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complex(GO:"NLRP3 inflammasome complex")

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Components

Entity

Name
NLRP3 inflammasome complex
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 4

Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2

Activation and regulation of the inflammasomes v1.0.0

The role of inflammasome in Alzheimer’s disease v1.0.3

Inflammasome Involvement in Alzheimer’s Disease v1.0.0

In-Edges 23

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

NLRP3 inflammasome activation results from TLR ligation and concomitant uptake of Ab in models of AD PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph

a(CHEBI:"(+)-artemisinin") decreases complex(GO:"NLRP3 inflammasome complex") View Subject | View Object

Using a similar mouse model, Shi et al. treated animals with the antimalarial drug artemisinin, showing that this treatment results in inhibition of NFkB and presumably the NLRP3 inflammasome (13) PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Nuclear factor Kappa beta subgraph

a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Using the herbizide, N,N0-dimethyl-4,40-bipyridinium dichloride (paraquat) as a mitochondrial toxin, which is known to induce oxidative stress, Chen et al. found increased levels of caspase-1 and IL-1b in brain of wild type and APP/PS1 transgenic mice (2), suggesting that those were due to NLRP3 inflammasome activation PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Caspase subgraph

a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Activation of the NLRP3 inflammasome by fibrillar Abeta has been described first by Halle et al. in 2008 PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph

a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

NLRP3 inflammasome activation results from TLR ligation and concomitant uptake of Ab in models of AD PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Toll like receptor subgraph

bp(GO:"innate immune response") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

One of the canonical pathways of this innate immune response evoked by Abeta is the activation of the NOD-like receptor (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome that became a focus of intense research PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Innate immune system subgraph

composite(a(CHEBI:"amyloid-beta"), p(HGNC:CD36)) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Soluble Abeta (sAbeta)-induces NLRP3 inflammasome activation, however it requires the presence of the surface receptor CD36 (12) PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph

composite(a(CHEBI:"amyloid-beta"), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

NLRP3 activation was characterized by ASC speck formation in an immune-activated microglial cell line and required a dual signal to become effective: the phagocytic uptake of Abeta and cathepsin B release after lysosomal disruption PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph

p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex") View Subject | View Object

The combined effect of the increased IDE production and phagocytic Abeta clearance reduced the cerebral Abeta load substantially, even at late life. Since immunohistochemistry found NLRP3 exclusively expressed in microglial cells, it has been concluded that the observed changes were entirely due to NLRP3 inflammasome modulation in these cells PubMed:28019679

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Insulin signal transduction

a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

A few molecules, such as amyloid-β, can induce both NLRP3 priming through TLR activation and NLRP3 inflammasome activation68. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Similarly, activation of the NLRP1B and NLRP3 inflammasomes depends on low K+ concentrations in intracellular compartments79, and a low K+ concentration promotes the assembly of the ASC speck6. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Intracellular Space
NeuroMMSigDB
Caspase subgraph

a(MESH:Interferons) decreases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

IFNs upregulate AIM2 expression but they downregulate IL-1β expression and inhibit the NLRP3 inflammasome. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Interferon signaling subgraph
NeuroMMSigDB
Interleukin signaling subgraph

bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Thus, it is not surprising that effector and memory CD4+ T cells have the capacity to inhibit the activation of the NLRP1 and NLRP3 inflammasomes in a contact-dependent manner, possibly via TNFR superfamily molecules such as CD40 ligand (CD40L)70. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

bp(GO:"response to endoplasmic reticulum stress") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

The authors proposed that another, not yet characterized, ER stress pathway activates the NLRP3 inflammasome90. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Extracellular Space
NeuroMMSigDB
Caspase subgraph

p(HGNC:DDIT3) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Another regulator of Ca2+, namely C/EPB-homologous protein (CHOP; also known as DDIT3), has been implicated in NLRP3 inflammasome activation89 PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
MeSH
Extracellular Space
NeuroMMSigDB
Caspase subgraph

a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Phagocytosis and subsequent lysosomal damage trigger by Aβ initiate the activation of the NLRP3 inflammasome in the microglia (Halle et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Endosomal lysosomal subgraph

a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

In vivo and cell studies demonstrate that fibrillar Aβ activates the NLRP3 inflammasome which is composed of the NLRP3 receptor, ASC and caspase-1, to produce IL-1β in microglia (Halle et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell
Confidence
Medium
NeuroMMSigDB
Amyloidogenic subgraph

bp(GO:phagocytosis) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Phagocytosis and subsequent lysosomal damage trigger by Aβ initiate the activation of the NLRP3 inflammasome in the microglia (Halle et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph

complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

As for the NLRP1 and NLRP3 inflammasomes, the oligomerzied NLRs recruit and interact with the adaptor protein ASC, which in turn recruits the effector protein procaspase-1 that is central to the activation of inflammasomes (Huang et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

path(MESH:"Alzheimer Disease") association complex(GO:"NLRP3 inflammasome complex") View Subject | View Object

