Insulin signal transduction

Name: Insulin signal transduction
Namespace Keyword: Subgraph
Namespace: NeuroMMSigDB
Namespace Version: 1.0.3
Namespace URL: https://arty.scai.fraunhofer.de/artifactory/bel/annotation/neurommsig/neurommsig-1.0.3.belanno

Sample Annotated Edges 2

p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

The combined effect of the increased IDE production and phagocytic Abeta clearance reduced the cerebral Abeta load substantially, even at late life. Since immunohistochemistry found NLRP3 exclusively expressed in microglial cells, it has been concluded that the observed changes were entirely due to NLRP3 inflammasome modulation in these cells PubMed:28019679

Appears in Networks:

Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2

Annotations

Confidence: Medium
MeSH: Neurons
NeuroMMSigDB: Amyloidogenic subgraph
NeuroMMSigDB: Insulin signal transduction

p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex") View Subject | View Object

The combined effect of the increased IDE production and phagocytic Abeta clearance reduced the cerebral Abeta load substantially, even at late life. Since immunohistochemistry found NLRP3 exclusively expressed in microglial cells, it has been concluded that the observed changes were entirely due to NLRP3 inflammasome modulation in these cells PubMed:28019679

Appears in Networks:

Inflammasome activation and innate immunity in Alzheimer’s disease v1.0.2

Annotations

Confidence: Medium
MeSH: Neurons
NeuroMMSigDB: Amyloidogenic subgraph
NeuroMMSigDB: Insulin signal transduction

Showing 2 of 2 edges

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.