0 29%
Osmotic Stress-2.0-Rn v2.0 29%

Sample Edges

Sample Nodes

p(HGNC:JUN)

In-Edges: 152 | Out-Edges: 75 | Explore Neighborhood | Download JSON

p(HGNC:ELK1)

In-Edges: 51 | Out-Edges: 11 | Explore Neighborhood | Download JSON

p(SFAM:"MAPK p38 Family")

In-Edges: 300 | Out-Edges: 234 | Explore Neighborhood | Download JSON

p(HGNC:MAPK1)

In-Edges: 592 | Out-Edges: 336 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.