composite(a(CHEBI:"amyloid-beta"), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex"))

PubMed:28019679

NLRP3 activation was characterized by ASC speck formation in an immune-activated microglial cell line and required a dual signal to become effective: the phagocytic uptake of Abeta and cathepsin B release after lysosomal disruption

Confidence

High

NeuroMMSigDB

Amyloidogenic subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.