In support, a recent study in APP/PS1 mice confirms that the NLRP3 inflammasome contributes to the AD pathology (Heneka et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium

a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

Of these, the NLRP3 inflammasome can be acti- vated via bacterial RNA species [3]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) hasComponent complex(GO:"NLRP3 inflammasome complex") View Subject | View Object

Appears in Networks:

p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) View Subject | View Object

P2X7 expressed by microglial cells will also activate the NLP3 inflammasome [30, 32] and the expression of P2X7 is likely to be increased in AD brains [35]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

Out-Edges 17

act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) View Subject | View Object

Activation of NLRP3 leads to the generation of interleukin-1b (IL-1b) and interleukin 18 (IL-18), which are being cleaved by caspase-1 from their inactive precursors and subsequently PubMed:28019679

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18) View Subject | View Object

Activation of NLRP3 leads to the generation of interleukin-1b (IL-1b) and interleukin 18 (IL-18), which are being cleaved by caspase-1 from their inactive precursors and subsequently PubMed:28019679

Appears in Networks:
Annotations
Confidence
Medium
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) View Subject | View Object

Using the herbizide, N,N0-dimethyl-4,40-bipyridinium dichloride (paraquat) as a mitochondrial toxin, which is known to induce oxidative stress, Chen et al. found increased levels of caspase-1 and IL-1b in brain of wild type and APP/PS1 transgenic mice (2), suggesting that those were due to NLRP3 inflammasome activation PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"NLRP3 inflammasome complex") increases act(p(HGNC:CASP1)) View Subject | View Object

NLRP3 inflammasome formation and subsequent activation of caspase-1 cleavage capacity was instrumental for Abeta-induced nitric oxide production and TNF-a release PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph

act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1) View Subject | View Object

Using the herbizide, N,N0-dimethyl-4,40-bipyridinium dichloride (paraquat) as a mitochondrial toxin, which is known to induce oxidative stress, Chen et al. found increased levels of caspase-1 and IL-1b in brain of wild type and APP/PS1 transgenic mice (2), suggesting that those were due to NLRP3 inflammasome activation PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Caspase subgraph

complex(GO:"NLRP3 inflammasome complex") increases a(CHEBI:"nitric oxide") View Subject | View Object

NLRP3 inflammasome formation and subsequent activation of caspase-1 cleavage capacity was instrumental for Abeta-induced nitric oxide production and TNF-a release PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Nitric oxide subgraph

complex(GO:"NLRP3 inflammasome complex") increases sec(p(HGNC:TNF)) View Subject | View Object

NLRP3 inflammasome formation and subsequent activation of caspase-1 cleavage capacity was instrumental for Abeta-induced nitric oxide production and TNF-a release PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Amyloidogenic subgraph
NeuroMMSigDB
Tumor necrosis factor subgraph

act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory") View Subject | View Object

This finding was associated with spatial memory dysfunction and an increase in Abeta plaque deposition PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Amyloidogenic subgraph

act(complex(GO:"NLRP3 inflammasome complex")) increases a(CHEBI:"amyloid-beta") View Subject | View Object

This finding was associated with spatial memory dysfunction and an increase in Abeta plaque deposition PubMed:28019679

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
NeuroMMSigDB
Amyloidogenic subgraph

complex(GO:"NLRP3 inflammasome complex") hasComponent p(HGNC:PYCARD) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) View Subject | View Object

In the CNS, the production of IL-1β by inflammasomes, specifically NLRP1, NLRP2, NLRP3 and NLRC4, is well-characterized as compared to other interleukins (Minkiewicz et al., 2013; Trendelenburg, 2008) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Central Nervous System
NeuroMMSigDB
Interleukin signaling subgraph

complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) View Subject | View Object

In vivo and cell studies demonstrate that fibrillar Aβ activates the NLRP3 inflammasome which is composed of the NLRP3 receptor, ASC and caspase-1, to produce IL-1β in microglia (Halle et al., 2008) PubMed:24561250

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell
Confidence
Medium
NeuroMMSigDB
Amyloidogenic subgraph

complex(GO:"NLRP3 inflammasome complex") hasComponent p(HGNC:NLRP3) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP3 inflammasome complex") hasComponent p(HGNC:CASP1) View Subject | View Object

Appears in Networks:

complex(GO:"NLRP3 inflammasome complex") association path(MESH:"Alzheimer Disease") View Subject | View Object

In support, a recent study in APP/PS1 mice confirms that the NLRP3 inflammasome contributes to the AD pathology (Heneka et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
Medium

complex(GO:"NLRP3 inflammasome complex") increases path(MESH:"Plaque, Amyloid") View Subject | View Object

Similarly, inhibiting the NLRP3 inflammasome reduces the neuritic plaque burden in an AD transgenic mouse model (Shi et al., 2013) PubMed:24561250

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease
NeuroMMSigDB
Amyloidogenic subgraph

complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1) View Subject | View Object

The NLRP3 inflammasome has a role in AD by increas- ing caspase-1 expression levels in AD brains [13, 23]. PubMed:27314526

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Alzheimer Disease
NeuroMMSigDB
Caspase subgraph

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.